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Ver Investigador - - Prisma - Unidad de Bibliometría

Jesús de La Cruz Díaz

Catedrático de Universidad
jdlcd@us.es
Área de conocimiento: Genética
Departamento: Genética
Grupo: EXPRESION GENICA EN EUCARIONTES - BIO-271 (Universidad de Sevilla)
Centro mixto: Instituto de Biomedicina de Sevilla (IBIS)
Prog. doctorado: BIOLOGÍA INTEGRADA, BIOLOGÍA MOLECULAR, BIOMEDICINA E INVESTIGACIÓN CLÍNICA

Investiga en

Palabras clave
Líneas de investigación
Resumen
Tipo Año Título Fuente
Artículo2024 The Beak of Eukaryotic Ribosomes: Life, Work and Miracles BIOMOLECULES
Artículo2023 The Role of Ribosomal Proteins eL15 and eL36 in the Early Steps of Yeast 60S Ribosomal Subunit Assembly JOURNAL OF MOLECULAR BIOLOGY
Artículo2023 The Terminal Extensions of Dbp7 Influence Growth and 60S Ribosomal Subunit Biogenesis in Saccharomyces cerevisiae . INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2022 Broad transcriptomic impact of Sorafenib and its relation to the antitumoral properties in liver cancer cells CANCERS
Artículo2022 Ribosomal protein eL39 is important for maturation of the nascent polypeptide exit tunnel and proper protein folding during translation NUCLEIC ACIDS RESEARCH
Artículo2022 The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation. RNA BIOLOGY
Artículo2021 A functional connection between translation elongation and protein folding at the ribosome exit tunnel in Saccharomyces cerevisiae NUCLEIC ACIDS RESEARCH
Artículo2021 Association of snR190 snoRNA chaperone with early pre-60S particles is regulated by the RNA helicase Dbp7 in yeast NATURE COMMUNICATIONS
Revisión2021 Ubiquitin and ubiquitin-like proteins and domains in ribosome production and function: chance or necessity? INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2020 Molecular Pathways Leading to Induction of Cell Death and Anti-Proliferative Properties by Tacrolimus and mTOR Inhibitors in Liver Cancer Cells CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Artículo2020 Overexpression of budding yeast protein phosphatase Ppz1 impairs translation BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Artículo2020 Prefoldin-like Bud27 influences the transcription of ribosomal components and ribosome biogenesis in Saccharomyces cerevisiae RNA-A PUBLICATION OF THE RNA SOCIETY
Artículo2020 Role of the 40S beak ribosomal protein eS12 in ribosome biogenesis and function in Saccharomyces cerevisiae RNA BIOLOGY
Artículo2020 The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes NUCLEIC ACIDS RESEARCH
Artículo2020 Ubiquitin release from eL40 is required for cytoplasmic maturation and function of 60S ribosomal subunits in Saccharomyces cerevisiae FEBS JOURNAL
Artículo2019 Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells JOURNAL OF CELLULAR PHYSIOLOGY
Artículo2019 Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae RNA-A PUBLICATION OF THE RNA SOCIETY
Artículo2019 The Ubiquitin Moiety of Ubi1 Is Required for Productive Expression of Ribosomal Protein eL40 in Saccharomyces cerevisiae Cells
Revisión2018 Feedback regulation of ribosome assembly CURRENT GENETICS
Artículo2018 Ribosomal protein L14 contributes to the early assembly of 60S ribosomal subunits in Saccharomyces cerevisiae NUCLEIC ACIDS RESEARCH
Artículo2018 Rpb5 modulates the RNA polymerase II transition from initiation to elongation by influencing Spt5 association and backtracking BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Revisión2017 Placeholder factors in ribosome biogenesis: please, pave my way MICROBIAL CELL
Artículo2017 The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation NUCLEIC ACIDS RESEARCH
Artículo2016 Role of the yeast ribosomal protein L16 in ribosome biogenesis FEBS JOURNAL
Artículo2016 The eukaryote-specific N-terminal extension of ribosomal protein S31 contributes to the assembly and function of 40S ribosomal subunits NUCLEIC ACIDS RESEARCH
Artículo2015 Dynamics of the Spb4 interactome monitored by affinity purification HOST-PATHOGEN INTERACTIONS: METHODS AND PROTOCOLS
Revisión2015 Functions of Ribosomal Proteins in Assembly of Eukaryotic Ribosomes In Vivo ANNUAL REVIEW OF BIOCHEMISTRY, VOL 84
Artículo2015 Immature large ribosomal subunits containing the 7S pre-rRNA can engage in translation in Saccharomyces cerevisiae RNA BIOLOGY
Revisión2015 Processing of preribosomal RNA in Saccharomyces cerevisiae WILEY INTERDISCIPLINARY REVIEWS-RNA
Artículo2015 The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 to Its Nuclear Pre-60S Assembly Site PLOS GENETICS
Artículo2015 The structure of Erb1-Ytm1 complex reveals the functional importance of a high-affinity binding between two beta-propellers during the assembly of large ribosomal subunits in eukaryotes NUCLEIC ACIDS RESEARCH
Artículo2014 Final Pre-40S Maturation Depends on the Functional Integrity of the 60S Subunit Ribosomal Protein L3 PLOS GENETICS
Artículo2014 The yeast prefoldin-like URI-orthologue Bud27 associates with the RSC nucleosome remodeler and modulates transcription NUCLEIC ACIDS RESEARCH
Artículo2013 Balanced Production of Ribosome Components Is Required for Proper G(1)/S Transition in Saccharomyces cerevisiae JOURNAL OF BIOLOGICAL CHEMISTRY
Ponencia2013 Characterization of the pre-60S ribosomal particles able to translate in Saccharomyces cerevisiae FEBS JOURNAL
Revisión2013 Yeast and human RNA helicases involved in ribosome biogenesis: Current status and perspectives BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Artículo2013 Yeast polypeptide exit tunnel ribosomal proteins L17, L35 and L37 are necessary to recruit late-assembling factors required for 27SB pre-rRNA processing NUCLEIC ACIDS RESEARCH
Artículo2013 Yeast ribosomal protein L7 and its homologue Rlp7 are simultaneously present at distinct sites on pre-60S ribosomal particles NUCLEIC ACIDS RESEARCH
Ponencia2012 Characterization of the pre-60S ribosomal particles able to translate in Saccharomyces cerevisiae FEBS JOURNAL
Ponencia2012 Functional analysis of the role of selected ribosomal proteins in the biogenesis of large ribosomal subunits from the yeast Saccharomyces cerevisiae FEBS JOURNAL
Artículo2012 Saccharomyces cerevisiae Ribosomal Protein L26 Is Not Essential for Ribosome Assembly and Function MOLECULAR AND CELLULAR BIOLOGY
Artículo2012 Yeast Ribosomal Protein L40 Assembles Late into Precursor 60 S Ribosomes and Is Required for Their Cytoplasmic Maturation JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2011 Dynamics of the Putative RNA Helicase Spb4 during Ribosome Assembly in Saccharomyces cerevisiae MOLECULAR AND CELLULAR BIOLOGY
Artículo2011 Nab2 functions in the metabolism of RNA driven by polymerases II and III MOLECULAR BIOLOGY OF THE CELL
Artículo2011 Nop6, a component of 90S pre-ribosomal particles, is required for 40S ribosomal subunit biogenesis in Saccharomyces cerevisiae RNA BIOLOGY
Artículo2010 Ribosomal protein L35 is required for 27SB pre-rRNA processing in Saccharomyces cerevisiae NUCLEIC ACIDS RESEARCH
Artículo2009 Linear ubiquitin fusion to Rps31 and its subsequent cleavage are required for the efficient production and functional integrity of 40S ribosomal subunits MOLECULAR MICROBIOLOGY
Artículo2009 Role and dynamics of the ribosomal protein P0 and its related trans-acting factor Mrt4 during ribosome assembly in Saccharomyces cerevisiae NUCLEIC ACIDS RESEARCH
Artículo2009 The amino terminal domain from Mrt4 protein can functionally replace the RNA binding domain of the ribosomal P0 protein NUCLEIC ACIDS RESEARCH
Artículo2007 Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) reveals a low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis MOLECULAR AND CELLULAR BIOLOGY
Artículo2007 Functional analysis of Saccharomyces cerevisiae ribosomal protein Rpl3p in ribosome synthesis NUCLEIC ACIDS RESEARCH
Artículo2005 The essential WD-repeat protein Rsa4p is required for rRNA processing and intra-nuclear transport of 60S ribosomal subunits NUCLEIC ACIDS RESEARCH
Artículo2004 A membrane transport defect leads to a rapid attenuation of translation initiation in Saccharomyces cerevisiae MOLECULAR CELL
Artículo2004 Has1p, a member of the DEAD-box family, is required for 40S ribosomal subunit biogenesis in Saccharomyces cerevisiae MOLECULAR MICROBIOLOGY
Artículo2004 Npa1p is an essential trans-acting factor required for an early step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae RNA-A PUBLICATION OF THE RNA SOCIETY
Artículo2004 The putative RNA helicase Dbp6p functionally interacts with Rpl3p, Nop8p and the novel trans-acting factor Rsa3p during biogenesis of 60S ribosomal subunits in Saccharomyces cerevisiae GENETICS
Artículo2003 A structural and functional study of plastid RNAs homologous to catalytic bacterial RNase P RNA GENE
Revisión2003 Trans-translation and protein synthesis inhibitors FEMS MICROBIOLOGY LETTERS
Artículo2001 A yeast homolog of chromatin assembly factor 1 is involved in early ribosome assembly CURRENT BIOLOGY
Artículo2001 An antifungal exo-alpha-1,3-glucanase (AGN13.1) from the biocontrol fungus Trichoderma harzianum APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo2001 Increased sensitivity to protein synthesis inhibitors in cells lacking tmRNA RNA-A PUBLICATION OF THE RNA SOCIETY
Artículo1999 Detection of beta-1,6-glucanase isozymes from Trichoderma strains in sodium dodecyl sulphate polyacrylamide gel electrophoresis and isoelectrofocusing gels JOURNAL OF MICROBIOLOGICAL METHODS
Revisión1999 Protein trans-acting factors involved in ribosome biogenesis in Saccharomyces cerevisiae MOLECULAR AND CELLULAR BIOLOGY
Artículo1999 Purification and properties of a basic endo-beta-1,6-glucanase (BGN16.1) from the antagonistic fungus Trichoderma harzianum European Journal of Biochemistry
Artículo1999 Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae NUCLEIC ACIDS RESEARCH
Revisión1999 Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families TRENDS IN BIOCHEMICAL SCIENCES
Artículo1998 16 "Smart" Genetic Screens Methods in Microbiology
Artículo1998 Dbp6p is an essential putative ATP-dependent RNA helicase required for SOS-ribosomal-subunit assembly in Saccharomyces cerevisiae MOLECULAR AND CELLULAR BIOLOGY
Artículo1998 Dob1p (Mtr4p) is a putative ATP-dependent RNA helicase required for the 3 ' end formation of 5.8S rRNA in Saccharomyces cerevisiae EMBO JOURNAL
Artículo1998 Spb4p, an essential putative RNA helicase, is required for a late step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae RNA-A PUBLICATION OF THE RNA SOCIETY
Artículo1997 Fal1p is an essential DEAD-box protein involved in 40S-ribosomal-subunit biogenesis in Saccharomyces cerevisiae MOLECULAR AND CELLULAR BIOLOGY
Artículo1997 The p20 and Ded1 proteins have antagonistic roles in eIFdE-dependent translation in Saccharomyces cerevisiae PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo1996 Retention of Saccharomyces cerevisiae cell wall proteins through a phosphodiester-linked beta-1,3-/beta-1,6-glucan heteropolymer GLYCOBIOLOGY
Artículo1995 A novel endo-β-1,3-glucanase, BGN13.1, involved in the mycoparasitism of Trichoderma harzianum JOURNAL OF BACTERIOLOGY
Artículo1995 Molecular characterization and heterologous expression of an endo-beta-1,6-glucanase gene from the mycoparasitic fungus trichoderma-harzianum MOLECULAR & GENERAL GENETICS
Artículo1995 Primary structure and expression pattern of the 33-kda chitinase gene from the mycoparasitic fungus trichoderma-harzianum CURRENT GENETICS
Artículo1995 Purification and characterization of an Endo-beta-1,6-glucanase from Trichoderma-harzianum that is related to its mycoparasitism JOURNAL OF BACTERIOLOGY
Artículo1994 A putative catabolite-repressed cell-wall protein from the mycoparasitic fungus trichoderma-harzianum MOLECULAR & GENERAL GENETICS
Artículo1994 Cloning and characterization of a chitinase (chit42) cdna from the mycoparasitic fungus trichoderma-harzianum CURRENT GENETICS
Artículo1993 Carbon source control on beta-glucanases, chitobiase and chitinase from trichoderma-harzianum ARCHIVES OF MICROBIOLOGY
Artículo1992 Isolation and characterization of three chitinases from Trichoderma harzianum European Journal of Biochemistry
Capítulo1983 Relación huesped-parásito en plantas infectadas por hongos Temas de microbiología
Purificación y caracterización de hidrolasas implicadas en el microparasitismo de Trichoderma harzianum (1994)
Dirigida por: Antonio Llobell, Tahía Benítez Fernández
Tesis dirigidas/tutorizadas:10
Fecha lectura Título Rol
10/04/2024 Study of Pol5 protein from Saccharomyces cerevisiae and its human ortholog MYBBP1A in ribosome biogenesis Tutor/a, Director/a
07/06/2023 Molecular description of the role of protein synthesis in the cellular response to the treatment with the antitumoral drug Sorafenib in HCC lines Tutor/a, Director/a
18/05/2023 eL15 and eL22 proteins and their functional environments during ribosome assembly in Saccharomyces cerevisiae Director/a, Tutor/a
10/11/2020 RNA helicases in 60s ribosomal subunit biogenesis in Saccharomyces cerevisiae Director/a
11/10/2019 Role of ribosomal proteins eL40 and eS12 in the biogenesis and function of yeast ribosomes Tutor/a, Director/a
15/09/2017 ESTUDIO DEL ENSAMBLAJE RIBOSÓMICO EN SACCHAROMYCES CEREVISAE Director/a
03/12/2014 ROLE OF UBIQUITIN FUSION RIBOSOMAL PROTEINS IN THE SYNTHESIS AND FUNCTION OF YEAST RIBOSOMES Director/a
12/07/2013 ESTUDIO FUNCIONAL DE PROTEÍNAS RIBOSÓMICAS DURANTE LA BIOGÉNESIS DE RIBOSOMAS EN SACCHAROMYCES CEREVISIAE Director/a
18/01/2013 ANÁLISIS FUNCIONAL DE FACTORES DE ACTUACIÓN EN TRANS Y PROTEÍNAS RIBOSÓMICAS DURANTE LA SÍNTESIS DE SUBUNIDADES RIBOSÓMICAS EN SACCHAROMYCES CEREVISIAE Director/a
20/04/2007 PROTEÍNAS QUE INTERACCIONAN CON LA HELICASA DE RNA Dbp6p DURANTE LA SÍNTESIS DE SUBUNIDADES RIBOSÓMICAS 60S EN SACCHAROMYCES CEREVISIAE Director/a

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2014 30/06/2017 Responsable Análisis de los Principios que Rigen el Ensamblaje de los Ribosomas Eucariotas (BFU2013-42958-P) Ministerio de Economía y Competitividad (Nacional)
01/06/2020 31/12/2023 Responsable Comprensión de los Procesos de Síntesis de Ribosomas y Traducción en Organismos Eucariotas (PID2019-103850GB-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
31/01/2008 31/12/2012 Investigador/a Regulación Transcripcional de los Genes Implicados en la Síntesis de Ribosomas: Relación con la Sensibilidad a Drogas Inmunosupresoras e Influencia del Proceso de Ensamblaje de Ribosomas (P07-CVI-02623) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
13/01/2009 31/12/2013 Responsable Síntesis de Ribosomas, Cáncer y Enfermedades Hereditarias. Papel de las Proteínas Ribosómicas y Factores de Ensamblaje de Ribosomas como Posibles Reguladores de la Proliferación Celular (P08-CVI-03508) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/01/2011 30/06/2014 Responsable Estudio del Ensamblaje Ribosómico en Saccharomyces Cerevisiae (BFU2010-15690) Ministerio de Ciencia e Innovación (Nacional)
01/01/2022 31/05/2023 Responsable Mecanismo de acción de la ribotoxina alfa sarcina y función molecular de las proteínas ortologas Pol5 y MYBBP1A en la síntesis y función del ribosoma eucariótico (US-1380394) Consejería de Economía, Conocimiento, Empresas y Universidad (Autonómico)
01/12/2022 31/08/2025 Responsable Nuevas estrategias basadas en la traducción para la optimización de una economía circular basada en hongos (TED2021-129601B-I00) Ministerio de Ciencia e Innovación (Nacional)
30/12/2016 31/12/2020 Responsable Ensamblaje de Subunidades Ribosómicas Eucarióticas: Análisis de Factores de Ensamblaje y de Proteínas Ribosómicas (BFU2016-75352-P) Ministerio de Economía y Competitividad (Nacional)
05/10/2021 30/06/2023 Responsable Homeostasis of ribosome production in eukaryotes (P20_00581) Consejería de Economía, Conocimiento, Empresas y Universidad (Autonómico)
28/12/2001 27/12/2004 Responsable Análisis bioquímico y genético de la biogénesis del ribosoma en saccharomyces cerevisiae (BMC2001-2660) Ministerio de Ciencia y Tecnología (Nacional)
01/10/2007 04/10/2010 Responsable Análisis funcional del ensamblaje reibosómico en Saccharomyces cerevisiae (BFU2007-60151) Ministerio de Educación y Ciencia (Nacional)
01/03/2022 29/02/2024 Responsable A Riboescaper study: Protein synthesis driven by deficiently assembled ribosomes - RiboEscapers (H2020-MSCA-IF-2020) Comisión Europea (Europeo)
30/01/2014 31/07/2019 Investigador/a Latencia de la Infección por VIH-1: Mecanismos Moleculares y Estrategias de Terapia Génica Mediante Nanopartículas Dirigidas (P12-BIO-1938) Consejería de Economía, Innovación y Ciencia (Autonómico)
01/03/2006 28/02/2009 Investigador/a Flow Focusing y Electro-Flow Focusing en Biomedicina y Biotecnología (EXC/2005/TEP-1190) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
01/01/2003 31/12/2005 Investigador/a Nuevas técnicas de genómica funcional: análisis mediante DNA-arrays de potenciales genes blanco de los immunosupresores en células linfoides y granulocíticas. (PI021363) Ministerio de Sanidad y Consumo (Instituto de Salud Carlos III) (Nacional)
13/12/2004 13/12/2007 Responsable Análisis funcional de la biogénesis del ribosoma en saccharomyces cerevisiae (BFU2004-00252) Ministerio de Ciencia y Tecnología (Nacional)
01/09/2023 31/08/2026 Responsable Contribución molecular de helicasas de RNA y proteínas ribosómicas al ensamblaje del ribosoma eucariótico y sus consecuencias en el proceso de traducción (PID2022-136564NB-I00) Ministerio de Ciencia e Innovación (Nacional)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2010 30/06/2012 Responsable Role and dynamics of trans-acting factors related to ribosomal proteins during ribosome assembly in eukaryotes (FR2009-0102) Ministerio de Ciencia e Innovación (Nacional)
01/01/2007 31/12/2008 Responsable RNA Helicases: understanding their function during ribosome biogenesis (HF2006-0153) Ministerio de Educación y Ciencia (Nacional)
El investigador no tiene ningún resultado de investigación asociado