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Ver Investigador - - Prisma - Unidad de Bibliometría

Jesus Angulo Alvarez

Beatriz Galindo (Investigador distinguido)
jangulo@us.es

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Líneas de investigación
Resumen
Tipo Año Título Fuente
Artículo2025 α-GalCer sp2-iminoglycolipid analogs as CD1d-dependent iNKT modulators: Evaluation of their immunotherapeutic potential in murine models of asthma and autoimmune hepatitis EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2024 Speeding-up the Determination of Protein-Ligand Affinities by STD NMR: The Reduced Data Set STD NMR Approach (rd-STD NMR) ANALYTICAL CHEMISTRY
Artículo2023 Fluorinated Man9 as a High Mannose Mimetic to Unravel Its Recognition by DC-SIGN Using NMR JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo2022 Inter-Ligand STD NMR: an efficient 1D NMR approach to probe relative orientation of ligands in a multi-subsite protein binding pocket PHARMACEUTICALS
Editorial2022 Prof. Jesús Jiménez-Barbero: Disentangling Molecular Recognition of Carbohydrates CURRENT MEDICINAL CHEMISTRY
Artículo2021 Chemoenzymatic Synthesis of Fluorinated Cellodextrins Identifies a New Allomorph for Cellulose-Like Materials** CHEMISTRY-A EUROPEAN JOURNAL
Artículo2021 Fucosidases from the human gut symbiont Ruminococcus gnavus CELLULAR AND MOLECULAR LIFE SCIENCES
Artículo2021 Fucosyltransferase-specific inhibitionvianext generation of fucose mimetics CHEMICAL COMMUNICATIONS
Artículo2021 FUT8-directed core fucosylation of N-glycans is regulated by the glycan structure and protein environment ACS CATALYSIS
Artículo2021 Molecular recognition of natural and non-natural substrates by cellodextrin phosphorylase from Ruminiclostridium thermocellum investigated by NMR spectroscopy. CHEMISTRY-A EUROPEAN JOURNAL
Artículo2021 Multifrequency STD NMR unveils the Interactions of antibiotics with Burkholderia multivorans biofilm exopolysaccharide FRONTIERS IN MOLECULAR BIOSCIENCES
Artículo2021 NleB/SseK-catalyzed arginine-glycosylation and enteropathogen virulence are finely tuned by a single variable position contiguous to the catalytic machinery CHEMICAL SCIENCE
Artículo2021 Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2021 Spin diffusion transfer difference (SDTD) NMR: an advanced method for the characterisation of water structuration within particle networks JOURNAL OF COLLOID AND INTERFACE SCIENCE
Artículo2021 Structural basis of trehalose recognition by the mycobacterial LpqY-SugABC transporter JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2021 The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract PLoS Biology
Artículo2020 Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B CHEMISTRY-A EUROPEAN JOURNAL
Artículo2020 Hydrophobization of Cellulose Nanocrystals for Aqueous Colloidal Suspensions and Gels BIOMACROMOLECULES
Artículo2020 Multifunctional nanoassemblies target bacterial lipopolysaccharides for enhanced antimicrobial DNA delivery COLLOIDS AND SURFACES B-BIOINTERFACES
Artículo2020 Saturation transfer difference NMR on the integral trimeric membrane transport protein GltPh determines cooperative substrate binding Scientific reports
Artículo2020 Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2019 Bug off Pain: An Educational Virtual Reality Game on Spider Venoms and Chronic Pain for Public Engagement JOURNAL OF CHEMICAL EDUCATION
Artículo2019 Deriving Ligand Orientation in Weak Protein-Ligand Complexes by DEEP-STD NMR Spectroscopy in the Absence of Protein Chemical-Shift Assignment CHEMBIOCHEM
Artículo2019 Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut NATURE MICROBIOLOGY
Artículo2019 Ginsenosides Act As Positive Modulators of P2X4 Receptors MOLECULAR PHARMACOLOGY
Artículo2019 Identification of selective protein-protein interaction inhibitors using efficient in silico peptide-directed ligand design CHEMICAL SCIENCE
Corrección2019 Identification of selective protein-protein interaction inhibitors using efficient in silico peptide-directed ligand design (vol 10, pg 4502, 2019) CHEMICAL SCIENCE
Artículo2019 Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7 Scientific reports
Artículo2019 Self-Correcting Method for the Measurement of Free Calcium and Magnesium Concentrations by H-1 NMR ANALYTICAL CHEMISTRY
Artículo2019 Serine-rich repeat protein adhesins from Lactobacillus reuteri display strain specific glycosylation profiles GLYCOBIOLOGY
Artículo2019 Spatially Resolved STD-NMR Applied to the Study of Solute Transport in Biphasic Systems: Application to Protein-Ligand Interactions NATURAL PRODUCT COMMUNICATIONS
Revisión2019 STD NMR as a Technique for Ligand Screening and Structural Studies BIOLOGICAL NMR, PT B
Artículo2019 Structural Basis of Glycerophosphodiester Recognition by the Mycobacterium tuberculosis Substrate-Binding Protein UgpB ACS CHEMICAL BIOLOGY
Artículo2019 Thermosensitive supramolecular and colloidal hydrogels via self-assembly modulated by hydrophobized cellulose nanocrystals CELLULOSE
Artículo2019 Tunable Supramolecular Gel Properties by Varying Thermal History CHEMISTRY-A EUROPEAN JOURNAL
Artículo2019 Understanding heat driven gelation of anionic cellulose nanofibrils: Combining saturation transfer difference (STD) NMR, small angle X-ray scattering (SAXS) and rheology JOURNAL OF COLLOID AND INTERFACE SCIENCE
Artículo2019 Unravelling the Specificity of Laminaribiose Phosphorylase from Paenibacillus sp. YM-1 towards Donor Substrates Glucose/Mannose 1-Phosphate by Using X-ray Crystallography and Saturation Transfer Difference NMR Spectroscopy CHEMBIOCHEM
Artículo2018 Discovery of Small Molecule WWP2 Ubiquitin Ligase Inhibitors CHEMISTRY-A EUROPEAN JOURNAL
Artículo2018 Mechanically Robust Gels Formed from Hydrophobized Cellulose Nanocrystals ACS APPLIED MATERIALS & INTERFACES
Artículo2018 Structural basis for arginine glycosylation of host substrates by bacterial effector proteins NATURE COMMUNICATIONS
Artículo2018 Structural basis for the role of serine- rich repeat proteins from Lactobacillus reuteri in gut microbe-host interactions PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo2018 Surfactant controlled zwitterionic cellulose nanofibril dispersions SOFT MATTER
Artículo2017 Cytotoxicity of Pyrazine-Based Cyclometalated (C boolean AND N-PZ boolean AND C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties INORGANIC CHEMISTRY
Artículo2017 Differential Epitope Mapping by STD NMR Spectroscopy To Reveal the Nature of Protein-Ligand Contacts ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Artículo2017 Supramolecular Amino Acid Based Hydrogels: Probing the Contribution of Additive Molecules using NMR Spectroscopy CHEMISTRY-A EUROPEAN JOURNAL
Artículo2017 Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus NATURE COMMUNICATIONS
Artículo2016 Detection and quantitative analysis of two independent binding modes of a small ligand responsible for DC-SIGN clustering ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2016 Spin Saturation Transfer Difference NMR (SSTD NMR): A New Tool to Obtain Kinetic Parameters of Chemical Exchange Processes JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
Artículo2016 Substituent interference on supramolecular assembly in urea gelators: synthesis, structure prediction and NMR SOFT MATTER
Corrección2016 Substituent interference on supramolecular assembly in urea gelators: synthesis, structure prediction and NMR (vol 12, pg 4034, 2016) SOFT MATTER
Artículo2016 Unveiling the "Three-Finger Pharmacophore" Required for p53-MDM2 Inhibition by Saturation-Transfer Difference (STD) NMR Initial Growth-Rates Approach CHEMISTRY-A EUROPEAN JOURNAL
Artículo2015 Assembling different antennas of the gp120 high mannose-type glycans on gold nanoparticles provides superior binding to the anti-HIV antibody 2G12 than the individual antennas CARBOHYDRATE RESEARCH
Artículo2015 Kinetics of intramolecular chemical exchange by initial growth rates of spin saturation transfer difference experiments (SSTD NMR) CHEMICAL COMMUNICATIONS
Artículo2015 Langerin-Heparin Interaction: Two Binding Sites for Small and Large Ligands As Revealed by a Combination of NMR Spectroscopy and Cross-Linking Mapping Experiments JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Capítulo2015 NMR Techniques for the Study of Transient Intermolecular Interactions STRUCTURE ELUCIDATION IN ORGANIC CHEMISTRY: THE SEARCH FOR THE RIGHT TOOLS
Artículo2015 Structures of glycans bound to receptors from saturation transfer difference (STD) NMR spectroscopy: Quantitative analysis by using CORCEMA-ST HOST-PATHOGEN INTERACTIONS: METHODS AND PROTOCOLS
Artículo2014 A STD-NMR Study of the Interaction of the Anabaena Ferredoxin-NADP(+) Reductase with the Coenzyme MOLECULES
Artículo2014 Importance of the polarity of the glycosaminoglycan chain on the interaction with FGF-1 GLYCOBIOLOGY
Ponencia2014 New approaches to the synthesis of hyaluronic acid and chondroitin sulfate oligosaccharides XI Carbohydrate Symposium
Ponencia2014 NMR conformational analysis of glycosylated iminosugars inhibitors of barley β-amylase XI Carbohydrate Symposium
Artículo2014 The binding of TIA-1 to RNA C-rich sequences is driven by its C-terminal RRM domain RNA BIOLOGY
Artículo2013 3D structure of a heparin mimetic analogue of a FGF-1 activator. A NMR and molecular modelling study ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2013 Conformations of the iduronate ring in short heparin fragments described by time-averaged distance restrained molecular dynamics GLYCOBIOLOGY
Artículo2013 Insights into the Glycosaminoglycan-Mediated Cytotoxic Mechanism of Eosinophil Cationic Protein Revealed by NMR ACS CHEMICAL BIOLOGY
Artículo2013 NMR studies on carbohydrate interactions with DC-SIGN towards a quantitative STD analysis PURE AND APPLIED CHEMISTRY
Artículo2013 Selective Targeting of Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin (DC-SIGN) with Mannose-Based Glycomimetics: Synthesis and Interaction Studies of Bis(benzylamide) Derivatives of a Pseudomannobioside CHEMISTRY-A EUROPEAN JOURNAL
Artículo2013 Structure of a Glycomimetic Ligand in the Carbohydrate Recognition Domain of C-type Lectin DC-SIGN. Structural Requirements for Selectivity and Ligand Design JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo2013 Synthesis of chondroitin/dermatan sulfate-like oligosaccharides and evaluation of their protein affinity by fluorescence polarization ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2013 Synthesis, Biological Evaluation, WAC and NMR Studies of S-Galactosides and Non-Carbohydrate Ligands of Cholera Toxin Based on Polyhydroxyalkylfuroate Moieties CHEMISTRY-A EUROPEAN JOURNAL
Artículo2012 Effect of the Substituents of the Neighboring Ring in the Conformational Equilibrium of Iduronate in Heparin-like Trisaccharides CHEMISTRY-A EUROPEAN JOURNAL
Artículo2012 sp2-Iminosugar O-, S-, and N-Glycosides as Conformational Mimics of a-Linked Disaccharides; Implications for Glycosidase Inhibition CHEMISTRY-A EUROPEAN JOURNAL
Artículo2012 STD NMR Study of the Interactions between Antibody 2G12 and Synthetic Oligomannosides that Mimic Selected Branches of gp120 Glycans CHEMBIOCHEM
Artículo2012 Synthesis of amine-functionalized heparin oligosaccharides for the investigation of carbohydrate-protein interactions in microtiter plates ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2011 A Solution NMR Study of the Interactions of Oligomannosides and the Anti-HIV-1 2G12 Antibody Reveals Distinct Binding Modes for Branched Ligands CHEMISTRY-A EUROPEAN JOURNAL
Artículo2011 Espectroscopía RMN de Diferencia de Transferencia de Saturación (STD NMR). Aplicaciones en Química del Reconocimiento Molecular Anales de la Real Sociedad Española de Química
Artículo2011 Gold Nanoparticles Coated with Oligomannosides of HIV-1 Glycoprotein gp120 Mimic the Carbohydrate Epitope of Antibody 2G12 JOURNAL OF MOLECULAR BIOLOGY
Artículo2011 Insights into molecular recognition of Lewis(X) mimics by DC-SIGN using NMR and molecular modelling ORGANIC & BIOMOLECULAR CHEMISTRY
Revisión2011 STD-NMR: application to transient interactions between biomolecules-a quantitative approach EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Artículo2010 Ligand-Receptor Binding Affinities from Saturation Transfer Difference (STD) NMR Spectroscopy: The Binding Isotherm of STD Initial Growth Rates CHEMISTRY-A EUROPEAN JOURNAL
Artículo2008 Carbohydrate-carbohydrate interaction prominence in 3D supramolecular self-assembly JOURNAL OF PHYSICAL CHEMISTRY B
Artículo2008 Saturation Transfer Difference (STD) NMR Spectroscopy Characterization of Dual Binding Mode of a Mannose Disaccharide to DC-SIGN CHEMBIOCHEM
Artículo2006 Backbone dynamics of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue, by N-15 NMR relaxation methods Journal of Biomolecular NMR
Artículo2006 Blood group B galactosyltransferase: Insights into substrate binding from NMR experiments JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo2006 Fragment-based screening of the donor substrate specificity of human blood group B galactosyltransferase using saturation transfer difference NMR JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2006 NMR analysis of carbohydrate-protein interactions GLYCOMICS
Artículo2006 Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue FEBS JOURNAL
Artículo2005 Conformational flexibility of a synthetic glycosylaminoglycan bound to a fibroblast growth factor. FGF-1 recognizes both the C-1(4) and S-2(0) conformations of a bioactive heparin-like hexasaccharide JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo2005 Dynamic properties of biologically active synthetic heparin-like hexasaccharides GLYCOBIOLOGY
Artículo2005 Neutralization of a common cold virus by concatemers of the third ligand binding module of the VLDL-receptor strongly depends on the number of modules Virology
Artículo2005 The conformational behaviour of alpha,beta-trehalose-like disaccharides and their C-glycosyl, imino-C-glycosyl and carbagalactose analogues depends on the chemical nature of the modification: an NMR investigation TETRAHEDRON-ASYMMETRY
Artículo2004 The activation of fibroblast growth factors (FGFs) by glycosaminoglycans: Influence of the sulfation pattern on the biological activity of FGF-1 CHEMBIOCHEM
Artículo2004 The heparin-Ca2+ interaction: the influence of the O-sulfation pattern on binding CARBOHYDRATE RESEARCH
Artículo2003 A molecular dynamics description of the conformational flexibility of the L-iduronate ring in glycosaminoglycans CHEMICAL COMMUNICATIONS
Artículo2003 Synthesis and structural study of two new heparin-like hexasaccharides ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2002 The activation of fibroblast growth factors by heparin: Synthesis and structural study of rationally modified heparin-like oligosaccharides CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE
Artículo2002 The heparin-Ca2+ interaction: Structure of the Ca2+ binding site EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2001 The activation of fibroblast growth factors by heparin: Synthesis, structure, and biological activity of heparin-like oligosaccharides CHEMBIOCHEM
Artículo2000 Interaction of heparin with Ca(2+): A model study with a synthetic heparin-like hexasaccharide ISRAEL JOURNAL OF CHEMISTRY
Artículo2000 The solution conformation of glycosyl inositols related to inositolphosphoglycan (IPG) mediators TETRAHEDRON-ASYMMETRY
Estudio de la estructura tridimensional y de la dinámica de oligosacáridos modelos de glicosaminoglicanos mediante RMN y simulaciones de dinámica molecular (2002)
Dirigida por: Nieto Mesa, Pedro Manuel
Tesis dirigidas/tutorizadas:3
Fecha lectura Título Rol
25/10/2013 INSIGHTS ON THE STRUCTURE AND DYNAMICS OF GLYCOSAMINOGLYCANS AND THEIR INTERACTIONS WITH LANGERING:NMR AND COMPUTATIONAL STUDIES Director/a
18/03/2013 GLYCOMIMETIC LIGANDS OF DC-SIGN: STRUCTURAL INSIGHTS INTO THEIR MOLECULAR RECOGNITION BY NMR AND COMPUTATIONAL TECHNIQUES Director/a
23/03/2011 INTERACCIONES DE OLIGOMANOSIDOS CON EL ANTICUERPO 2G12 (ANTI VIH-1), ESTUDIOS POR RMN Y MODELIZACIÓN MOLECULAR Director/a

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/06/2020 31/05/2023 Responsable Nuevas Herramientas Std NMR para Obtener Estructuras 3d de Complejos Proteína-Ligando Débiles: Aplicación a Interacciones Proteína carbohidrato Biológicamente Relevantes (PID2019-109395GB-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
01/01/2022 31/12/2022 Investigador/a Reconocimiento cruzado de glicosidasas y lectinas: Mecanismos y oportunidades en el desarrollo de fármacos multidiana (US-1380698) Consejería de Economía, Conocimiento, Empresas y Universidad (Autonómico)
05/10/2021 31/03/2023 Investigador/a A 19F-protein and 1H-Ligand NMR toolkit to design inhibitors of bacterial virulence effectors (P20_01176) Junta de Andalucía (Consejería de Economía, Conocimiento, Empresas y Universidad) (Autonómico)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2020 31/12/2020 Responsable Ayudas para el uso de los Servicios Generales de Investigación (PPI506/2020) Universidad de Sevilla (Local)
El investigador no tiene ningún resultado de investigación asociado