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Eva Ales González de la Higuera

Profesora Titular de Universidad
eales@us.es
Área de conocimiento: Fisiología
Departamento: Fisiología Médica y Biofísica
Grupo: BIOFISICA CELULAR - BIO-236 (Universidad de Sevilla)
Prog. doctorado: BIOLOGÍA MOLECULAR, BIOMEDICINA E INVESTIGACIÓN CLÍNICA

Investiga en

Tipo Año Título Fuente
Artículo2023 Ketotifen is a microglial stabilizer by inhibiting secretory vesicle acidification LIFE SCIENCES
Letter2023 Melatonin reduces exo-endocytosis in mast cells, making it a useful therapeutic tool in inflammatory diseases. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
Artículo2021 Mast Cell Changes the Phenotype of Microglia via Histamine and ATP CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Artículo2021 PDA-based glyconanomicelles for hepatocellular carcinoma cells active targeting via mannose and asialoglycoprotein receptors ACS Applied Bio Materials
Artículo2021 The human-specific duplicated α7 gene inhibits the ancestral α7, negatively regulating nicotinic acetylcholine receptor-mediated transmitter release JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2019 Proteoglycans involved in bidirectional communication between mast cells and hippocampal neurons JOURNAL OF NEUROINFLAMMATION
Artículo2016 Emerging roles of granule recycling in mast cell plasticity and homeostasis CRITICAL REVIEWS IN IMMUNOLOGY
Artículo2016 Intestinal and peritoneal mast cells differ in kinetics of quantal release BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Artículo2016 Transient fusion ensures granule replenishment to enable repeated release after IgE-mediated mast cell degranulation JOURNAL OF CELL SCIENCE
Artículo2015 Identification of a new exo-endocytic mechanism triggered by corticotropin-releasing hormone in mast cells JOURNAL OF IMMUNOLOGY
Artículo2014 A new role for myosin II in vesicle fission PLOS ONE
Ponencia2014 EXO-ENDOCYTOCYS IN RESPONSE TO STRESS HORMONAL STIMULATION IN PERITONEAL MAST CELLS. ACTA PHYSIOLOGICA
Ponencia2014 LOSS OF MYOSIN II FUNCTION REDUCES THE EFFICIENCY OF MEMBRANE SCISSION BY MAKING VESICLE CLOSURE INCOMPLETE ACTA PHYSIOLOGICA
Artículo2013 Mechanisms of Granule Membrane Recapture following Exocytosis in Intact Mast Cells JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2010 Dynamics and regulation of endocytotic fission pores: role of calcium and dynamin TRAFFIC
Artículo2010 Push-and-pull regulation of the fusion pore by synaptotagmin-7 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo2008 Myosin II contributes to fusion pore expansion during exocytosis JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2006 A rapid exocytosis mode in chromaffin cells with a neuronal phenotype JOURNAL OF NEUROCHEMISTRY
Artículo2006 Blockade of Ca2+-activated K+ channels by galantamine can also contribute to the potentiation of catecholamine secretion from chromaffin cells EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo2005 Depolarization evokes different patterns of calcium signals and exocytosis in bovine and mouse chromaffin cells: the role of mitochondria EUROPEAN JOURNAL OF NEUROSCIENCE
Artículo2004 A choline-evoked [Ca2+](C) signal causes catecholamine release and hyperpolarization of chromaffin cells FASEB JOURNAL
Artículo2004 Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors NEUROPHARMACOLOGY
Ponencia2003 Galantamine for Alzheimer's disease: A novel antiapoptotic mechanism linked to overexpression of Bcl-2 and alpha 7 receptors NEW TRENDS IN ALZHEIMER AND PARKINSON RELATED DISORDERS
Artículo2002 Different cellular distribution of calbindin D28k - Implications for the cytosolic Ca2+ and exocytotic signals in single bovine and mouse chromaffin cells ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Artículo2002 ERG K+ channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death? FASEB JOURNAL
Artículo2002 Modulatory mechanism of the endogenous peptide catestatin on neuronal nicotinic acetylcholine receptors and exocytosis JOURNAL OF NEUROSCIENCE
Artículo2001 Exocytosis of catecholamine (CA)-containing and CA-free granules in chromaffin cells JOURNAL OF BIOLOGICAL CHEMISTRY
Ponencia2001 Nicotine protects against ionophore-induced cytotoxicity in bovine chromaffin cells JOURNAL OF NEUROCHEMISTRY
Artículo2000 The sea anemone toxin Bc2 induces continuous or transient exocytosis, in the presence of sustained levels of high cytosolic Ca2+ in chromaffin cells JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1999 High calcium concentrations shift the mode of exocytosis to the kiss-and-run mechanism NATURE CELL BIOLOGY
Resumen congreso1999 Single granule secretion during action potentials in chromaffin cells BIOPHYSICAL JOURNAL
Resumen congreso1999 Total and fast release of catecholamine by rapid exo-endocytosis of single chromaffin granules BIOPHYSICAL JOURNAL
Resumen congreso1998 Dynamics of exocytosis of rat chromaffin granules JOURNAL OF PHYSIOLOGY-LONDON
Resumen congreso1998 Properties of amperometric spikes studied by patch amperometry Monte Carlo simulation in rat chromaffin cells JOURNAL OF PHYSIOLOGY-LONDON
Revisión1998 Release of neurotransmitters: A process of membrane fusion occurring in fractions of milliseconds REVISTA DE NEUROLOGIA
Artículo1997 On line quantification of mast cell degranulation with electrophysiological techniques INFLAMMATION RESEARCH
Resumen congreso1997 Plasma membrane dynamics in rat peritoneal mast cells studied by patch amperometry. BIOPHYSICAL JOURNAL
Resumen congreso1997 Plasma membrane dynamics studied by patch amperometry JOURNAL OF NEUROCHEMISTRY
Ponencia1997 Regulation of the exocytotic fusion pore by cytosolic calcium and conditions affecting the dissociation of secretory products from the granule matrix BIOPHYSICAL JOURNAL

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2009 30/12/2011 Responsable Regulación de la liberación de neurotransmisores: implicación de canales de calcio y neurotrofinas (PI081246) Ministerio de Ciencia e Innovación (Nacional)
01/01/2012 31/07/2015 Responsable Regulación molecular del poro de fusión: implicaciones en la liberación de mediadores de la inflamación (PI11/00257) Ministerio de Ciencia e Innovación (Instituto de Carlos III) (Nacional)
01/01/2018 30/09/2021 Responsable Papel del Mastocito en la Activación Microglial y Funcíón Sináptica Neuronal. Potencial Efecto Terapéutico de la Estabilización del Mastocito en la Enfermedad de Alzheimer. (BFU2017-85832-R) Ministerio de Economía y Competitividad (Nacional)
23/12/2005 23/12/2008 Responsable Comunicación neuronal mediante señales eléctricas y químicas (PI050675) Ministerio de Sanidad y Consumo (Instituto de Salud Carlos III) (Nacional)
03/02/2010 03/02/2013 Investigador/a Medida de Ca y Liberación de Neurotransmisores Mediante el Uso de Nanopartículas Fluorescentes (P09-CVI-4862) Junta de Andalucía (Consejería de Innovación, Ciencia y Empresas) (Autonómico)
13/04/2007 31/10/2010 Investigador/a Visualización en tiempo real de la transmisión sináptica (P06-CVI-02392) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
El investigador no tiene ningún resultado de investigación asociado