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PlasticityDisease - Prisma - Unidad de Bibliometría

Plasticidad celular y enfermedades - BIO-377 (PlasticityDisease)

Tipo de colectivo: Grupo de investigación
Estado: Grupo definitivo
Ámbito: Andalucía
Instituciones: Universidad de Sevilla
Fecha de creación: 25/02/2025

Investiga en

Palabras clave
Líneas de investigación
Resumen
Nombre Rol
Comaills, Valentine Rosine Investigadora principal
Dorronsoro Gonzalez, Akaitz Miembro
Lopez Noriega, Livia Del Rocio Miembro
Mendoza Leon, Francisco Javier Miembro
Tipo Año Título Fuente
Corrección2025 Author Correction: Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging COMMUNICATIONS BIOLOGY
Artículo2025 Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell function iScience
Artículo2024 Enhancing human islet xenotransplant survival and function in diabetic immunocompetent mice through LRH-1/NR5A2 pharmacological activation FRONTIERS IN IMMUNOLOGY
Artículo2024 LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype Clinical and translational medicine
Artículo2023 Chromosomal Instability in Genome Evolution: From Cancer to Macroevolution Biology
Artículo2023 Enzyme-responsive Zr-based metal-organic frameworks for controlled drug delivery: taking advantage of clickable PEG-phosphate ligands. ACS APPLIED MATERIALS & INTERFACES
Artículo2023 Identification of biomarkers for glycaemic deterioration in type 2 diabetes NATURE COMMUNICATIONS
Capítulo2023 Innovación docente en las prácticas de laboratorio de genética: clase invertida y pensamiento crítico Educación, tecnología, innovación y transferencia del conocimiento
Resumen congreso2023 Leader beta cells within the pancreatic islets are a functionally stable subpopulation in vitro and in vivo DIABETOLOGIA
Artículo2023 Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging COMMUNICATIONS BIOLOGY
Artículo2023 Molecular phenotyping of single pancreatic islet leader beta cells by "Flash-Seq" LIFE SCIENCES
Revisión2023 The PTGS2/COX2-PGE2 signaling cascade in inflammation: Pro or anti? A case study with type 1 diabetes mellitus International Journal of Biological Sciences
Artículo2022 Defects in Long-Term APC Repopulation Ability of Adult Human Bone Marrow Hematopoietic Stem Cells (HSCs) Compared with Fetal Liver HSCs JOURNAL OF IMMUNOLOGY
Artículo2022 Differential Kinase Activity Across Prostate Tumor Compartments Defines Sensitivity to Target Inhibition CANCER RESEARCH
Resumen congreso2022 LRH-1/NR5A2 Agonism Triggers an Anti-Inflammatory Phenotypic Switch of Immune Cells from Patients with Type 1 Diabetes and Improves Islet Engraftment/Function DIABETES
Artículo2022 MicroRNA-4732-3p Is Dysregulated in Breast Cancer Patients with Cardiotoxicity, and Its Therapeutic Delivery Protects the Heart from Doxorubicin-Induced Oxidative Stress in Rats ANTIOXIDANTS
Artículo2022 Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion DIABETES
Artículo2022 NR5A2/LRH-1 regulates the PTGS2-PGE2-PTGER1 pathway contributing to pancreatic islet survival and function iScience
Artículo2022 Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase DIABETOLOGIA
Revisión2022 Physical Forces and Transient Nuclear Envelope Rupture during Metastasis: The Key for Success? CANCERS
Corrección2022 Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation (vol 2020, 8872009, 2020) Stem Cells International
Revisión2022 Roles of extracellular vesicles associated non-coding RNAs in Diabetes Mellitus Frontiers in Endocrinology
Artículo2022 Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney DIABETES
Artículo2022 Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice Frontiers in Endocrinology
Revisión2021 Harnessing the Endogenous Plasticity of Pancreatic Islets: A Feasible Regenerative Medicine Therapy for Diabetes? INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2021 HIF-1α and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2021 HIF-Overexpression and Pro-Inflammatory Priming in Human Mesenchymal Stromal Cells Improves the Healing Properties of Extracellular Vesicles in Experimental Crohn's Disease INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2021 Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice NATURE COMMUNICATIONS
Corrección2021 Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice (vol 12, 5165, 2021) NATURE COMMUNICATIONS
Revisión2021 Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function Frontiers in Endocrinology
Artículo2021 Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging AGING CELL
Artículo2021 miR-4732-3p in Extracellular Vesicles From Mesenchymal Stromal Cells Is Cardioprotective During Myocardial Ischemia FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Resumen congreso2021 Novel biomarkers for glycaemic deterioration in type 2 diabetes: an IMI RHAPSODY study DIABETOLOGIA
Artículo2021 NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer MOLECULAR CELL
Revisión2021 Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Resumen congreso2021 SGLT2 contributes to glucoregulatory improvements following vertical sleeve gastrectomy in mice DIABETOLOGIA
Artículo2021 The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity THERANOSTICS
Resumen congreso2020 Bariatric Surgery Downregulates Glucocorticoid Signaling in Mice DIABETES
Resumen congreso2020 Bariatric Surgery Improves Ca2+Dynamics across Pancreatic Islets In Vivo DIABETES
Artículo2020 Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis SCIENCE
Artículo2020 Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation Scientific reports
Resumen congreso2020 Metabolic surgery inhibits sodium glucose co-transporter 2 (SGLT2) expression in the kidney of lean mice Diabetic Medicine
Resumen congreso2020 Metabolic surgery recovers Ca2+dynamics across pancreatic islets in obese mice DIABETOLOGIA
Artículo2020 Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation Stem Cells International
Resumen congreso2020 The long non-coding RNA PAX6-AS1 modulates human beta cell function Diabetic Medicine
Artículo2020 The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice DIABETOLOGIA
Artículo2019 A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells ONCOGENE
Resumen congreso2019 Cardioprotective effect of miRNAs derived from mesenchymal stem cells extracellular vesicles in doxorubicin-induced damage HUMAN GENE THERAPY
Artículo2019 COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Resumen congreso2019 Extracellular vesicles with enhanced immunosuppression capacity secreted by genetically improved mesenchymal stem cells derived from dental pulp HUMAN GENE THERAPY
Artículo2019 Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging AGING-US
Resumen congreso2019 Inhibition of Kidney SGLT2 Expression following Bariatric Surgery in Mice DIABETES
Artículo2019 SETD1A protects from senescence through regulation of the mitotic gene expression program NATURE COMMUNICATIONS
Resumen congreso2019 The long non-coding RNA PAX6-AS1 controls human beta cell identity DIABETOLOGIA
Artículo2019 Transient PAX8 Expression in Islets During Pregnancy Correlates With β-Cell Survival, Revealing a Novel Candidate Gene in Gestational Diabetes Mellitus DIABETES
Artículo2018 AR Expression in Breast Cancer CTCs Associates with Bone Metastases MOLECULAR CANCER RESEARCH
Artículo2018 Extracellular Vesicles Secreted by Hypoxic AC10 Cardiomyocytes Modulate Fibroblast Cell Motility FRONTIERS IN CARDIOVASCULAR MEDICINE
Artículo2018 LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus NATURE COMMUNICATIONS
Artículo2018 The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity CELL DEATH & DISEASE
Artículo2017 ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells GENES & DEVELOPMENT
Resumen congreso2017 Characterisation of iPSCs from a patient with transposition of the great arteries HUMAN GENE THERAPY
Artículo2017 Characterization of a Fetal Liver Cell Population Endowed with Long-Term Multiorgan Endothelial Reconstitution Potential STEM CELLS
Artículo2017 Expression of beta-globin by cancer cells promotes cell survival during blood-borne dissemination NATURE COMMUNICATIONS
Artículo2017 Identification of HSP90 inhibitors as a novel class of senolytics NATURE COMMUNICATIONS
Artículo2017 IFNγ Regulates Activated Vδ2+T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells PLOS ONE
Artículo2017 Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice PLOS ONE
Artículo2017 Levothyroxine enhances glucose clearance and blunts the onset of experimental type 1 diabetes mellitus in mice BRITISH JOURNAL OF PHARMACOLOGY
Resumen congreso2017 Pax8, a prosurvival gene in islets potentially implicated in gestational diabetes DIABETOLOGIA
Artículo2017 Quantitative Analysis of Cellular Senescence in Culture and In Vivo. Current protocols in cytometry
Revisión2017 Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors EXPERT OPINION ON THERAPEUTIC TARGETS
Resumen congreso2017 The combination of cell and gene therapy as new generation tool to boost MSCs immunosuppressive and tissue regeneration properties HUMAN GENE THERAPY
Artículo2016 Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition CELL REPORTS
Artículo2016 PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus DIABETOLOGIA
Artículo2016 Podocalyxin-like protein 1 is a relevant marker for human c-kitpos cardiac stem cells JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Revisión2016 Regulation of chronic inflammatory and immune processes by extracellular vesicles JOURNAL OF CLINICAL INVESTIGATION
Artículo2015 A Simple High Efficiency Intra-Islet Transduction Protocol Using Lentiviral Vectors CURRENT GENE THERAPY
Artículo2015 PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet Scientific reports
Artículo2015 SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes NATURE COMMUNICATIONS
Artículo2015 The Achilles' heel of senescent cells: from transcriptome to senolytic drugs AGING CELL
Artículo2015 The role of Pax8 in Pancreatic Islet Physiology Biosaia
Artículo2014 Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility SCIENCE
Artículo2014 Human mesenchymal stromal cells modulate T-cell responses through TNF-α-mediated activation of NF-κψB European Journal Of Immunology
Artículo2014 Sox2 promotes tamoxifen resistance in breast cancer cells EMBO Molecular Medicine
Artículo2014 The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation CELL DEATH & DISEASE
Corrección2014 The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation (vol 5, e1399, 2014) CELL DEATH & DISEASE
Capítulo2013 C-jun-centred regulatory network of signalling pathways in bone stem cells and applications to bone repair Stem Cells and Bone Tissue
Revisión2013 Human Mesenchymal Stromal Cell-Mediated Immunoregulation: Mechanisms of Action and Clinical Applications BONE MARROW RESEARCH
Artículo2013 Hypoxia-Inducible Factor 1 Alpha Contributes to Cardiac Healing in Mesenchymal Stem Cells-Mediated Cardiac Repair Stem Cells and Development
Artículo2013 Identification of the NF-κB inhibitor A20 as a key regulator for human adipogenesis CELL DEATH & DISEASE
Editorial2013 Regenerating the injured kidney with human umbilical cord mesenchymal stem cell-derived exosomes Stem cell research & therapy
Resumen congreso2012 Histone deacetylase 3 modulates the expansion of human hematopoietic stem cells HUMAN GENE THERAPY
Artículo2012 Histone Deacetylase 3 Modulates the Expansion of Human Hematopoietic Stem Cells Stem Cells and Development
Artículo2012 Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo2012 IL1β Induces Mesenchymal Stem Cells Migration and Leucocyte Chemotaxis Through NF-κB STEM CELL REVIEWS AND REPORTS
Artículo2011 Effects of estrogen on the proportion of stem cells in the breast BREAST CANCER RESEARCH AND TREATMENT
Artículo2010 Regulation of Human Bone Marrow Stromal Cell Proliferation and Differentiation Capacity by Glucocorticoid Receptor and AP-1 Crosstalk JOURNAL OF BONE AND MINERAL RESEARCH
Resumen congreso2009 Study of the TNF-α Effects on MSC Proliferation, Differentation and Cytokine Secretion HUMAN GENE THERAPY

Proyectos de Investigación

Fecha de inicio Fecha de fin Denominación Agencia financiadora Importe concedido
01/12/2024 30/11/2027 Vesículas extracelulares derivadas de células mesenquimales estromales bioingenierizadas para el tratamiento de diabetes tipo 1. (SOL2024-31706) Universidad de Sevilla (Local) 196.201,25 €
01/09/2023 31/08/2026 Inestabilidad cromosómica durante la Transición-Epitelio-Mesénquima (PID2022-136786OA-I00) Ministerio de Ciencia e Innovación (Nacional) 231.250,00 €
El colectivo no tiene ningún resultado de investigación asociado