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MBC - Prisma - Unidad de Bibliometría

BIOLOGIA MOLECULAR DEL CANCER - CTS-025 (MBC)

Tipo de colectivo: Grupo de investigación
Estado: Grupo definitivo
Ámbito: Andalucía
Instituciones: Sistema Sanitario Público de Andalucía. Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla (FISEVI)
Fecha de creación: 26/09/2011

Investiga en

Palabras clave
Líneas de investigación
Resumen
Nombre Rol
García Heredia, José Manuel Miembro
Marín López, Juan José Miembro
Tipo Año Título Fuente
Ponencia2023 A Feature Selection and Association Rule Approach to Identify Genes Associated with Metastasis and Low Survival in Sarcoma Lecture Notes in Computer Science
Letter2023 A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules. Signal Transduction and Targeted Therapy
Artículo2023 Diseño de campañas de salud pública, un aprendizaje basado en problemas RESCIFAR Revista Española de Ciencias Farmacéuticas
Revisión2023 The multitasker protein: a look at the multiple capabilities of NUMB Cells
Resumen congreso2022 MAP17 promotes metastasis in hepatocellular carcinoma by modulating the epithelial-mesenchymal-amoeboid transition JOURNAL OF HEPATOLOGY
Artículo2020 Autoencoded DNA methylation data to predict breast cancer recurrence: machine learning models and gene-weight significance Artificial Intelligence in Medicine
Artículo2020 Breast tumor cells promotes the horizontal propagation of EMT, stemness, and metastasis by transferring the MAP17 protein between subsets of neoplastic cells Oncogenesis
Artículo2020 PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208 Cells
Revisión2020 Role of Mitochondria in Cancer Stem Cell Resistance Cells
Artículo2020 Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment Signal Transduction and Targeted Therapy
Artículo2019 New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Revisión2018 Dr. Jekyll and Mr. Hyde: MAP17's up-regulation, a crosspoint in cancer and inflammatory diseases MOLECULAR CANCER
Artículo2018 MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Artículo2018 NUMB and NUMBL differences in gene regulation ONCOTARGET
Artículo2017 Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer ONCOTARGET
Artículo2017 Machine learning techniques to discover genes with potential prognosis role in Alzheimer's disease using different biological sources INFORMATION FUSION
Artículo2017 The Cargo Protein MAP17 (PDZK1IP1) Regulates the Cancer Stem Cell Pool Activating the Notch Pathway by Abducting NUMB CLINICAL CANCER RESEARCH
Artículo2017 The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment ONCOTARGET
Ponencia2016 Discovery of Genes Implied in Cancer by Genetic Algorithms and Association Rules HYBRID ARTIFICIAL INTELLIGENT SYSTEMS
Artículo2016 Efficacy of bortezomib in sarcomas with high levels of MAP17 (PDZK1IP1) ONCOTARGET
Artículo2016 Loss of the tumor suppressor spinophilin (PPP1R9B) increases the cancer stem cell population in breast tumors ONCOGENE
Artículo2016 Numb-Like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy ONCOTARGET
Artículo2015 Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial respiratory chain ONCOTARGET
Artículo2015 Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA ONCOTARGET
Artículo2015 Genetic modification of hypoxia signaling in animal models and its effect on cancer CLINICAL & TRANSLATIONAL ONCOLOGY
Artículo2015 High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer ONCOTARGET
Ponencia2013 How redox proteins form transient complexes in photosynthesis and respiration EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Artículo2013 MAP17 and SGLT1 Protein Expression Levels as Prognostic Markers for Cervical Tumor Patient Survival PLOS ONE
Revisión2013 Recent Methodological Advances in the Analysis of Protein Tyrosine Nitration CHEMPHYSCHEM
Artículo2012 A non-damaging method to analyze the configuration and dynamics of nitrotyrosines in proteins CHEMISTRY-A EUROPEAN JOURNAL
Ponencia2012 Construction of a mimetic mutant of cytochrome c phosphorylated at tyrosine 48 to further study its biological role in the transition from cell life to death FEBS JOURNAL
Ponencia2012 Cytochrome c(1): an old protein with novel functions FEBS JOURNAL
Ponencia2012 High spin nitrated cytochrome c is specifically degraded inside the cells FEBS JOURNAL
Artículo2012 p38 alpha limits the contribution of MAP17 to cancer progression in breast tumors ONCOGENE
Artículo2012 Perturbation of the Redox Site Structure of Cytochrome c Variants upon Tyrosine Nitration JOURNAL OF PHYSICAL CHEMISTRY B
Artículo2012 Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome FEBS LETTERS
Revisión2011 Cellular senescence as a target in cancer control Journal of Aging Research
Artículo2011 Cytochrome c signalosome in mitochondria EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Artículo2011 Down-regulation of spinophilin in lung tumours contributes to tumourigenesis JOURNAL OF PATHOLOGY
Artículo2011 Nitration of tyrosines 46 and 48 induces the specific degradation of cytochrome c upon change of the heme iron state to high-spin BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Ponencia2011 Tyrosine phosphorylation turns alkaline transition into a biologically relevant process and makes human cytochrome c behave as an anti-apoptotic switch FEBS JOURNAL
Artículo2011 Tyrosine phosphorylation turns alkaline transition into a biologically relevant process and makes human cytochrome c behave as an anti-apoptotic switch Journal of Biological Inorganic Chemistry
Artículo2010 Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Ponencia2010 Structural and functional changes induced by tyrosine nitration in cytochrome c, a bi-functional protein BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Artículo2010 Targeting Cancer by Inducing Senescence The Open Enzyme Inhibition Journal
Capítulo2010 Uso del tiempo de las mujeres: ventajas y prejuicios para la salud Investigaciones multidisciplinares en género: II Congreso Universitario Nacional
Ponencia2009 Structural and functional features of post-translationally modified cytochrome c, a bifunctional protein FEBS JOURNAL
Artículo2008 Acetylsalicylic acid induces programmed cell death in Arabidopsis cell cultures PLANTA
Artículo2008 Effect of Nitration on the Physicochemical and Kinetic Features of Wild-Type and Monotyrosine Mutants of Human Respiratory Cytochrome c BIOCHEMISTRY
Artículo2006 A comparative kinetic analysis of the reactivity of plant, horse, and human respiratory cytochrome c towards cytochrome c oxidase BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Artículo1993 Fertile females of the mole Talpa occidentalis are phenotypic intersexes with ovotestes DEVELOPMENT

Proyectos de Investigación

Fecha de inicio Fecha de fin Denominación Agencia financiadora Importe concedido
01/01/2013 31/12/2015 Desvelando Nuevas Redes de Proteínas que Interaccionan con el Citocromo C: Análisis Comparativo Estructural y Funcional (BFU2012-31670) Ministerio de Economía y Competitividad (Nacional) 219.960,00 €
01/01/2010 31/12/2012 Bases estructurales, reconocimiento molecular y análisis evolutivo del citocromo C, una proteína bifuncional modificada post- tradiccionalmente (BFU2009-07190) Ministerio de Ciencia e Innovación (Nacional) 363.000,00 €
13/01/2009 31/12/2013 Búsqueda Estructural de Metaloproteínas Vegetales Capaces de Inhibir la Invasión Celular y Posterior Desarrollo del Parásito de la Malaria (P08-CVI-03876) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico) 259.923,68 €
01/10/2006 30/09/2009 Análisis evolutivo y relación estructura-función del citocromo c y su equivalente metabólico, el citocromo c6, como inductores de muerte celular programada (BFU2006-01361) Ministerio de Educación y Ciencia (Nacional) 440.803,00 €

Patentes

Nº Solicitud Fecha Solicitud Fecha Concesión Nombre
P200402723 05/01/2004 16/12/2009 Construcción génica que codifica para el citocromo c y procedimiento de obtención.