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Antonio Leal Plaza

Catedrático de Universidad
alplaza@us.es
Área de conocimiento: Fisiología
Departamento: Fisiología Médica y Biofísica
Grupo: FISICA MEDICA - CTS-233 (Universidad de Sevilla)
Centro mixto: Instituto de Biomedicina de Sevilla (IBIS)
Prog. doctorado: BIOLOGÍA MOLECULAR, BIOMEDICINA E INVESTIGACIÓN CLÍNICA

Investiga en

Tipo Año Título Fuente
Artículo2022 Clinical feasibility study of gold nanoparticles as theragnostic agents for precision radiotherapy. Biomedicines
Artículo2022 Clinical viability of boron neutron capture therapy for personalized radiation treatment CANCERS
Resumen congreso2022 Compact System for 4D Treatment Planning and Dose Verification Based On Flexible Movement Medical physics
Artículo2022 Implications of the harmonization of [18F]FDG-PET/CT imaging for response assessment of treatment in radiotherapy planning Tomography
Artículo2022 Modified Geometry of 106Ru Asymmetric Eye Plaques to Improve Dosimetric Calculations in Ophthalmic Brachytherapy Journal of personalized medicine
Resumen congreso2022 NanoLIC: a liquid-filled ionization chamber for experimental verification of dose enhancement with gold nanoparticles Medical physics
Artículo2021 Robustness of PET radiomics features: Impact of co-registration with MRI APPLIED SCIENCES-BASEL
Artículo2019 Accurate, robust and harmonized implementation of morpho-functional imaging in treatment planning for personalized radiotherapy PLOS ONE
Artículo2017 Application of EARL (ResEARch 4 Life (R)) protocols for [F-18]FDG-PET/CT clinical and research studies. A roadmap towards exact recovery coefficient NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
Artículo2017 Clinical implementation of combined modulated electron and photon beams with conventional MLC for accelerated partial breast irradiation RADIOTHERAPY AND ONCOLOGY
Artículo2017 Dose painting by means of Monte Carlo treatment planning at the voxel level PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
Artículo2016 3D VMAT Verification Based on Monte Carlo Log File Simulation with Experimental Feedback from Film Dosimetry PLOS ONE
Resumen congreso2015 CARMEN: A MatLab-Based Research Platform for Monte Carlo Treatment Planning (MCTP) and Customized System for Planning Evaluation Medical physics
Resumen congreso2015 Outcomes and Toxicities From a Clinical Trial of APBI Using MERT plus IMRT with the Same XMLC Medical physics
Resumen congreso2015 QuAArC: A 3D VMAT QA System Based On Radiochromic Film and Monte Carlo Simulation of Log Files Medical physics
Ponencia2014 Clinical implementation of APBI using combined modulated electron and photon beams by means of the same MLC device RADIOTHERAPY AND ONCOLOGY
Artículo2014 Dosimetric effect by shallow air cavities in high energy electron beams PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
Artículo2014 MCTP system model based on linear programming optimization of apertures obtained from sequencing patient image data maps Medical physics
Ponencia2014 Prone accelerated partial breast irradiation with MERT+IMRT using a Monte Carlo treatment planning system RADIOTHERAPY AND ONCOLOGY
Ponencia2014 VMAT verification, commissioning and QA based on MC simulation RADIOTHERAPY AND ONCOLOGY
Artículo2013 Dose-Free Monitoring of Radiotherapy Treatments With Scattered Photons: First Experimental Results at a 6-MV Linac IEEE TRANSACTIONS ON NUCLEAR SCIENCE
Editorial2013 Special section: Selected papers from the Third European Workshop on Monte Carlo Treatment Planning (MCTP2012) PREFACE PHYSICS IN MEDICINE AND BIOLOGY
Artículo2012 Combined modulated electron and photon beams planned by a Monte-Carlo-based optimization procedure for accelerated partial breast irradiation PHYSICS IN MEDICINE AND BIOLOGY
Ponencia2012 Dose-free monitoring of radiotherapy treatments with scattered photons: First experimental results at a 6-MV Linac IEEE Nuclear Science Symposium and Medical Imaging Conference
Resumen congreso2010 DOSE OPTIMIZATION BASED ON LINEAR PROGRAMMING IMPLEMENTED IN A MONTE CARLO TREATMENT PLANNING SYSTEM RADIOTHERAPY AND ONCOLOGY
Resumen congreso2010 Evaluation of the efficacy of modulated electron radiation therapy in combination with imrt for the planning of novel breast cancer treatments RADIOTHERAPY AND ONCOLOGY
Artículo2010 Intensity- and energy-modulated electron radiotherapy by means of an xMLC for head and neck shallow tumors PHYSICS IN MEDICINE AND BIOLOGY
Ponencia2010 Mixed Electron and Photon Beams Modulated by the XMLC for Partial Breast Irradiation Medical physics
Artículo2009 Clinical comparative study of dose - volume and equivalent uniform dose based predictions in post radiotherapy acute complications Acta oncologica
Artículo2009 Modulated electron radiotherapy treatment planning using a photon multileaf collimator for post-mastectomized chest walls RADIOTHERAPY AND ONCOLOGY
Artículo2008 The change of response of ionization chambers in the penumbra and transmission regions: impact for IMRT verification MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
Artículo2007 Conversion of CT numbers into tissue parameters for Monte Carlo dose calculations: a multi-centre study PHYSICS IN MEDICINE AND BIOLOGY
Ponencia2007 Evaluation of air cavity effect for electron beams dose calculations using Monte Carlo method RADIOTHERAPY AND ONCOLOGY
Artículo2007 Evaluation of uncertainty-based stopping criteria for Monte Carlo calculations of intensity-modulated radiotherapy and arc therapy patient dose distributions International Journal of Radiation: Oncology - Biology - Physics
Artículo2007 Uncertainty estimation in intensity-modulated radiotherapy absolute dosimetry verification International Journal of Radiation: Oncology - Biology - Physics
Ponencia2006 Advanced mixed beam radiotherapy for breast and head and neck Medical physics
Artículo2006 Characterization of megavoltage electron beams delivered through a photon multi-leaf collimator (pMLC) PHYSICS IN MEDICINE AND BIOLOGY
Ponencia2005 Characterization of a new target in a Siemens Primus linac by means of Monte Carlo simulation. RADIOTHERAPY AND ONCOLOGY
Ponencia2005 Conversion of CT numbers into tissue parameters for Monte Carlo dose calculations RADIOTHERAPY AND ONCOLOGY
Ponencia2005 Determination of the most probable ways followed by photons in a 6MV Siemens Primus linac. RADIOTHERAPY AND ONCOLOGY
Ponencia2005 Dose error contribution in film dosimetry due to interference effect using a document scanner RADIOTHERAPY AND ONCOLOGY
Ponencia2005 Energy and intensity modulated electron radiation therapy by means of a Monte Carlo routine RADIOTHERAPY AND ONCOLOGY
Ponencia2005 Energy and intensity modulated electron radiation therapy using a Monte Carlo optimization procedure Medical physics
Ponencia2005 Evaluation of the probability density of the Lyman's and Kallman's relative seriality parameters NTCP models of two endpoints concerning the rectum and the bladder. RADIOTHERAPY AND ONCOLOGY
Ponencia2005 Leakage evaluation as a function of the tip angle for a non tongue and groove multileaf collimator using Monte Carlo simulation RADIOTHERAPY AND ONCOLOGY
Artículo2005 Micro ionization chamber dosimetry in IMRT verification: Clinical implications of dosimetric errors in the PTV RADIOTHERAPY AND ONCOLOGY
Artículo2005 Microionization chamber for reference dosimetry in IMRT verification: clinical implications on OAR dosimetric errors PHYSICS IN MEDICINE AND BIOLOGY
Ponencia2005 Monte Carlo study on double-focused leaf end influence in photon leakage RADIOTHERAPY AND ONCOLOGY
Ponencia2005 Monte Carlo study on IMRT and Radiosurgery dosimetry performed by ionization chamber RADIOTHERAPY AND ONCOLOGY
Ponencia2005 Some transmission influencing factors of a MLC analyzed by EGSnrc Monte Carlo code RADIOTHERAPY AND ONCOLOGY
Ponencia2005 Use of Mutual Information for solving image superposition-linked issues in IMRT verification RADIOTHERAPY AND ONCOLOGY
Artículo2004 An EGSnrc Monte Carlo study of the microionization chamber for reference dosimetry of narrow irregular IMRT beamlets Medical physics
Ponencia2004 Correction factor for a pinpoint ionisation chamber in no reference conditions RADIOTHERAPY AND ONCOLOGY
Ponencia2004 IMRT verification tool in dynamic treatment using full Monte Carlo simulation RADIOTHERAPY AND ONCOLOGY
Artículo2004 MLC leaf width impact on the clinical dose distribution: A Monte Carlo approach International Journal of Radiation: Oncology - Biology - Physics
Artículo2004 Monte Carlo simulation of complex radiotherapy treatments COMPUTING IN SCIENCE & ENGINEERING
Ponencia2003 Absolute dosimetry in the penumbra of the narrow IMRT beamlet RADIOTHERAPY AND ONCOLOGY
Ponencia2003 Comparison of Monte Carlo simulation and TPS calculation of radiosurgery treatment DVHS by means of TCP and NTCP parameters RADIOTHERAPY AND ONCOLOGY
Ponencia2003 Dynamic IMRT segment optimisation for a faster MC verification RADIOTHERAPY AND ONCOLOGY
Ponencia2003 Influence of the MLC leaf width on the dose distribution: a Monte Carlo study RADIOTHERAPY AND ONCOLOGY
Artículo2003 Investigation of radiosurgical beam profiles using Monte Carlo method Medical Dosimetry
Artículo2003 Ionization chamber dosimetry of small photon fields: a Monte Carlo study on stopping-power ratios for radiosurgery and IMRT beams PHYSICS IN MEDICINE AND BIOLOGY
Ponencia2003 Radiobiological criteria for prostate IMRT treatment planning selection RADIOTHERAPY AND ONCOLOGY
Artículo2003 Routine IMRT verification by means of an automated Monte Carlo simulation system International Journal of Radiation: Oncology - Biology - Physics
Artículo2003 Total skin electron therapy treatment verification: Monte Carlo simulation and beam characteristics of large non-standard electron fields PHYSICS IN MEDICINE AND BIOLOGY
Ponencia2003 Total skin electron therapy treatment: Monte Carlo verification and beam characteristics RADIOTHERAPY AND ONCOLOGY
Ponencia2002 A new tool for routine analysis of QA in IMRT RADIOTHERAPY AND ONCOLOGY
Ponencia2002 Monte Carlo based study of the influence of double-focusing on dose distribution in IMRT treatments RADIOTHERAPY AND ONCOLOGY
Ponencia2002 MONTE CARLO CALCULATIONS FOR THE DOSIMETRY OF NARROW PHOTON BEAMS IN RADIOSURGERY IMRT RADIOTHERAPY AND ONCOLOGY
Artículo2002 Monte carlo clinical dosimetry REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY
Revisión2002 Physical and clinical dosimetry in radiosurgery using Monte Carlo Oncología
Ponencia2002 Poster Monte Carlo simulation of a 6 MeV beam for non-standard electron treatments RADIOTHERAPY AND ONCOLOGY
Artículo2002 Radiosurgery: Monte Carlo method Oncología
Revisión2002 Tele-radiosurgery Oncología
Artículo2001 A Monte Carlo approach for small electron beam dosimetry RADIOTHERAPY AND ONCOLOGY
Ponencia2001 Automated assessment of IMRT treatments RADIOTHERAPY AND ONCOLOGY
Ponencia2001 Distributed processing for CPU time optimisation in Monte Carlo simulation PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
Artículo2001 Distributed processing for CPU time optimisation in Monte Carlo simulation PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
Ponencia2001 Monte Carlo as a tool for treatment planning verification PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
Artículo2001 Monte Carlo as a tool for treatment planning verification PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
Ponencia2001 Monte Carlo conformal treatment planning as an independent assessment Advanced Monte Carlo for Radiation Physics, Particle Transport Simulation and Applications
Ponencia2001 Monte Carlo Conformal Treatment Planning as an Independent Assessment Advanced Monte Carlo for Radiation Physics, Particle Transport Simulation and Applications
Ponencia2001 Monte Carlo Dose Distributions for Radiosurgery Advanced Monte Carlo for Radiation Physics, Particle Transport Simulation and Applications
Ponencia2001 Monte Carlo dose distributions for radiosurgery Advanced Monte Carlo for Radiation Physics, Particle Transport Simulation and Applications
Ponencia2001 Monte Carlo physical dosimetry for small photon beams Advanced Monte Carlo for Radiation Physics, Particle Transport Simulation and Applications
Ponencia2001 Monte Carlo simulation of an arc therapy treatment by means of a PC distribution model Advanced Monte Carlo for Radiation Physics, Particle Transport Simulation and Applications
Ponencia2001 Monte Carlo Simulation of an Arc Therapy Treatment by Means of a PC Distribution Model Advanced Monte Carlo for Radiation Physics, Particle Transport Simulation and Applications
Ponencia2001 PC-based process distribution to solve iterative Monte Carlo Simulations in physical dosimetry Advanced Monte Carlo for Radiation Physics, Particle Transport Simulation and Applications
Ponencia2001 PC-Based Process Distribution to Solve Iterative Monte Carlo Simulations in Physical Dosimetry Advanced Monte Carlo for Radiation Physics, Particle Transport Simulation and Applications
Ponencia2001 Physical and clinical dosimetry by means of Monte Carlo using a process distribution tool REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY
Ponencia2001 Total body irradiation as conditioning for bone marrow transplantation: current state of the TBI-EBMT registry RADIOTHERAPY AND ONCOLOGY
Ponencia2001 Weak points of an inverse treatment planning system RADIOTHERAPY AND ONCOLOGY
Ponencia2000 Computational methods for treatment verification: the Full Monte Carlo contribution. USE OF COMPUTERS IN RADIATION THERAPY
Ponencia2000 Current sate of the EBMT-TBI registry (1999) BONE MARROW TRANSPLANTATION
Artículo1999 A conformal technique for a ring shaped conjunctive lymphoma treatment RADIOTHERAPY AND ONCOLOGY
Artículo1999 Monte Carlo as a tool to evaluate radiosurgery dosimetric data and treatment planning. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS

Tesis dirigidas/tutorizadas:10
Fecha lectura Título Rol
20/03/2024 Feasibility Evaluation of the Use of Gold Nanoparticles as Theragnostic Agents for Personalized and Precision Radiotherapy Director/a, Tutor/a
04/11/2022 Transcriptional Regulation and Epigenetic Mechanisms Underlying Host-Parasite Interactions in Human Malaria Tutor/a
28/09/2018 IMPLEMENTACIÓN PRECISA Y NORMALIZADA DE IMÁGENES MORFOFUNCIONALES EN LA PLANIFICACIÓN DE TRATAMIENTOS PARA LA RADIOTERAPIA PERSONALIZADA Tutor/a, Director/a
02/12/2016 EVALUATION OF VOLUMETRIC MODULATED ARC THERAPY AND QUALITY ASSURANCE BASED ON MONTE CARLO SIMULATION Director/a
19/06/2015 PLANIFICACIÓN RADIOTERÁPICA DE INTENSIDAD MODULADA BASADA EN UN MODELO DE SIMULACIÓN EXPLÍCITA DEL TRANSPORTE DE PARTÍCULAS MEDIANTE OPTIMIZACIÓN POR IMÁGEN MÉDICA Director/a
08/06/2012 APLICACIÓN DE HACES COMBINADOS DE FOTONES Y ELECTRONES MODULADOS PARA EL TRATAMIENTO RADIOTERÁPICO CONSERVADOR DE CÁNCER DE MAMA Director/a
12/12/2008 MODULACIÓN DE HACES DE ELECTRONES PARA EL TRATAMIENTO DE TUMORES SUPERFICIALES MEDIANTE PLANIFICACIÓN MONTE CARLO Director/a
04/07/2008 REDUCCIÓN DE LA DOSIS INTEGRAL EN LOS TRATAMIENTOS RADIOTERÁPICOS BASADOS EN INTENSIDAD MODULADA DINÁMICA: VERIFICACIÓN MEDIANTE EL MÉTODO DE MONTE CARLO Director/a
15/01/2007 Simulación mediante Monte Carlo de un haz de 6 MeV de electrones para la terapia con irradiación cutánea total Director/a
20/05/2006 Planificación de tratamientos radioterápicos con intensidad modulada basados en la perspectiva de la anatomía que tiene el haz para su conformación y fluencia Director/a

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2009 31/12/2011 Responsable Radioterapia con haces de electrones modulados en combinación con IMRT: planificación basada en Monte Carlo (SAF2008-03692) Ministerio de Ciencia e Innovación (Nacional)
03/02/2010 03/08/2013 Responsable Radioterapia con Haces de Electrones Modulados en Combinación con IMRT para el Tratamiento de Cáncer de Mama y Cabeza- Cuello (P09-CVI-4885) Junta de Andalucía (Consejería de Innovación, Ciencia y Empresas) (Autonómico)
01/01/2012 31/07/2015 Responsable Desarrollo Teórico y Evaluación Clínica de la Técnica Radioterápica con Arcoterapia Volumétrica Modulada (Vmat) (SAF2011-27116) Ministerio de Ciencia e Innovación (Nacional)
01/01/2019 30/09/2022 Responsable Aproximación a la Radioterapia Personalizada a Través del Uso de Nanopartículas como Agente Teragnóstico en Tratamientos Hipofraccionados bajo Condiciones de Estrés Oxidativo (RTI2018-098656-B-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
05/10/2021 31/03/2023 Responsable Experimental evaluation of the theragnostic possibilities of gold nanoplatforms in radiotherapy (P20_01053) Consejería de Economía, Conocimiento, Empresas y Universidad (Autonómico)
04/10/2003 03/04/2005 Investigador/a Optimización con técnicas de Monte Carlo del diseño de un acelerador lineal clínico y del cálculo de la distribución de la dosis depositada en tratamientos radioterápicos con intensidad modulada (PTR1995-0729-OP) Ministerio de Ciencia y Tecnología (Nacional)
01/08/2007 02/02/2009 Investigador/a Diseño e implementación de un detector in vivo para la valoración de la contaminación neutrónica en pacientes sometidos a terapia de fotones de alta energía (PET2006_0412) Ministerio de Educación y Ciencia (Nacional)
01/01/2012 31/12/2014 Responsable Evaluación clínica y desarrollo de un modelo de optimización para la aplicación de la técnica radioterápica VMAT (IPT-2011-1480-900000) Ministerio de Ciencia e Innovación (Nacional)
01/12/2023 30/11/2026 Responsable Viabilidad clínica de las nanopartículas de oro como agente teragnóstico para una radioterapia de precisión (PRYES235123LEA) Fundación Científica Asociación Española Contra el Cancer (Nacional)

Contratos

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
15/10/2014 28/02/2015 Responsable En el marco del proyecto FEDER INTERCONECTA - GASP (Desarrollo de un Gantry Supercdonductor para el Tratamiento de Tumores con Técnicas de Protonterapia) (2351/0518) TTI Norte S.L. (Desconocido)
09/04/2001 09/04/2003 Investigador/a Desarrollo de modelos dosimétricos 3D para la simulación de técnicas especiales de radioterapia (realización del estudio en materia de oncología radioterapica, dosimetría física y clínica de la irradiación cutánea total con electrones en el acelerador lineal primus) (SI-058/01) Hospital Universitario Virgen Macarena (Desconocido)
07/09/2011 31/12/2014 Responsable Contrato de colaboración entre Exploraciones Radiológicas Especiales, S.A. y la Fundación de Investigación de la Universidad de Sevilla. (1467/0518) ERESA (Desconocido)
01/01/2008 31/12/2008 Investigador/a IMRT: Valoración de la contaminación neutrónica (0034/0027) Hospital Universitario Virgen Macarena (Desconocido)
25/07/2007 25/09/2008 Responsable Sistema de fusión de imágenes PET y resonancia magnética para el diagnóstico médico (SI-010/08) Orienta Ingeniería S.L. (Desconocido)
01/11/2009 30/06/2012 Investigador/a Medida de las dosis neutrónicas en pacientes sometidos a radioterapia para la selección óptima de la estrategia de tratamiento que permita la reducción del riesgo radiológico de padecer segundo cáncer (0549/0027) Consejo de Seguridad Nuclear (Desconocido)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
15/05/2012 18/05/2012 Responsable Third European Workshop on Monte Carlo Treatment Planning (PP2012-01-009) Universidad de Sevilla (Local)

Transferencia de Conocimiento

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/02/2020 31/10/2021 Responsable Sistema 4uArC de verificación y control de calidad 4D para el tratamiento radioterápico extracraneal estereotáxico (SBRT) específico del paciente con lesión sometida a movimiento respiratorio (AT17_5925_USE) Consejería de Economía, Conocimiento, Empresas y Universidad (Autonómico)
El investigador no tiene ningún resultado de investigación asociado