Ver Investigador - - Prisma - Unidad de Bibliometría

Lucía Tabares Domínguez

Catedrática de Universidad
Área de conocimiento: Fisiología
Departamento: Fisiología Médica y Biofísica
Prog. doctorado: Prog.Doct.en Biología Molecular, Biomedicina e Investigac.Clínica (RD.2011)
Tipo Año Título Fuente
Artículo2023 A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses NEURON
Artículo2023 Nifedipine ameliorates cellular differentiation defects of smn-deficient motor neurons and enhances neuromuscular transmission in SMA mice INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Editorial2022 Editorial: Molecular nanomachines of the presynaptic terminal, volume II Frontiers in Synaptic Neuroscience
Artículo2022 Functional regeneration of the murine neuromuscular synapse relies on long-lasting morphological adaptations BMC BIOLOGY
Artículo2022 Presynaptic mitochondria communicate with release sites for spatio-temporal regulation of exocytosis at the motor nerve terminal Frontiers in Synaptic Neuroscience
Artículo2022 SMN Is Physiologically Downregulated at Wild-Type Motor Nerve Terminals but Aggregates Together with Neurofilaments in SMA Mouse Models BIOMOLECULES
Artículo2021 Calcium is reduced in presynaptic mitochondria of motor nerve terminals during neurotransmission in SMA mice. HUMAN MOLECULAR GENETICS
Artículo2020 R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy iScience
Artículo2020 The mouse levator auris longus muscle: an amenable model system to study the role of postsynaptic proteins to the maintenance and regeneration of the neuromuscular synapse FRONTIERS IN CELLULAR NEUROSCIENCE
Artículo2019 BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo2018 HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System MOLECULAR NEUROBIOLOGY
Revisión2018 Maturation and heterogeneity of vertebrate motor synapses Current Opinion in Physiology
Artículo2017 Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction SYNAPSE
Artículo2017 CSP alpha, a Molecular Co-chaperone Essential for Short and Long-Term Synaptic Maintenance FRONTIERS IN NEUROSCIENCE
Artículo2017 Smn-deficiency increases the intrinsic excitability of motoneurons FRONTIERS IN CELLULAR NEUROSCIENCE
Editorial2016 Editorial: Molecular nanomachines of the presynaptic terminal Frontiers in Synaptic Neuroscience
Artículo2016 Synaptotagmin-2, and -1, linked to neurotransmission impairment and vulnerability in Spinal Muscular Atrophy HUMAN MOLECULAR GENETICS
Artículo2016 The Active and Periactive Zone Organization and the Functional Properties of Small and Large Synapses Frontiers in Synaptic Neuroscience
Artículo2015 Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions JOURNAL OF NEUROPHYSIOLOGY
Artículo2015 The HERC1 E3 Ubiquitin Ligase is essential for normal development and for neurotransmission at the mouse neuromuscular junction CELLULAR AND MOLECULAR LIFE SCIENCES
Artículo2014 alpha-Synuclein A30P decreases neurodegeneration and increases synaptic vesicle release probability in CSP alpha-null mice NEUROPHARMACOLOGY
Artículo2014 Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1 alpha NATURE COMMUNICATIONS
Artículo2014 Neurotransmitter release in motor nerve terminals of a mouse model of mild spinal muscular atrophy JOURNAL OF ANATOMY
Artículo2013 Fast motor axon loss in SMARD1 does not correspond to morphological and functional alterations of the NMJ NEUROBIOLOGY OF DISEASE
Artículo2013 Notch signaling pathway is activated in motoneurons of spinal muscular atrophy INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2013 Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality HUMAN MOLECULAR GENETICS
Revisión2013 Structural and functional maturation of active zones in large synapses MOLECULAR NEUROBIOLOGY
Artículo2012 Atrofia Muscular Espinal Fisiología
Artículo2012 Synaptic defects in spinal muscular atrophy animal models DEVELOPMENTAL NEUROBIOLOGY
Artículo2012 The functional landscape of a presynaptic nerve terminal CELL CALCIUM
Artículo2011 Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse JOURNAL OF NEUROSCIENCE
Artículo2011 Developing standard procedures for pre-clinical efficacy studies in mouse models of spinal muscular atrophy. Report of the expert workshop "Pre-clinical testing for SMA", Zürich, March 29-30th 2010 NEUROMUSCULAR DISORDERS
Artículo2011 SMN requirement for synaptic vesicle, active zone and microtubule postnatal organization in motor nerve terminals PLOS ONE
Artículo2010 Altered Intracellular Ca2+ Homeostasis in Nerve Terminals of Severe Spinal Muscular Atrophy Mice JOURNAL OF NEUROSCIENCE
Artículo2010 Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy HUMAN MOLECULAR GENETICS
Editorial2010 Multiple Functions of the Vesicular Proton Pump in Nerve Terminals NEURON
Artículo2009 Preferred Sites of Exocytosis and Endocytosis Colocalize during High- But Not Lower-Frequency Stimulation in Mouse Motor Nerve Terminals JOURNAL OF NEUROSCIENCE
Artículo2009 The spatial pattern of exocytosis and post-exocytic mobility of synaptopHluorin in mouse motor nerve terminals JOURNAL OF PHYSIOLOGY-LONDON
Artículo2008 Cysteine string protein- is essential for the high calcium sensitivity of exocytosis in a vertebrate synapse EUROPEAN JOURNAL OF NEUROSCIENCE
Artículo2007 Monitoring synaptic function at the neuromuscular junction of a mouse expressing synaptopHluorin JOURNAL OF NEUROSCIENCE
Artículo2007 Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration NEUROBIOLOGY OF DISEASE
Artículo2006 Adult stem cell therapy: dream or reality? Transplant Immunology
Artículo2006 CSP alpha-deficiency causes massive and rapid photoreceptor degeneration PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo2005 Patch amperometry: high-resolution measurements of single-vesicle fusion and release NATURE METHODS
Artículo2005 Treatment with trkC agonist antibodies delays disease progression in neuromuscular degeneration (nmd) mice HUMAN MOLECULAR GENETICS
Resumen congreso2004 Neuromuscular functional study of a mouse model of spinal muscular atrophy. BIOPHYSICAL JOURNAL
Resumen congreso2004 The kinetics of exocytosis in mast cells from an heparin knock-out mice BIOPHYSICAL JOURNAL
Artículo2004 The synaptic vesicle protein CSP alpha prevents presynaptic degeneration NEURON
Artículo2003 Relationship between fusion pore opening and release during mast cell exocytosis studied with patch amperometry BIOCHEMICAL SOCIETY TRANSACTIONS
Resumen congreso2002 Action potentials and quantal release in chromaffin cells BIOPHYSICAL JOURNAL
Resumen congreso2002 Cytosolic and granular catecholamine concentrations in chromaffin cells measured by patch electrochemistry. BIOPHYSICAL JOURNAL
Artículo2001 Dopamine induces intracellular Ca2+ signals mediated by alpha(1B)-adrenoceptors in rat pineal cells EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo2001 Estrogen modulates alpha(1)/beta-adrenoceptor-induced signaling and melatonin production in female rat pinealocytes NEUROENDOCRINOLOGY
Artículo2001 Exocytosis of catecholamine (CA)-containing and CA-free granules in chromaffin cells JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1999 High calcium concentrations shift the mode of exocytosis to the kiss-and-run mechanism NATURE CELL BIOLOGY
Resumen congreso1999 Single granule secretion during action potentials in chromaffin cells BIOPHYSICAL JOURNAL
Resumen congreso1999 Total and fast release of catecholamine by rapid exo-endocytosis of single chromaffin granules BIOPHYSICAL JOURNAL
Resumen congreso1998 Dynamics of exocytosis of rat chromaffin granules JOURNAL OF PHYSIOLOGY-LONDON
Resumen congreso1998 Oestrogen modulation of adrenergic transmission. A model for cross-talk between neurotransmitter and hormone-activated receptors JOURNAL OF PHYSIOLOGY-LONDON
Resumen congreso1998 Properties of amperometric spikes studied by patch amperometry Monte Carlo simulation in rat chromaffin cells JOURNAL OF PHYSIOLOGY-LONDON
Ponencia1997 Calcium signals mediated by noradrenergic and muscarinic receptor agonists in rat pineal cells PINEAL UPDATE
Resumen congreso1997 Dopamine receptor-mediated calcium release in rat pineal cells BIOPHYSICAL JOURNAL
Ponencia1997 Interactions between environmental and hormonal oscillations induce plastic changes in a simple neuroendocrine transducer Lecture Notes in Computer Science
Resumen congreso1997 Plasma membrane dynamics in rat peritoneal mast cells studied by patch amperometry. BIOPHYSICAL JOURNAL
Resumen congreso1997 Plasma membrane dynamics studied by patch amperometry JOURNAL OF NEUROCHEMISTRY
Artículo1996 Intracellular Calcium Release Mediated by Noradrenaline and Acetylcholine in Mammalian Pineal Cells JOURNAL OF PINEAL RESEARCH
Resumen congreso1990 Calcium-channel selectivity in squid neurons BIOPHYSICAL JOURNAL
Artículo1989 Properties of Calcium and Potassium Currents of Clonal Adrenocortical Cells JOURNAL OF GENERAL PHYSIOLOGY
Artículo1986 Calcium action potentials in cultured adrenocortical cells PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Artículo1986 Effects of membrane depolarization and divalent-cations on anaphylactic histamine secretion CELL CALCIUM
Capítulo1986 Potassium channels in adrenocortical and parathyroid cells Biophysics of the pancreatic β-cell
Artículo1984 Single channel currents in adrenocortical cells Revista Española de Fisiología

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/06/2020 28/02/2024 Responsable Homeostasis de Calcio Citosólico y Mitocondrial en Motoneuronas Smn-Deficientes. Estudio del Papel Neuroprotector de Moduladores de los Canales de K Dependientes de Calcio (PID2019-110272RB-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
01/01/2020 31/12/2022 Responsable Spinal muscular atrophy: Mechanisms implicated in the perturbation of the calcium homeostasis and essay of a new therapeutic molecular target (SMA EUROPE) SMA Europe (Europeo)
30/12/2016 29/12/2019 Responsable Regulación de la Expresión de Sv2b, Sinaptotagmina 1 y 2, y su Alteración en la Atrofia Muscular Espinal (BFU2016-78934-P) Ministerio de Economía y Competitividad (Nacional)
01/01/2014 30/09/2017 Responsable Variabilidad Funcional de los Terminales Nerviosos Motores y Vulnerabilidad Sináptica en Ame (BFU2013-43763-P) Ministerio de Economía y Competitividad (Nacional)
01/01/2011 30/11/2014 Responsable Papel del Citoesqueleto y de la Mitocondria en la Patogenia de la Atrofia Muscular Espinal (BFU2010-21648) Ministerio de Ciencia e Innovación (Nacional)
03/02/2010 03/02/2013 Investigador/a Medida de Ca y Liberación de Neurotransmisores Mediante el Uso de Nanopartículas Fluorescentes (P09-CVI-4862) Junta de Andalucía (Consejería de Innovación, Ciencia y Empresas) (Autonómico)
01/01/2010 31/12/2012 Responsable NMJ Presynaptic Function in a Mouse Transgenic with SynaptopHluorin (NMJ) MUSCULAR DYSTROPHY ASSOCIATION (UNIVERSIDAD DE COLORADO) (Internacional)
01/12/2007 30/11/2010 Responsable Estudio de la fisiología sináptica en tiempo real: regulación funcional de las zonas activas y modos de endocitosis (BFU2007-61771) Ministerio de Educación y Ciencia (Nacional)
13/04/2007 31/10/2010 Investigador/a Visualización en tiempo real de la transmisión sináptica (P06-CVI-02392) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
02/02/2007 31/12/2010 Responsable Mecanisme patogènics en el ratolí amb degeneració neuromuscular (NMD): un model per a I'Smard 1 humana (SUB07-015) La Fundació La Marató de TV3 (Autonómico)
01/01/2007 31/12/2010 Responsable Hot Spots of secretion and exocytosis of empty vesicles at the neuromuscular junction (MDA) MUSCULAR DYSTROPHY ASSOCIATION (UNIVERSIDAD DE COLORADO) (Internacional)
13/12/2004 13/12/2007 Responsable Estudio funcional en un modelo murino de atrofia muscular espinal del papel fisiológico de la proteína de supervivencia neuronal (SNM) en la unión neuromuscular (BFU2004-00350) Ministerio de Ciencia y Tecnología (Nacional)
01/06/2002 01/06/2006 Investigador/a Visualization of molecular events involved in endocytosis at the synapse (RGP 0045/2002-C) HFSPO-Bureaux Europe (Europeo)
28/12/2001 27/06/2005 Investigador/a Fisiología celular y molecular del reciclado de vesículas sinápticas y su participación en los fenómenos de plasticidad del sistema nervioso (BFI2001-3199) Ministerio de Ciencia y Tecnología (Nacional)
20/08/2001 31/12/2003 Investigador/a Genética funcional del ciclo de las vesículas sinápticas: implicaciones en la fisiopatología neuronal del Síndrome de Down (FIS-01/1098) Ministerio de Sanidad y Consumo (Instituto de Salud Carlos III) (Nacional)


Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/03/2007 01/03/2010 Responsable Defining targets for therapeutics in espinal muscular atrophy 'Proyecto Gename' (SI-044/07) Genoma España (Desconocido)
01/01/2003 01/01/2004 Responsable Trabajo de carácter científico (SI-002/03) Rinat Neuroscience Corporation (Desconocido)


Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2020 31/12/2020 Responsable Ayudas para el uso de los Servicios Generales de Investigación (PPI555/2020) Universidad de Sevilla (Local)
01/11/2014 31/08/2018 Responsable Bases Moleculares de las alteraciones sinápticas y Electrofisiológicas en la atrofia muscular espinal (SBFTPGB/002/2014) Fundación Tatiana Pérez de Guzmán el Bueno (Nacional)
01/03/2010 30/06/2010 Responsable Estancias de movilidad de profesores e investigadores extranjeros en centros españoles (SAB2009-0022) Ministerio de Educación y Ciencia (Nacional)
08/02/2005 - Responsable International Workshop in Pathophysiology (PP2004/01-11) Universidad de Sevilla (Local)
24/05/2004 24/05/2005 Investigador/a XXXIII Congress of the Spanich Physiological Society of Physiological Sciences. International joint meeting with the Physiological society and the Dutch Society of Physiology (BFI2002-12571-E) Ministerio de Educación y Ciencia (Nacional)


Nº Solicitud Fecha Solicitud Fecha Concesión Nombre
US2006016046W 26/04/2005 - Methods for treating lower motor neuron diseases and composotions containing the same