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Rocío Martínez de Pablos

Catedrática de Universidad
depablos@us.es
Área de conocimiento: Bioquímica y Biología Molecular
Departamento: Bioquímica y Biología Molecular
Grupo: MECANISMOS DE MUERTE CELULAR EN ENFERMEDADES NEURODEGENERATIVAS - BIO-113 (Universidad de Sevilla)
Centro mixto: Instituto de Biomedicina de Sevilla (IBIS)
Prog. doctorado: FARMACIA

Investiga en

Tipo Año Título Fuente
Artículo2024 Analysis of patient referrals from primary care to ophthalmology. The role of the optometrist Journal of Optometry
Artículo2024 Dopaminergic neurons lacking Caspase-3 avoid apoptosis but undergo necrosis after MPTP treatment inducing a Galectin-3-dependent selective microglial phagocytic response CELL DEATH & DISEASE
Artículo2024 Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
Revisión2024 Standardization through education of molecular pathology: a spotlight on the European Masters in Molecular Pathology VIRCHOWS ARCHIV
Artículo2023 Actin Polymerization Defects Induce Mitochondrial Dysfunction in Cellular Models of Nemaline Myopathies ANTIOXIDANTS
Artículo2023 Caecum OX40+CD4 T-cell subset associates with mucosal damage and key markers of disease in treated HIV-infection JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
Artículo2023 Microglial Caspase-3 is essential for modulating hippocampal neurogenesis. BRAIN BEHAVIOR AND IMMUNITY
Resumen congreso2023 The deletion of Galectin-3 Reduces the Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon in two models of peripheral inflammation. GLIA
Artículo2022 Gal3 Plays a Deleterious Role in a Mouse Model of Endotoxemia INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2022 Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration CELL DEATH & DISEASE
Revisión2022 Inflammatory animal models of Parkinson's disease JOURNAL OF PARKINSONS DISEASE
Letter2022 Partial restoration of gut-mucosal dysbiosis in late-treated HIV-infected subjects with CD4 T-cell recovery Clinical and translational medicine
Corrección2022 The absence of caspase-8 in the dopaminergic system leads to mild autism-like behavior (vol 10, 839715, 2022) FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Artículo2022 The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Editorial2021 Editorial: Neurodegeneration: From Genetics to Molecules (Part II) FRONTIERS IN CELLULAR NEUROSCIENCE
Artículo2021 Galectin-3 deletion reduces LPS and acute colitis-induced pro-inflammatory microglial activation in the ventral mesencephalon FRONTIERS IN PHARMACOLOGY
Artículo2021 Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Artículo2021 Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma ONCOGENE
Artículo2020 Hydroxytyrosol decreases lps-and α-synuclein-induced microglial activation in vitro ANTIOXIDANTS
Capítulo2020 Microglia-mediated neuroinflammation and Mediterranean diet The Mediterranean Diet: An Evidence-Based Approach
Revisión2019 Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases PHARMACOLOGICAL RESEARCH
Revisión2019 Reformulating Pro-Oxidant Microglia in Neurodegeneration JOURNAL OF CLINICAL MEDICINE
Artículo2018 Divergent Effects of Metformin on an Inflammatory Model of Parkinson's Disease FRONTIERS IN CELLULAR NEUROSCIENCE
Artículo2018 Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson's Disease FRONTIERS IN CELLULAR NEUROSCIENCE
Revisión2018 Phenolic Compounds Characteristic of the Mediterranean Diet in Mitigating Microglia-Mediated Neuroinflammation FRONTIERS IN CELLULAR NEUROSCIENCE
Revisión2018 Potential Use of Nanomedicine for the Anti-inflammatory Treatment of Neurodegenerative Diseases CURRENT PHARMACEUTICAL DESIGN
Resumen congreso2017 Involvement of caspase-8 in microglial activation mediated by B-amyloid GLIA
Ponencia2017 Pheripheral inflamation exacerbates neuronal death in the mptp model of Parkinson's disease through microglial activation GLIA
Ponencia2017 Ulcerative colitis induces the activation of microglia in the ventral mesencephalon along with dopaminergic neuronal death GLIA
Artículo2016 Chronic stress alters the expression levels of longevity-related genes in the rat hippocampus NEUROCHEMISTRY INTERNATIONAL
Artículo2016 Creating a Rat Model of Chronic Variate Stress Bio-Protocol
Artículo2016 Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system TOXICOLOGY AND APPLIED PHARMACOLOGY
Artículo2016 Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke ACTA NEUROPATHOLOGICA COMMUNICATIONS
Revisión2015 Collateral Damage: Contribution of Peripheral Inflammation to Neurodegenerative Diseases CURRENT TOPICS IN MEDICINAL CHEMISTRY
Artículo2015 Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism JOURNAL OF NEUROINFLAMMATION
Revisión2015 Relevance of chronic stress and the two faces of microglia in Parkinson's disease FRONTIERS IN CELLULAR NEUROSCIENCE
Artículo2015 Synergistic Deleterious Effect of Chronic Stress and Sodium Azide in the Mouse Hippocampus CHEMICAL RESEARCH IN TOXICOLOGY
Artículo2014 Chronic stress as a risk factor for Alzheimer's disease REVIEWS IN THE NEUROSCIENCES
Artículo2014 Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation JOURNAL OF NEUROINFLAMMATION
Ponencia2014 Implantación del Plan de Orientación y Acción Tutorial en la Facultad de Farmacia de la Universidad de Sevilla ARS PHARMACEUTICA
Artículo2014 In vivo Effect of Apomorphine and Haloperidol on MPP+ Neurotoxicity PHARMACOLOGY
Artículo2014 Role of dopamine in the recruitment of immune cells to the nigro-striatal dopaminergic structures NEUROTOXICOLOGY
Artículo2014 Stress and inflammation: a detrimental combination in the development of neurodegenerative disease Inflammation and Cell Signaling
Artículo2013 Immunohistochemical detection of microglia HOST-PATHOGEN INTERACTIONS: METHODS AND PROTOCOLS
Artículo2013 Intracranial Injection of LPS in Rat as Animal Model of Neuroinflammation HOST-PATHOGEN INTERACTIONS: METHODS AND PROTOCOLS
Artículo2013 Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Artículo2012 Peripheral inflammation increases the deleterious effect of CNS inflammation on the nigrostriatal dopaminergic system NEUROTOXICOLOGY
Artículo2011 Inflammatory animal models for parkinson's disease: the intranigral injection of LPS induced the inflammatory process along with the selective degeneration of nigrostriatal dopaminergic neurons ISRN Neurology
Revisión2011 Peripheral Inflammation Increases the Damage in Animal Models of Nigrostriatal Dopaminergic Neurodegeneration: Possible Implication in Parkinson's Disease Incidence PARKINSONS DISEASE
Artículo2011 Stress is critical for LPS-induced activation of microglia and damage in the rat hippocampus NEUROBIOLOGY OF AGING
Artículo2010 Degeneration of dopaminergic neurons induced by thrombin injection in the substantia nigra of the rat is enhanced by dexamethasone: Role of monoamine oxidase enzyme NEUROTOXICOLOGY
Revisión2010 Proaging effects of stress: a review APPROACHES TO AGING CONTROL
Artículo2010 Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson's disease JOURNAL OF NEUROCHEMISTRY
Artículo2009 The intranigral injection of tissue plasminogen activator induced blood-brain barrier disruption, inflammatory process and degeneration of the dopaminergic system of the rat NEUROTOXICOLOGY
Artículo2008 Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production NEUROTOXICOLOGY
Artículo2008 Simvastatin prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide JOURNAL OF NEUROCHEMISTRY
Artículo2008 The intrastriatal injection of thrombin in rat induced a retrograde apoptotic degeneration of nigral dopaminergic neurons through synaptic elimination JOURNAL OF NEUROCHEMISTRY
Ponencia2007 Dexamethasone increases the neurotoxic effect of thrombin injection in the substantia nigra of the rat JOURNAL OF NEUROCHEMISTRY
Ponencia2007 Simvastatin prevent the inflammatory process and dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide JOURNAL OF NEUROCHEMISTRY
Artículo2006 Stress increases vulnerability to inflammation in the rat prefrontal cortex JOURNAL OF NEUROSCIENCE
Artículo2005 Blood-brain barrier disruption highly induces aquaporin-4 mRNA and protein in perivascular and parenchymal astrocytes: Protective effect by estradiol treatment in ovariectomized animals JOURNAL OF NEUROSCIENCE RESEARCH
Artículo2005 Deprenyl enhances the striatal neuronal damage produced by quinolinic acid MOLECULAR BRAIN RESEARCH
Artículo2004 Dopamine-dependent neurotoxicity of lipopolysaccharide in substantia nigra FASEB JOURNAL
Artículo2004 In vivo expression of aquaporin-4 by reactive microglia JOURNAL OF NEUROCHEMISTRY
Artículo2004 Minocycline reduces the lipopolysaccharide-induced inflammatory reaction, peroxynitrite-mediated nitration of proteins, disruption of the blood-brain barrier, and damage in the nigral dopaminergic system NEUROBIOLOGY OF DISEASE
Artículo2003 Thrombin induces in vivo degeneration of nigral dopaminergic neurones along with the activation of microglia JOURNAL OF NEUROCHEMISTRY

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/03/2006 28/02/2009 Investigador/a La enfermedad de Parkinson: Diagnostico en estado subclinico (EXC/2005/CTS-1014) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
01/09/2022 31/08/2025 Responsable Descifrando los subtipos de microglia deletérea potencialmente relevantes en enfermedades neurodegenerativas (PID2021-124096OB-I00) Ministerio de Ciencia e Innovación (Nacional)
01/01/2011 31/12/2013 Investigador/a Significado Biológico de la Integración de los distintos Mecanismos de Regulación del Factor de Elongación-2 en Condiciones de Estrés Celular y Envejecimiento (BFU2010-20882) Ministerio de Ciencia e Innovación (Nacional)
01/01/2016 31/12/2018 Responsable Funciones Apoptóticas y no Apoptóticas de las Caspasas Asesinas en el Sistema Nervioso Central en Condiciones Normales y Patológicas (SAF2015-64171-R) Ministerio de Economía y Competitividad (Nacional)
01/02/2020 30/04/2022 Investigador/a Study of the caspase-3 dependent mechanisms governing microglial activation in Parkinson's disease (US-1265062) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
01/01/2020 31/12/2022 Responsable Modulación de la activación microglial asociada a neurodegeneración, relevancia en enfermedades neurodegenerativas (P18-RT-1372) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
03/03/2011 03/03/2015 Investigador/a Estudio de los Cambios que Experimentan con el Envejecimiento las Rutas que Promueven la Supervivencia Celular y la Inflamación Cerebral: Modulación de las Mismas para Conseguir un Envejecimiento Saludable y Minimizar la Neurodegeneración (P09-CTS-5244) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/01/2019 31/12/2021 Responsable Papel de la Galectina-3 en la Respuesta Inmune Asociada a Enfermedades del Sistema Nervioso Central. Implicación en Enfermedades Neurodegenerativas y Glioblastoma Multiforme (RTI2018-098645-B-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
01/02/2020 30/04/2022 Responsable Papel de la Galectina -3 en el Envejecimiento Cerebral (US-1264806) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
15/03/2011 30/04/2016 Investigador/a Estudio de los Mecanismos Moleculares que Regulan la Inflamación Cerebral y la Longevidad. Diseño de Estrategias Farmacológicas Encaminadas a Minimizar el Daño Neuronal Asociado a la Inflamación Cerebral en Modelos Animales de Enfermedades Neurodegenerativas (P10-CTS-6494) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/10/2007 04/10/2011 Investigador/a Estudio del proceso de eliminación de sinapsis: implicación en enfermedades degenerativas, Parkinson y Alzheimer (SAF2007-62425) Ministerio de Educación y Ciencia (Nacional)
15/11/2003 15/11/2006 Investigador/a Estudio de posibles mecanismos celulares de muerte celular en la enfermedad de Parkinson, búsqueda de terapias neuroprotectoras del sistema dopaminérgico nigro-estriado (SAF2003-01996) Ministerio de Ciencia y Tecnología (Nacional)
11/01/2022 10/01/2024 Investigador/a Gb-Ap2 a Novel Blood-to-Brain Innumotherapy for Breast Cancer Brain Metastases (METAPREMIO 21) Asociación Española del Cáncer de Mama Metastásico (Nacional)
01/03/2006 28/02/2009 Contratado La enfermedad de Parkinson: Diagnostico en estado subclinico (EXC/2005/CTS-1014) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
El investigador no tiene ningún resultado de investigación asociado