QUIMICA BIOORGANICA DE CARBOHI - Prisma - Unidad de Bibliometría

QUIMICA BIOORGANICA DE CARBOHIDRATOS - FQM-308 (QUIMICA BIOORGANICA DE CARBOHI)

Tipo de colectivo: Grupo de investigación
Estado: Grupo definitivo
Ámbito: Andalucía
Instituciones: Universidad de Sevilla
Fecha de creación: 01/01/1995

Investiga en

Tipo Año Título Fuente
Artículo2025 β-Cyclodextrin-based geometrically frustrated amphiphiles as one-component, cell-specific and organ-specific nucleic acid delivery systems CARBOHYDRATE POLYMERS
Capítulo2024 Exploración de la combinación de diferentes herramientas didácticas sobre el aprendizaje activo del alumnado Ciclos de mejora en el aula. Año 2022-23. Experiencias de innovación docente de la Universidad de Sevilla
Artículo2024 Extending the Scope of the C-Functionalization of Cyclam via Copper(I)-Catalyzed Alkyne-Azide Cycloaddition to Bifunctional Chelators of Interest JOURNAL OF ORGANIC CHEMISTRY
Artículo2024 High-Mannose Oligosaccharide Hemimimetics that Recapitulate the Conformation and Binding Mode to Concanavalin A, DC-SIGN and Langerin CHEMISTRY-A EUROPEAN JOURNAL
Artículo2024 Protocol for photo-controlling the assembly of cyclic peptide nanotubes in solution and inside microfluidic droplets STAR Protocols
Capítulo2024 Sinergias educativas en el ámbito de la química orgánica Enseñanza e innovación educativa en el ámbito universitario
Artículo2024 sp2-Iminosugar azobenzene O-glycosides: light-sensitive glycosidase inhibitors with unprecedented tunability and switching factors BIOORGANIC CHEMISTRY
Artículo2024 Speeding-up the Determination of Protein-Ligand Affinities by STD NMR: The Reduced Data Set STD NMR Approach (rd-STD NMR) ANALYTICAL CHEMISTRY
Artículo2024 Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity. JOURNAL OF MATERIALS CHEMISTRY B
Artículo2023 A selenoureido-iminoglycolipid transported by zeolitic-imidazolate framework nanoparticles: a novel antioxidant therapeutic approach. NANOSCALE HORIZONS
Capítulo2023 Aula invertida: percepción del profesorado del papel desempeñado por los estudiantes en la práctica de laboratorio “separación por extracción” Mejorando la enseñanza a través de la innovación educativa
Capítulo2023 Exploración de la combinación de diferentes herramientasdidácticas sobre el aprendizaje activo del alumnado Ciclos de mejora en el aula. Curso 2022-23: experiencias de innovación docente de la Universidad de Sevilla
Artículo2023 Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Capítulo2023 La implicación del alumnado como fuerza motriz en el desarrollo de la asignatura Experimentación en Química II Ciclos de mejora en el aula. Curso 2022-23: experiencias de innovación docente de la Universidad de Sevilla
Artículo2023 Photo-assembling cyclic peptides for dynamic light-driven peptide nanotubes CHEM
Artículo2023 Potent and selective cell-active iminosugar inhibitors of human α-N-acetylgalactosaminidase (α-NAGAL) CHEMISTRY-A EUROPEAN JOURNAL
Artículo2023 Reversible light-induced dimerization of secondary face azobenzene-functionalized β-cyclodextrin derivatives JOURNAL OF ORGANIC CHEMISTRY
Artículo2023 Self-healing cyclic peptide hydrogels JOURNAL OF MATERIALS CHEMISTRY B
Artículo2023 Serine-/Cysteine-based sp2-Iminoglycolipids as novel TLR4 agonists: evaluation of their adjuvancy and immunotherapeutic properties in a murine model of asthma JOURNAL OF MEDICINAL CHEMISTRY
Ponencia2023 Sistemas de transporte de genes basados en ciclooligosacáridos policatiónicos con capacidad de respuesta al pH y al potencial redox XVI Congreso SEFIG ( 16. 2023. Madrid): Libro de comunicaciones
Artículo2023 Synthesis, biological evaluation, and docking studies of open-chain carbohydrate amides as acetylcholinesterase inhibitors. MEDICINAL CHEMISTRY
Artículo2022 A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Artículo2022 A beta-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells. PHARMACEUTICS
Artículo2022 Bicyclic picomolar OGA inhibitors enable chemoproteomic mapping of its endogenous post-translational modifications JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo2022 Bottom-up supramolecular assembly in two dimensions CHEMICAL SCIENCE
Capítulo2022 Cyclization and self-assembly of cyclic peptides Peptide macrocycles: methods and protocols
Artículo2022 Dynamic nanosurface reconfiguration by host-guest supramolecular interactions NANOSCALE
Artículo2022 Enhanced gene delivery triggered by dual pH/Redox responsive host-guest dimerization of cyclooligosaccharide star polycations. Macromolecular rapid communications
Artículo2022 Mannobioside biomimetics that trigger DC-SIGN binding selectivity. CHEMICAL COMMUNICATIONS
Artículo2022 sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Artículo2022 Stereoselective Synthesis of Nojirimycin α-C-Glycosides from a Bicyclic Acyliminium Intermediate: A Convenient Entry to N,C-Biantennary Glycomimetics ACS OMEGA
Artículo2022 Unravelling the Inflammatory Processes in the Early Stages of Diabetic Nephropathy and the Potential Effect of (S-s)-DS-ONJ INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2021 A versatile stereocontrolled synthesis of 2-deoxyiminosugarC-glycosides and their evaluation as glycosidase inhibitors ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2021 Anti-inflammatory (M2) response is induced by a sp(2)-iminosugar glycolipid sulfoxide in diabetic retinopathy FRONTIERS IN IMMUNOLOGY
Artículo2021 Loading Linear Arrays of Cu-II Inside Aromatic Amide Helices ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Artículo2021 Rational design of cell active C2-modified DGJ analogues for the inhibition of human alpha-galactosidase A (GALA) ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2021 Sensing a binding event through charge transport variations using an aromatic oligoamide capsule CHEMICAL SCIENCE
Artículo2021 Synthesis of sp(2)-iminosugar selenoglycolipids as multitarget drug candidates with antiproliferative, leishmanicidal and anti-inflammatory properties MOLECULES
Artículo2021 Synthesis, self-assembly and anticancer drug encapsulation and delivery properties of cyclodextrin-based giant amphiphiles CARBOHYDRATE POLYMERS
Otros2021 Técnicas básicas en un laboratorio de química orgánica: calentamiento a reflujo. Síntesis de acetanilida Portal de Vídeo Didáctico de la Universidad de Sevilla
Otros2021 Técnicas básicas en un laboratorio de química orgánica: cromatografía en capa fina. Portal de Vídeo Didáctico de la Universidad de Sevilla
Otros2021 Técnicas básicas en un laboratorio de química orgánica: cromatografía en columna de gel de sílice. Portal de Vídeo Didáctico de la Universidad de Sevilla
Otros2021 Técnicas básicas en un laboratorio de química orgánica: destilación simple. Portal de Vídeo Didáctico de la Universidad de Sevilla
Otros2021 Técnicas básicas en un laboratorio de química orgánica: recristalización Portal de Vídeo Didáctico de la Universidad de Sevilla
Otros2021 Técnicas básicas en un laboratorio de química orgánica: separación por extracción Portal de Vídeo Didáctico de la Universidad de Sevilla
Artículo2021 The emergence of order: A closer look at peptide assembly and its complexity Matter
Artículo2021 Trifaceted mickey mouse amphiphiles for programmable self-assembly, DNA complexation and organ-selective gene delivery. CHEMISTRY-A EUROPEAN JOURNAL
Artículo2020 Amplified Detection of Breast Cancer Autoantibodies Using MUC1-Based Tn Antigen Mimics JOURNAL OF MEDICINAL CHEMISTRY
Artículo2020 An Adhesive Peptide from the C-Terminal Domain of α-Synuclein for Single-Layer Adsorption of Nanoparticles onto Substrates BIOCONJUGATE CHEMISTRY
Artículo2020 Carbohydrate supramolecular chemistry: beyond the multivalent effect CHEMICAL COMMUNICATIONS
Artículo2020 Click synthesis of size- and shape-tunable star polymers with functional macrocyclic cores for synergistic DNA complexation and delivery BIOMACROMOLECULES
Revisión2020 Cyclodextrin-based functional glyconanomaterials NANOMATERIALS
Artículo2020 Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Capítulo2020 El liderazgo como herramienta útil del alumnado en su proceso de aprendizaje Ciclos de mejora en el aula. Año 2019. Experiencias de innovación docente de la Universidad de Sevilla
Artículo2020 Nanoparticle-delivered HIV peptides to dendritic cells a promising approach to generate a therapeutic vaccine PHARMACEUTICS
Artículo2020 Singlet oxygen stimulus for switchable functional organic cages CHEMICAL SCIENCE
Capítulo2020 sp2-Iminosugars as chemical mimics for glycodrug design Small molecule drug discovery: methods, molecules and applications
Artículo2020 Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Artículo2020 Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Bronsted Acid-Type Organocatalysis JOURNAL OF ORGANIC CHEMISTRY
Revisión2020 Synthesis and Supramolecular Functional Assemblies of Ratiometric pH Probes CHEMISTRY-A EUROPEAN JOURNAL
Artículo2020 Synthesis, conformational analysis and: In vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment CHEMICAL SCIENCE
Artículo2020 Tuning the Topological Landscape of DNA–Cyclodextrin Nanocomplexes by Molecular Design CHEMISTRY-A EUROPEAN JOURNAL
Artículo2019 Dynamic Control of the Self-Assembling Properties of Cyclodextrins by the Interplay of Aromatic and Host-Guest Interactions FRONTIERS IN CHEMISTRY
Artículo2019 Mannose-coated polydiacetylene (PDA)-based nanomicelles: synthesis, interaction with concanavalin A and application in the water solubilization and delivery of hydrophobic molecules JOURNAL OF MATERIALS CHEMISTRY B
Artículo2019 Multiply-linked cyclodextrin-aromatic hybrids: Caps, hinges and clips JOURNAL OF CARBOHYDRATE CHEMISTRY
Artículo2019 Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators CHEMICAL COMMUNICATIONS
Editorial2019 Novel Therapies for Orphan Diseases ACS MEDICINAL CHEMISTRY LETTERS
Artículo2019 Pharmacological Chaperones for the Treatment of alpha-Mannosidosis JOURNAL OF MEDICINAL CHEMISTRY
Resumen congreso2019 Screening sp(2)-iminosugar N-glycosides as pharmacological chaperone candidates for a mannosidosis: the effect of aglycone nature and valency MOLECULAR GENETICS AND METABOLISM
Artículo2019 sp(2)-Iminosugar glycolipids as inhibitors of lipopolysaccharide-mediated human dendritic cell activation in vitro and of acute inflammation in mice in vivo EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2019 Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2019 Tailoring the inhibitory versus chaperoning behavior of amphiphilic sp(2)-iminosugar glycomimetics targeting beta-glucocerebrosidase: From micromolar to picomolar chaperones for Gaucher disease MOLECULAR GENETICS AND METABOLISM
Artículo2019 Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp(2)-Iminosugar Glycolipids MOLECULES
Artículo2019 Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties CHEMICAL COMMUNICATIONS
Revisión2019 Where in the Cell Is our Cargo? Methods Currently Used To Study Intracellular Cytosolic Localisation CHEMBIOCHEM
Artículo2018 Catalyst-Free Synthesis of Alkylpolyglycosides Induced by High-Frequency Ultrasound CHEMSUSCHEM
Artículo2018 Giant Glycosidase Inhibitors: First- and Second-Generation Fullerodendrimers with a Dense Iminosugar Shell CHEMISTRY-A EUROPEAN JOURNAL
Artículo2018 Nuevas estrategias en el proceso de enseñanza-aprendizaje de la asignatura Experimentación Química II del Grado en Ingeniería Química Industrial Jornadas de Formación e Innovación Docente del Profesorado
Artículo2018 pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets NANOSCALE HORIZONS
Artículo2018 Plasmid-Templated Control of DNA-Cyclodextrin Nanoparticle Morphology through Molecular Vector Design for Effective Gene Delivery CHEMISTRY-A EUROPEAN JOURNAL
Artículo2018 Probing the Inhibitor versus Chaperone Properties of sp(2)-Iminosugars towards Human beta-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease MOLECULES
Artículo2018 Revealing cooperative binding of polycationic cyclodextrins with DNA oligomers by capillary electrophoresis coupled to mass spectrometry ANALYTICA CHIMICA ACTA
Artículo2018 The sp(2)-iminosugar glycolipid 1-dodecylsulfony1-5N,6O-oxomethylidenenojirimycin (DSO2-ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants FOOD AND CHEMICAL TOXICOLOGY
Artículo2018 Xylylene Clips for the Topology-Guided Control of the Inclusion and Self-Assembling Properties of Cyclodextrins JOURNAL OF ORGANIC CHEMISTRY
Resumen congreso2017 Inhibitors and effectors of the glycosidases as therapeutic tools Biosaia
Artículo2017 A novel potential nanophototherapeutic based on the assembly of an amphiphilic cationic beta-cyclodextrin and an anionic porphyrin JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
Artículo2017 Biophysics and protein corona analysis of Janus cyclodextrin-DNA nanocomplexes. Efficient cellular transfection on cancer cells BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Artículo2017 Carbon Dioxide as a Traceless Caramelization Promotor: Preparation of Prebiotic Difructose Dianhydrides (DFAs)-Enriched Caramels from D-Fructose JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2017 Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers JOURNAL OF MATERIALS CHEMISTRY B
Artículo2017 Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery BEILSTEIN JOURNAL OF NANOTECHNOLOGY
Artículo2017 Docetaxel-Loaded Nanoparticles Assembled from beta-Cyclodextrin/Calixarene Giant Surfactants: Physicochemical Properties and Cytotoxic Effect in Prostate Cancer and Glioblastoma Cells FRONTIERS IN PHARMACOLOGY
Artículo2017 Electrochemistry of Redox-Active Guest Molecules at beta-Cyclodextrin-Functionalized Silicon Electrodes ChemElectroChem
Artículo2017 Electron-Transfer Rates in Host Guest Assemblies at beta-Cyclodextrin Monolayers LANGMUIR
Artículo2017 Fluorinated Chaperone-beta-Cyclodextrin Formulations for beta-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease JOURNAL OF MEDICINAL CHEMISTRY
Ponencia2017 Fluorinated chaperone-beta-cyclodextrin formulations for neuronopathic Gaucher disease MOLECULAR GENETICS AND METABOLISM
Artículo2017 Molecular determinants for cyclooligosaccharide-based nanoparticle-mediated effective siRNA transfection NANOMEDICINE
Revisión2017 Molecular nanoparticle-based gene delivery systems JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Artículo2017 Molecular photoswitches mediating the strain-driven disassembly of supramolecular tubules PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo2017 Multi-dimensional charge transport in supramolecular helical foldamer assemblies CHEMICAL SCIENCE
Artículo2017 Multivalency as an action principle in multimodal lectin recognition and glycosidase inhibition: a paradigm shift driven by carbon-based glyconanomaterials JOURNAL OF MATERIALS CHEMISTRY B
Artículo2017 sp(2)-Iminosugar -glucosidase inhibitor 1-C-octyl-2-oxa-3-oxocastanospermine specifically affected breast cancer cell migration through Stim1, 1-integrin, and FAK signaling pathways JOURNAL OF CELLULAR PHYSIOLOGY
Artículo2017 Synthesis of beta-galactosylamides as ligands of the peanut lectin. Insights into the recognition process CARBOHYDRATE RESEARCH
Artículo2017 The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study CHEMISTRY-A EUROPEAN JOURNAL
Artículo2016 Cholesterol-Targeted Anticancer and Apoptotic Effects of Anionic and Polycationic Amphiphilic Cyclodextrin Nanoparticles JOURNAL OF PHARMACEUTICAL SCIENCES
Artículo2016 Conformationally-locked C-glycosides: tuning aglycone interactions for optimal chaperone behaviour in Gaucher fibroblasts ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2016 Cyclodextrin-based facial amphiphiles: assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2016 Deciphering of polycationic carbohydrate based non-viral gene delivery agents by ESI-LTQ-Orbitrap using CID/HCD pairwise tandem mass spectrometry RSC ADVANCES
Artículo2016 Dual drug-loaded halloysite hybrid-based glycocluster for sustained release of hydrophobic molecules RSC ADVANCES
Artículo2016 Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp(2)-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Corrección2016 Generalized Anomeric Effect in gem-Diamines: Stereoselective Synthesis of alpha-N-Linked Disaccharide Mimics (vol 11, pg 3306, 2009) ORGANIC LETTERS
Artículo2016 Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, G(M1)-gangliosidosis and Fabry diseases CHEMICAL COMMUNICATIONS
Artículo2016 Impact of Nonthermal Atmospheric Plasma on the Structure of Cellulose: Access to Soluble Branched Glucans CHEMISTRY-A EUROPEAN JOURNAL
Artículo2016 Influence of the configurational pattern of sp(2)-iminosugar pseudo N-, S-, O- and C-glycosides on their glycoside inhibitory and antitumor properties CARBOHYDRATE RESEARCH
Artículo2016 Inhibitor versus chaperone behaviour of D-fagomine, DAB and LAB sp2-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Ponencia2016 Modulation of microglia polarization dynamics by a sp2-iminosugar derivative during diabetic retinophaty in db/db mice EUROPEAN JOURNAL OF OPHTHALMOLOGY
Artículo2016 Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Ponencia2016 pH-responsive pharmacological chaperones for lysosomal disease MOLECULAR GENETICS AND METABOLISM
Artículo2016 Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition CHEMISTRY-A EUROPEAN JOURNAL
Artículo2016 Tn Antigen Mimics Based on sp(2)-Iminosugars with Affinity for an anti-MUC1 Antibody ORGANIC LETTERS
Artículo2016 Toward a suitable structural analysis of gene delivery carrier based on polycationic carbohydrates by electron transfer dissociation tandem mass spectrometry ANALYTICA CHIMICA ACTA
Artículo2016 Trehalose-based Janus cyclooligosaccharides: the "Click" synthesis and DNA-directed assembly into pH-sensitive transfectious nanoparticles CHEMICAL COMMUNICATIONS
Artículo2016 Tuning of glyconanomaterial shape and size for selective bacterial cell agglutination JOURNAL OF MATERIALS CHEMISTRY B
Artículo2016 Understanding multivalent effects in glycosidase inhibition using C-glycoside click clusters as molecular probes NEW JOURNAL OF CHEMISTRY
Artículo2015 Antileishmanial activity of sp(2)-iminosugar derivatives RSC ADVANCES
Artículo2015 Cell uptake mechanisms of glycosylated cationic pDNA-cyclodextrin nanoparticles RSC ADVANCES
Artículo2015 Conformationally-locked N-glycosides: Exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2015 Correlations between changes in intestinal microbiota composition and performance parameters in broiler chickens JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
Artículo2015 Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: a structure-activity relationship study ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2015 Effects of feed additives on ileal mucosa-associated microbiota composition of broiler chickens JOURNAL OF ANIMAL SCIENCE
Artículo2015 Fluorinated hydroxypiperidines as selective beta-glucosidase inhibitors ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2015 Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery RSC ADVANCES
Artículo2015 Host-Guest-Mediated DNA Templation of Polycationic Supramolecules for Hierarchical Nanocondensation and the Delivery of Gene Material CHEMISTRY-A EUROPEAN JOURNAL
Artículo2015 Inhibition of type 1 fimbriae-mediated Escherichia coli adhesion and biofilm formation by trimeric cluster thiomannosides conjugated to diamond nanoparticles NANOSCALE
Artículo2015 pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Artículo2015 Pharmacological Chaperones and Coenzyme Q(10) Treatment Improves Mutant beta-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease Scientific reports
Artículo2015 Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2015 Supramolecular photochemistry: recent progress and key challenges FARADAY DISCUSSIONS
Artículo2015 Synthesis of High-Mannose Oligosaccharide Analogues through Click Chemistry: True Functional Mimics of Their Natural Counterparts Against Lectins? CHEMISTRY-A EUROPEAN JOURNAL
Artículo2015 Unprecedented inhibition of glycosidase-catalyzed substrate hydrolysis by nanodiamond-grafted Oglycosides RSC ADVANCES
Artículo2014 A Di-D-Fructose Dianhydride-Enriched Caramel Modulates Pig Fecal Microbiota Composition ADVANCES IN MICROBIOLOGY
Ponencia2014 A double diastereoselective Michael-type addition as an entry to Tn antigen mimics and analogs of Thiamet-G XI Carbohydrate Symposium
Ponencia2014 Bicyclic derivatives of L-idonojirimycin as pharmacological chaperones for neuronopathic forms of Gaucher disease MOLECULAR GENETICS AND METABOLISM
Artículo2014 Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities NEW JOURNAL OF CHEMISTRY
Ponencia2014 Design of cationic amphiphilic carbohydrates as modulators of innate inmunity XI Carbohydrate Symposium
Artículo2014 Dynamic Self-Assembly of Polycationic Clusters Based on Cyclodextrins for pH-Sensitive DNA Nanocondensation and Delivery by Component Design CHEMISTRY-A EUROPEAN JOURNAL
Artículo2014 Dynamics of oligo(phenylene-ethynylene) self-assembled monolayers on Au(111) CHEMICAL PHYSICS LETTERS
Ponencia2014 Exploring the structural basis for glycosidase inhibition by multivalent glycomimetics: the "inhibitory multivalent effect" XI Carbohydrate Symposium
Artículo2014 Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-cyclodextrin heterodimers CHEMICAL COMMUNICATIONS
Ponencia2014 Glycosidase inhibitors and effectors as therapeutic tools XI Carbohydrate Symposium
Ponencia2014 Glycotargeted self-assembled nanocarriers from calixarene-cyclodextrin heterodimers for site-specific delivery of docetaxel XI Carbohydrate Symposium
Artículo2014 Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies CHEMICAL COMMUNICATIONS
Artículo2014 Molecular Basis of 1-Deoxygalactonojirimycin Arylthiourea Binding to Human alpha-Galactosidase A: Pharmacological Chaperoning Efficacy on Fabry Disease Mutants ACS CHEMICAL BIOLOGY
Corrección2014 Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds (vol 22, pg 633, 2013) HUMAN MOLECULAR GENETICS
Artículo2014 Self-Assembled Monolayers on Gold of beta-Cyclodextrin Adsorbates with Different Anchoring Groups LANGMUIR
Artículo2014 Structural Basis of Pharmacological Chaperoning for Human beta-Galactosidase JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2014 Synthesis of Multibranched Australine Derivatives from Reducing Castanospermine Analogues through the Amadori Rearrangement of gem-Diamine Intermediates: Selective Inhibitors of beta-Glucosidase JOURNAL OF ORGANIC CHEMISTRY
Artículo2014 Synthesis of substituted exo-glucals via a modified Julia olefination and identification as selective beta-glucosidase inhibitors ORGANIC & BIOMOLECULAR CHEMISTRY
Ponencia2014 Tailoring self-assembling and targeting capabilities of CD-based nanoparticles for gene delivery XI Carbohydrate Symposium
Artículo2014 Targeted delivery of pharmacological chaperones for Gaucher disease to macrophages by a mannosylated cyclodextrin carrier ORGANIC & BIOMOLECULAR CHEMISTRY
Corrección2014 Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases (vol 135, pg 18427, 2013) JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo2014 Trehalose- and Glucose-Derived Glycoamphiphiles: Small-Molecule and Nanoparticle Toll-Like Receptor 4 (TLR4) Modulators JOURNAL OF MEDICINAL CHEMISTRY
Artículo2013 A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM(1) Gangliosidosis MOLECULAR THERAPY
Artículo2013 Amphiphilic Oligoethyleneimine-beta-Cyclodextrin "Click" Clusters for Enhanced DNA Delivery JOURNAL OF ORGANIC CHEMISTRY
Artículo2013 Bicyclic Derivatives of L-Idonojirimycin as Pharmacological Chaperones for Neuronopathic Forms of Gaucher Disease CHEMBIOCHEM
Capítulo2013 Click Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomaterials, and Glycosurfaces Click Chemistry in Glycoscience: New Developments and Strategies
Artículo2013 Competitive processes of a chromophore modified alpha-cyclodextrin in the presence of a fluorescence polarity sensitive probe JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Revisión2013 Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate-protein interactions CHEMICAL SOCIETY REVIEWS
Artículo2013 Cyclodextrin-scaffolded glycotransporters for gene delivery PURE AND APPLIED CHEMISTRY
Capítulo2013 Cyclodextrins for pharmaceutical and biomedical applications SUPRAMOLECULAR SYSTEMS IN BIOMEDICAL FIELDS
Artículo2013 Effects of inulin and di-D-fructose dianhydride-enriched caramels on intestinal microbiota composition and performance of broiler chickens ANIMAL
Ponencia2013 Folate-polycationic amphiphilic cyclodextrin-DNAnanocomplexes for gene delivery in vitro and in vivo HUMAN GENE THERAPY
Artículo2013 Fullerene-sp(2)-Iminosugar Balls as Multimodal Ligands for Lectins and Glycosidases: A Mechanistic Hypothesis for the Inhibitory Multivalent Effect CHEMISTRY-A EUROPEAN JOURNAL
Artículo2013 Influence of the Macroring Size on the Self-Association Thermodynamics of Cyclodextrins with a Double-Linked Naphthalene at the Secondary Face JOURNAL OF PHYSICAL CHEMISTRY B
Artículo2013 Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase BIOCHEMICAL JOURNAL
Revisión2013 Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies CHEMICAL SOCIETY REVIEWS
Artículo2013 N-Thiocarbonyl Iminosugars: Synthesis and Evaluation of Castanospermine Analogues Bearing Oxazole-2(3H)-thione Moieties EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2013 Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds HUMAN MOLECULAR GENETICS
Artículo2013 New Castanospermine Glycoside Analogues Inhibit Breast Cancer Cell Proliferation and Induce Apoptosis without Affecting Normal Cells PLOS ONE
Artículo2013 o-Xylylene Protecting Group in Carbohydrate Chemistry: Application to the Regioselective Protection of a Single vic-Diol Segment in Cyclodextrins JOURNAL OF ORGANIC CHEMISTRY
Artículo2013 Probing the Nature of the Cluster Effect Observed with Synthetic Multivalent Galactosides and Peanut Agglutinin Lectin CHEMISTRY-A EUROPEAN JOURNAL
Artículo2013 Recent Developments on Synthetic Tools Towards Structural and Functional Glycodiversity CURRENT MEDICINAL CHEMISTRY
Artículo2013 Stereoselective Synthesis of 2-Acetamido-1,2-dideoxyallonojirimycin (DAJNAc), a New Potent Hexosaminidase Inhibitor ORGANIC LETTERS
Artículo2013 Targeted gene delivery by new folate-polycationic amphiphilic cyclodextrin-DNA nanocomplexes in vitro and in vivo EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Artículo2013 The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin-Based Iminosugar Click Clusters CHEMBIOCHEM
Artículo2013 Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Ponencia2013 Use of the L-idonojirimycin derivatives as pharmacological chaperones for the treatment of Gaucher disease MOLECULAR GENETICS AND METABOLISM
Artículo2012 Conformationally-Locked N-Glycosides with Selective beta-Glucosidase Inhibitory Activity: Identification of a New Non-Iminosugar-Type Pharmacological Chaperone for Gaucher Disease JOURNAL OF MEDICINAL CHEMISTRY
Artículo2012 Design and synthesis of a "click" high-mannose oligosaccharide mimic emulating Man(8) binding affinity towards Con A CHEMICAL COMMUNICATIONS
Artículo2012 Efficient transfection of hepatocytes mediated by mRNA complexed to galactosylated cyclodextrins BIOCONJUGATE CHEMISTRY
Capítulo2012 Glycotransporters for gene delivery CARBOHYDRATE CHEMISTRY: CHEMICAL AND BIOLOGICAL APPROACHES, VOL 38
Artículo2012 Improving inclusion capabilities of permethylated cyclodextrins by appending a cap-like aromatic moiety TETRAHEDRON
Artículo2012 Monodisperse Nanoparticles from Self-Assembling Amphiphilic Cyclodextrins: Modulable Tools for the Encapsulation and Controlled Release of Pharmaceuticals MEDICINAL CHEMISTRY
Artículo2012 Polycationic amphiphilic cyclodextrins as gene vectors: effect of the macrocyclic ring size on the DNA complexing and delivery properties ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2012 Probing Carbohydrate-Lectin Recognition in Heterogeneous Environments with Monodisperse Cyclodextrin-Based Glycoclusters JOURNAL OF ORGANIC CHEMISTRY
Artículo2012 Scalable Syntheses of Both Enantiomers of DNJNAc and DGJNAc from Glucuronolactone: The Effect of N-Alkylation on Hexosaminidase Inhibition CHEMISTRY-A EUROPEAN JOURNAL
Artículo2012 sp2-Iminosugar O-, S-, and N-Glycosides as Conformational Mimics of a-Linked Disaccharides; Implications for Glycosidase Inhibition CHEMISTRY-A EUROPEAN JOURNAL
Revisión2012 Synthesis and Biophysical Study of Disassembling Nanohybrid Bioconjugates with a Cubic Octasilsesquioxane Core ADVANCED FUNCTIONAL MATERIALS
Artículo2012 Synthesis and glycosidase inhibitory activity of isourea-type bicyclic sp(2)-iminosugars related to galactonojirimycin and allonojirimycin TETRAHEDRON
Artículo2012 Tuning glycosidase inhibition through aglycone interactions: pharmacological chaperones for Fabry disease and GM(1) gangliosidosis CHEMICAL COMMUNICATIONS
Artículo2011 Amphiphilic 1-Deoxynojirimycin Derivatives through Click Strategies for Chemical Chaperoning in N370S Gaucher Cells JOURNAL OF ORGANIC CHEMISTRY
Artículo2011 beta-Cyclodextrin-Based Polycationic Amphiphilic "Click" Clusters: Effect of Structural Modifications in Their DNA Complexing and Delivery Properties JOURNAL OF ORGANIC CHEMISTRY
Artículo2011 Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards beta-glucocerebrosidase ORGANIC & BIOMOLECULAR CHEMISTRY
Revisión2011 Cyclodextrin-based gene delivery systems CHEMICAL SOCIETY REVIEWS
Artículo2011 Cyclodextrin-mediated crystallization of acid beta-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2011 Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery BIOMATERIALS
Revisión2011 Pharmacological chaperone therapy for Gaucher disease: a patent review EXPERT OPINION ON THERAPEUTIC PATENTS
Artículo2011 Polycationic amphiphilic cyclodextrin-based nanoparticles for therapeutic gene delivery NANOMEDICINE
Artículo2011 Self-association of a naphthalene-capped-beta-cyclodextrin through cooperative strong hydrophobic interactions JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Artículo2011 Stereoselective Synthesis of Difructose Dianhydrides by Use of the Xylylene Group as Stereodirecting Element in Spiroketalisation Reactions EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2011 Symmetry Complementarity-Guided Design of Anthrax Toxin Inhibitors Based on beta-Cyclodextrin: Synthesis and Relative Activities of Face-Selective Functionalized Polycationic Clusters CHEMMEDCHEM
Artículo2011 The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Architectural Parameters with Cyclodextrin-based Iminosugar Click Clusters CHEMISTRY-A EUROPEAN JOURNAL
Revisión2010 (Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Artículo2010 A Fluorescent sp(2)-Iminosugar With Pharmacological Chaperone Activity for Gaucher Disease: Synthesis and Intracellular Distribution Studies CHEMBIOCHEM
Artículo2010 Comparative studies on lectin-carbohydrate interactions in low and high density homo- and heteroglycoclusters ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2010 Di-D-fructose Dianhydride-Enriched Caramels: Effect on Colon Microbiota, Inflammation, and Tissue Damage in Trinitrobenzenesulfonic Acid-Induced Colitic Rats JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2010 Di-D-fructose Dianhydride-Enriched Products by Acid Ion-Exchange Resin-Promoted Caramelization of D-Fructose: Chemical Analyses JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Revisión2010 Difructose Dianhydrides (DFAs) and DFA-Enriched Products as Functional Foods CARBOHYDRATES IN SUSTAINABLE DEVELOPMENT I: RENEWABLE RESOURCES FOR CHEMISTRY AND BIOTECHNOLOGY
Artículo2010 Fluorescent-tagged sp(2)-iminosugars with potent beta-glucosidase inhibitory activity BIOORGANIC & MEDICINAL CHEMISTRY
Artículo2010 Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Artículo2010 Insights in cellular uptake mechanisms of pDNA-polycationic amphiphilic cyclodextrin nanoparticles (CDplexes) JOURNAL OF CONTROLLED RELEASE
Artículo2010 Preorganized, Macromolecular, Gene-Delivery Systems CHEMISTRY-A EUROPEAN JOURNAL
Corrección2010 Preorganized, Macromolecular, GeneDelivery Systems (vol 16, pg 4907, 2010) CHEMISTRY-A EUROPEAN JOURNAL
Artículo2010 Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral alpha-glucosidase inhibitory activity as antitumour agents CHEMICAL COMMUNICATIONS
Artículo2009 6-Amino-6-deoxy-5,6-di-N-(N '-octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid beta-Glucosidase CHEMBIOCHEM
Artículo2009 Chaperone Activity of Bicyclic Nojirimycin Analogues for Gaucher Mutations in Comparison with N-(n-nonyl)-Deoxynojirimycin CHEMBIOCHEM
Artículo2009 Generalized Anomeric Effect in gem-Diamines: Stereoselective Synthesis of alpha-N-Linked Disaccharide Mimics ORGANIC LETTERS
Artículo2009 Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2009 Multivalent iminosugars to modulate affinity and selectivity for glycosidases ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2009 Polycationic Amphiphilic Cyclodextrins for Gene Delivery: Synthesis and Effect of Structural Modifications on Plasmid DNA Complex Stability, Cytotoxicity, and Gene Expression CHEMISTRY-A EUROPEAN JOURNAL
Artículo2009 Preorganized macromolecular gene delivery systems: amphiphilic beta-cyclodextrin "click clusters" ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2009 Regioselective synthesis and biological evaluation of spiro-sulfamidate glycosides from exo-glycals TETRAHEDRON-ASYMMETRY
Artículo2009 Size-Tunable Trehalose-Based Nanocavities: Synthesis, Structure, and Inclusion Properties of Large-Ring Cyclotrehalans JOURNAL OF ORGANIC CHEMISTRY
Artículo2009 Synthesis of Thiohydantoin-Castanospermine Glycomimetics as Glycosidase Inhibitors JOURNAL OF ORGANIC CHEMISTRY
Artículo2009 Thermodynamics of the Dimer Formation of 2(I),3(I)-O-(o-Xylylene)-per-O-Me-gamma-cyclodextrin: Fluorescence, Molecular Mechanics and Molecular Dynamics JOURNAL OF FLUORESCENCE
Revisión2008 Asymmetric synthesis of N,O,O,O-tetra-acetyl D-lyxo-phytosphingosine, jaspine B (pachastrissamine), 2-epi-jaspine B, and deoxoprosophylline via lithium amide conjugate addition ORGANIC & BIOMOLECULAR CHEMISTRY
Corrección2008 Asymmetric synthesis of N,O,O,O-tetra-acetyl D-lyxo-phytosphingosine, jaspine B (pachastrissamine), 2-epi-jaspine B, and deoxoprosophylline via lithium amide conjugate addition (vol 6, pg 1665, 2008) ORGANIC & BIOMOLECULAR CHEMISTRY
Revisión2008 Chemical and enzymatic approaches to carbohydrate-derived spiroketals: Di-D-fructose dianhydrides (DFAs) MOLECULES
Artículo2008 Molecular Basis for beta-Glucosidase Inhibition by Ring-Modified Calystegine Analogues CHEMBIOCHEM
Artículo2008 Rational design of cationic cyclooligosaccharides as efficient gene delivery systems CHEMICAL COMMUNICATIONS
Artículo2008 Stereoselective synthesis of nonsymmetrical difructose dianhydrides from xylylene-tethered D-fructose precursors TETRAHEDRON
Artículo2008 Study of the Conformational and Self-Aggregation Properties of 2(I),3(I)-O-(o-Xylylene)-per-O-Me-alpha- and beta-cyclodextrins by Fluorescence and Molecular Modeling JOURNAL OF PHYSICAL CHEMISTRY B
Artículo2008 Synthesis and biological evaluation of guanidine-type iminosugars JOURNAL OF ORGANIC CHEMISTRY
Artículo2008 Synthesis and evaluation of sulfamide-type indolizidines as glycosidase inhibitors BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Artículo2008 Synthesis, structure, and inclusion capabilities of trehalose-based cyclodextrin analogues (Cyclotrehalans) JOURNAL OF ORGANIC CHEMISTRY
Artículo2008 Tailoring beta-Cyclodextrin for DNA Complexation and Delivery by Homogeneous Functionalization at the Secondary Face ORGANIC LETTERS
Ponencia2008 Targeted beta-cyclodextrine-based gene delivery systems: Physicochemical and transfection studies HUMAN GENE THERAPY
Artículo2007 Asymmetric synthesis of N,O,O,O-tetra-acetyl D-lyxo-phytosphingosine, jaspine B (pachastrissamine) and its C(2)-epimer TETRAHEDRON-ASYMMETRY
Artículo2007 Bis antennae amphiphilic cyclodextrins: the first examples TETRAHEDRON LETTERS
Artículo2007 Couplings of benzylic halides mediated by titanocene chloride: synthesis of bibenzyl derivatives JOURNAL OF ORGANIC CHEMISTRY
Artículo2007 Efficient use of Ellman safety-catch linker for solid-phase assisted synthesis of multivalent glycoconjugates JOURNAL OF COMBINATORIAL CHEMISTRY
Capítulo2007 Glycosidase Inhibitors: Structure, Activity, Synthesis, and Medical Relevance Comprehensive Glycoscience: From Chemistry to Systems Biology
Artículo2007 High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Artículo2007 Les cyclodextrines en pharmacie: Perspectives pour le ciblage d actifs thérapeutiques et le contrôle d interactions membranaires || Pharmaceutical use of cyclodextrines: Perspectives for drug targeting and control of membrane interactions Annales Pharmaceutiques Françaises
Artículo2007 Mild TiIII- and Mn/ZrIV-catalytic reductive coupling of allylic halides: Efficient synthesis of symmetric terpenes JOURNAL OF ORGANIC CHEMISTRY
Artículo2007 Multi-mannosides based on a carbohydrate scaffold: Synthesis, force field development, molecular dynamics studies, and binding affinities for lectin Con A JOURNAL OF ORGANIC CHEMISTRY
Artículo2007 One-pot regioselective synthesis of 2(I),3(I)-O-(o-xylylene)-capped cyclomaltooligosaccharides: tailoring the topology and supramolecular properties of cyclodextrins CHEMICAL COMMUNICATIONS
Artículo2007 Promoting helicity in carbohydrate-containing foldamers through long-range hydrogen bonds CHEMICAL COMMUNICATIONS
Artículo2007 Spacer-mediated synthesis of bis-spiroketal disaccharides: Nonsymmetrical furanose-pyranose difructose dianhydrides SYNLETT
Artículo2007 Supramolecular chemistry of carbohydrate clusters with cores having guest binding abilities MINI-REVIEWS IN ORGANIC CHEMISTRY
Artículo2007 Synthesis and biological evaluation of 6-oxa-nor-tropane glycomimetics as glycosidase inhibitors TETRAHEDRON
Artículo2007 Synthesis of alpha- and beta-glycosyl isothiocyanates via oxazoline intermediates JOURNAL OF ORGANIC CHEMISTRY
Artículo2007 Synthesis of thiourea-linked glycooligomers that mimic the branching patterns of natural oligosaccharides SYNTHESIS-STUTTGART
Artículo2007 Trehalose-based cyclodextrin analogs: cyclotrehalans (CTs) Journal of Inclusion Phenomena and Macrocyclic Chemistry
Artículo2006 Asymmetric synthesis of alpha-mercapto-beta-amino acid derivatives: application to the synthesis of polysubstituted thiomorpholines TETRAHEDRON-ASYMMETRY
Artículo2006 Chemical composition of the essential oil from the leaves of juniperus phoenicea l. from north africa Journal of Essential Oil Research
Artículo2006 Cyclodextrin derivatives with cyanohydrin and carboxylate groups as artificial glycosidases CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE
Artículo2006 Glyconanocavities: Cyclodextrins and beyond Journal of Inclusion Phenomena and Macrocyclic Chemistry
Artículo2006 Intramolecular benzyl protection delivery: A practical synthesis of DMDP and DGDP from D-fructose ORGANIC LETTERS
Artículo2006 Regio- and diastereoselective reductive coupling of vinylepoxides catalyzed by titanocene chloride ORGANIC LETTERS
Artículo2006 Solid-phase selenium-catalyzed selective allylic chlorination of polyprenoids: facile syntheses of biologically active terpenoids JOURNAL OF ORGANIC CHEMISTRY
Artículo2006 Spacer-mediated synthesis of contra-thermodynamic spiroacetals: Stereoselective synthesis of C-2-symmetric difructose dianhydrides JOURNAL OF ORGANIC CHEMISTRY
Artículo2006 Synthesis and biological evaluation of glycosidase inhibitors: gem-difluoromethylenated nojirimycin analogues JOURNAL OF MEDICINAL CHEMISTRY
Artículo2006 Synthesis of five- to seven-membered polyfunctional terpenic carbocycles via ti(iii)-catalyzed radical cyclizations of epoxypolyprenes: nature-inspired approaches to chemical synthesis TETRAHEDRON
Artículo2006 The o-xylylene protecting group as an element of conformational control of remote stereochemistry in the synthesis of spiroketals CHEMICAL COMMUNICATIONS
Artículo2006 The synthesis and structure of linear and dendritic thiourea-linked glycooligomers EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Revisión2006 Titanocene-mediated radical cyclization: an emergent method towards the synthesis of natural products EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2006 Transannular cyclization of epoxycaryophyllenes catalyzed by ti-iii: an efficient synthesis of tricyclo[6.3.0.0(2,5)]undecanes EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2006 Urea-, thiourea-, and guanidine-linked glycooligomers as phosphate binders in water JOURNAL OF ORGANIC CHEMISTRY
Artículo2005 1,2,3-Triazoles and related glycoconjugates as new glycosidase inhibitors TETRAHEDRON
Artículo2005 Artificial glycosyl phosphorylases CHEMISTRY-A EUROPEAN JOURNAL
Artículo2005 Four orders of magnitude rate increase in artificial enzyme-catalyzed aryl glycoside hydrolysis JOURNAL OF ORGANIC CHEMISTRY
Capítulo2005 Identificación y cuantificación de azúcares resultantes de la dimerización de la sacarosa y de la d-fructosa (dianhídricos de fructosa) formados en la raíz de remolacha o durante su procesado industrial Aspectos fisiológicos de la remolacha azucarera de siembra otoñal
Artículo2005 Mild protocols for generating molecular complexity: A comparative study of hetero-domino reactions based on the oxidant and the substitution pattern EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2005 Modeling the effect of substitution on the pb(oac) 4 mediated oxidative cleavage of steroidal 1,2-diols JOURNAL OF ORGANIC CHEMISTRY
Artículo2005 Probing secondary carbohydrate-protein interactions with highly dense cyclodextrin-centered heteroglycoclusters: The heterocluster effect JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo2005 Reductive coupling of terpenic allylic halides catalyzed by cp2ticl: a short and efficient asymmetric synthesis of onocerane triterpenes ORGANIC LETTERS
Artículo2005 Remarkable supramolecular catalysis of glycoside hydrolysis by a cyclodextrin cyanohydrin JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo2005 Rigid spacer-mediated synthesis of bis-spiroketal ring systems: stereoselective synthesis nonsymmetrical spiro of disaccharides ORGANIC LETTERS
Artículo2005 Sulfanyl radical-induced cyclization of linalyl acetate to the iridane skeleton: a short synthesis of (+/-)-dehydroiridomyrmecin SYNLETT
Artículo2005 Synthesis and comparative glycosidase inhibitory properties of reducing castanospermine analogues EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2004 A general entry to linear, dendritic and branched thiourea-linked glycooligomers as new motifs for phosphate ester recognition in water CHEMICAL COMMUNICATIONS
Artículo2004 Carbohydrate-derived spiroketals: stereoselective synthesis of di-D-fructose dianhydrides TETRAHEDRON
Artículo2004 Functional evaluation of carbohydrate-centred glycoclusters by enzyme-linked lectin assay: Ligands for concanavalin A CHEMBIOCHEM
Artículo2004 Optimizing saccharide-directed molecular delivery to biological receptors: Design, synthesis, and biological evaluation of glycodendrimer - Cyclodextrin conjugates JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo2004 Pseudoamide-type pyrrolidine and pyrrolizidine glycomimetics and their inhibitory activities against glycosidases JOURNAL OF ORGANIC CHEMISTRY
Libro2004 Síntesis y reconocimiento molecular de glicoclústeres y glicodendrímeros sobre un núcleo de B-ciclodextrina Síntesis y reconocimiento molecular de glicoclústeres y glicodendrímeros sobre un núcleo de B-ciclodextrina
Artículo2004 Synthesis of calystegine B-2, B-3, and B-4 analogues: Mapping the structure-glycosidase inhibitory activity relationships in the 1-deoxy-6-oxacalystegine series EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2004 Synthesis of nitrogen-functionalized beta-cycloaltrins JOURNAL OF ORGANIC CHEMISTRY
Artículo2004 Synthesis of sugar oxazolines by intramolecular Ritter-like reaction of D-fructose precursors SYNLETT
Artículo2003 Carbohydrate-derived spiroketals: Stereoselective synthesis of di-D-fructose dianhydrides via intramolecular aglycon delivery ORGANIC LETTERS
Artículo2003 Diverse motifs of mannoside clustering on a beta-cyclodextrin core ORGANIC LETTERS
Artículo2003 Lead tetraacetate mediated domino reactions on (R)-(-)-carvone-derived bicyclic unsaturated 1,2-diols and further rearrangements TETRAHEDRON-ASYMMETRY
Artículo2003 Synthesis and evaluation of isourea-type glycomimetics related to the indolizidine and trehazolin glycosidase inhibitor families JOURNAL OF ORGANIC CHEMISTRY
Artículo2003 Synthesis of (1S,2S,3R,8S,8aR)-1,2,3,8-tetrahydroxy-6-oxa-5-thioxoindolizidine: A stable reducing swainsonine analog with controlled anomeric configuration SYNLETT
Artículo2002 Carbohydrate microarrays CHEMBIOCHEM
Artículo2002 Castanospermine-trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties CHEMICAL COMMUNICATIONS
Artículo2002 Cyclotrehalins: Cyclooligosaccharide receptors featuring a hydrophobic cavity ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Artículo2002 Dendritic galactosides based on a beta-cyclodextrin core for the construction of site-specific molecular delivery systems: Synthesis and molecular recognition studies CHEMISTRY-A EUROPEAN JOURNAL
Corrección2002 Erratum: (Angewandte Chemie - International Edition (2002) 19 (3674-3676)) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Artículo2002 Multivalent cyclooligosaccharides: Versatile carbohydrate clusters with dual role as molecular receptors and lectin ligands CHEMISTRY-A EUROPEAN JOURNAL
Artículo2002 One-step synthesis of non-anomeric sugar isothiocyanates from sugar azides CARBOHYDRATE RESEARCH
Artículo2001 Analysis of the interaction between lectins and tetra- and tri-saccharide mimics of the Sd(a) determinant by surface plasmon resonance detection BIOCHIMIE
Artículo2001 Binding affinity properties of dendritic glycosides based on a beta-cyclodextrin core toward guest molecules and concanavalin A JOURNAL OF ORGANIC CHEMISTRY
Artículo2001 Carbohydrate-based receptors with multiple thiourea binding sites. Multipoint hydrogen bond recognition of dicarboxylates and monosaccharides JOURNAL OF ORGANIC CHEMISTRY
Artículo2001 Carbohydrate-derived spiroketals. stereoselective synthesis of di-D-fructose dianhydrides by boron trifluoride promoted glycosylation-spiroketalization of acetal precursors ORGANIC LETTERS
Artículo2001 Dependence of concanavalin A binding on anomeric configuration, linkage type, and ligand multiplicity for thiourea-bridged mannopyranosyl-beta-cyclodextrin conjugates CHEMBIOCHEM
Artículo2001 Epitope diversity of N-glycans from bovine peripheral myelin glycoprotein P0 revealed by mass spectrometry and nano probe magic angle spinning H-1 NMR spectroscopy JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2001 Quantitative determination of intermolecular interactions with fluorinated aromatic rings CHEMISTRY-A EUROPEAN JOURNAL
Artículo2001 Synthesis and evaluation of calystegine B-2 analogues as glycosidase inhibitors JOURNAL OF ORGANIC CHEMISTRY
Artículo2001 Synthesis of beta-cyclodextrin, per-O-glycosylated through an ethylene glycol spacer arm SYNTHESIS-STUTTGART
Revisión2000 Chemistry and developments of N-thiocarbonyl carbohydrate derivatives: Sugar isothiocyanates, thioamides, thioureas, thiocarbamates, and their conjugates ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, VOL 55
Artículo2000 Conformational analysis of the Sd(a) determinant-containing tetrasaccharide and two mimics in aqueous solution by using H-1 NMR ROESY spectroscopy in combination with MD simulations Journal of Biomolecular NMR
Artículo2000 Generalized anomeric effect in action: Synthesis and evaluation of stable reducing indolizidine glycomimetics as glycosidase inhibitors JOURNAL OF ORGANIC CHEMISTRY
Artículo2000 Nitrogen versus sulfur acylation in sugar thioureas: regioselectivity and conformational consequences TETRAHEDRON-ASYMMETRY
Artículo2000 Synthesis and comparative lectin-binding affinity of mannosyl-coated beta-cyclodextrin-dendrimer constructs CHEMICAL COMMUNICATIONS
Artículo2000 Synthesis of glycosyl(thio)ureido sugars via carbodiimides and their conformational behaviour in water CARBOHYDRATE RESEARCH
Artículo1999 A practical amine-free synthesis of symmetric ureas and thioureas by self-condensation of iso(thio)cyanates SYNTHESIS-STUTTGART
Ponencia1999 Influence of substituents on the edge-to-face aromatic interaction: Halogens NMR IN SUPRAMOLECULAR CHEMISTRY
Ponencia1999 Investigation of the inclusion complex and stoichiometry of omeprazole with beta-CD by H-1 NMR spectroscopy PROCEEDINGS OF THE 9TH INTERNATIONAL SYMPOSIUM ON CYCLODEXTRINS
Artículo1999 Polyhydroxylated N-(thio)carbamoyl piperidines: nojirimycin-type glycomimetics with controlled anomeric configuration TETRAHEDRON-ASYMMETRY
Artículo1999 S-linked thiomimetics of phytoalexin-elicitor-active, branched oligosaccharides, their synthesis, protein-binding ability and phytoalexin-inducing activity EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo1999 Sugar thioureas as anion receptors. Effect of intramolecular hydrogen bonding in the carboxylate binding properties of symmetric sugar thioureas ORGANIC LETTERS
Artículo1999 Synthesis and anomeric stability of (1 -> 6)-thiourea-linked pseudooligosaccharides CARBOHYDRATE RESEARCH
Artículo1999 Synthesis of 6,7-dideoxy-7-isothiocyanatoheptoses: Stable fully unprotected monosaccharide isothiocyanates CARBOHYDRATE RESEARCH
Ponencia1999 Thiourea-bridged beta-cyclodextrin conjugates PROCEEDINGS OF THE 9TH INTERNATIONAL SYMPOSIUM ON CYCLODEXTRINS
Artículo1998 Cyclodextrin-scaffolded glycoclusters CHEMISTRY-A EUROPEAN JOURNAL
Ponencia1998 Macrocyclic sugar thioureas: Cyclooligosaccharides mimicking cyclopeptides MOLECULAR RECOGNITION AND INCLUSION
Artículo1998 Sulfur atom participation in thiooligosaccharide chemistry: Synthesis of 1 '-thiotrehalulose and 1 '-epi-thiotrehalulose and comparative reactivity with the O-linked disaccharide analogue, trehalulose JOURNAL OF ORGANIC CHEMISTRY
Artículo1998 Synthesis and stereoelectronic properties of sugar-shaped polyhydroxylated hexahydropyrimidine-2-thiones TETRAHEDRON
Artículo1998 Synthesis of calystegine B2 analogs by tandem tautomerization-intramolecular glycosylation of thioureidosugars SYNLETT
Ponencia1998 Thioureido beta-cyclodextrins as molecular carriers for the anticancer drug Taxotere (R) MOLECULAR RECOGNITION AND INCLUSION
Artículo1997 A mild one-step selective conversion of primary hydroxyl groups into azides in mono- and oligo-saccharides CARBOHYDRATE RESEARCH
Artículo1997 Aza-Wittig reaction of sugar isothiocyanates and sugar iminophosphoranes: An easy entry to unsymmetrical sugar carbodiimides TETRAHEDRON LETTERS
Artículo1997 N-thiocarbonyl azasugars: a new family of carbohydrate mimics with controlled anomeric configuration CHEMICAL COMMUNICATIONS
Artículo1997 Synthesis of (1 → 6)-carbodiimide-tethered pseudooligosaccharides via aza-Wittig reaction CARBOHYDRATE RESEARCH
Artículo1996 Conformational energetics of sugar thioureas and synthesis of glycosyl thioureido sugars TETRAHEDRON
Artículo1996 Influence of intramolecular hydrogen-bonding on the conformation of 3-deoxy-3-thioureido sugars CARBOHYDRATE RESEARCH
Artículo1996 Stereocontrolled synthesis of sulfur-linked analogues of the branched tetrasaccharide repeating-unit of the immunostimulant polysaccharide schizophyllan and of its beta-(1->3)-branched, beta-(1->6)-linked isomer CARBOHYDRATE RESEARCH
Artículo1996 Synthesis of sulfur-linked analogues of nigerose, laminarabiose, laminaratriose, gentiobiose, gentiotriose, and laminaran trisaccharide Y CARBOHYDRATE RESEARCH
Artículo1996 Tautomeric rearrangement of 3-deoxy-3-thioureidoaldoses: A novel synthetic route to carbohydrate mimics having a cyclic thiourea structure CHEMICAL COMMUNICATIONS
Artículo1996 Thioureido-beta-cyclodextrins as molecular carriers CHEMICAL COMMUNICATIONS
Nota1995 A mild and efficient procedure to remove acetal and dithioacetal protecting groups in carbohydrate-derivatives using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone CARBOHYDRATE RESEARCH
Artículo1995 Isothiocyanoates and cyclic thiocarbamates of alpha,alpha'-trehalose sucrose, and cyclomaltooligosaccharides CARBOHYDRATE RESEARCH
Artículo1995 O-acetyl protection of 6-aminoaldopyranosides and 1-aminoalditols JOURNAL OF CARBOHYDRATE CHEMISTRY
Artículo1995 Synthesis, conformational flexibility and preliminary complexation behavior of alpha,alpha'-trehalose-based macrocycles containing thiourea spacers JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS
Nota1994 1-deoxy-1-isothiocyanato-d-fructose as intermediate in syntheses of 1,3-o(s),n-heterocycles CARBOHYDRATE RESEARCH
Nota1994 A d-ribofuranosylenamine as glycosyl acceptor CARBOHYDRATE RESEARCH
Artículo1994 Enantiopure 2-thioxotetrahydro-1,3-o,n-heterocycles from carbohydrates .3. enantiopure c-4 chiral oxazine-2-thiones and oxazolidine-2-thiones from 3-deoxy-3-isothiocyanato sugars JOURNAL OF ORGANIC CHEMISTRY
Artículo1994 Influence of intramolecular hydrogen-bonding on the conformational properties of sugar thioureas TETRAHEDRON-ASYMMETRY
Artículo1994 Synthesis and conformational properties of sugar amides and thioamides TETRAHEDRON-ASYMMETRY
Artículo1993 A cyclization-trapping route to carbocyclic and heterocyclic benzylic sulfones TETRAHEDRON LETTERS
Artículo1993 Building-blocks for glycopeptide synthesis - disaccharide glycosyl isothiocyanates JOURNAL OF CARBOHYDRATE CHEMISTRY
Artículo1993 Chiral 2-Thioxotetrahydro-1,3-O,N-heterocycles from Carbohydrates. 2. Stereocontrolled Synthesis of Oxazolidine Pseudo-C-nucleosides and Bicyclic Oxazine-2-thiones JOURNAL OF ORGANIC CHEMISTRY
Artículo1992 Chiral 2-thioxotetrahydro-1,3-o,n-heterocycles from carbohydrates TETRAHEDRON LETTERS
Artículo1992 Glucosylenamines as glycosyl acceptors - synthesis of gentiobiosylenamines CARBOHYDRATE RESEARCH
Artículo1992 Partially protected d-glucopyranosyl isothiocyanates - synthesis and transformations into thiourea and heterocyclic-derivatives TETRAHEDRON
Artículo1992 Syntheses of β-iodourea derivatives of carbohydrates and glycosylamino-oxazolines CARBOHYDRATE RESEARCH
Artículo1991 Syntheses and spectral properties of beta-iodoureas and 2-amino-4,4-diphenyl-2-oxazolines JOURNAL OF HETEROCYCLIC CHEMISTRY
Artículo1991 Syntheses of beta-iodourea derivatives of carbohydrates and glycosylamino-oxazolines CARBOHYDRATE RESEARCH
Artículo1990 N-glycosyl-N'-carbonylmethylthioureas Anales de Química
Artículo1990 Regioselective benzoylations of d-xylopyranosylenamines and d-ribopyranosylenamines Journal of Chemical Research
Artículo1990 Synthesis of n-hetarylthiourea derivatives of carbohydrates JOURNAL OF CARBOHYDRATE CHEMISTRY
Artículo1989 Regioselective benzoylations of glycopyranosylamines: synthesis of partially protected glycopyranosyl isothiocyanates CARBOHYDRATE RESEARCH
Nota1989 Thiourea derivatives of carbohydrates .13. Syntheses of partially protected d-galactopyranosylthioureas - new d-galactopyranosylimidazoline-2-thiones and d-galactopyranosylaminothiazoles CARBOHYDRATE RESEARCH
Artículo1988 Syntheses of d-ribosylamines, d-ribopyranosyl isothiocyanates, and d-ribopyranosylthioureas, and their transformations into heterocyclic compounds CARBOHYDRATE RESEARCH
Artículo1988 Thiourea derivatives of carbohydrates .12. Syntheses of d-ribosylamines, d-ribopyranosyl isothiocyanates, and d-ribopyranosylthioureas, and their transformations into heterocyclic-compounds CARBOHYDRATE RESEARCH
Nota1987 Glycosil aminothiazole derivatives of d-glucosamina and d-galactose ANALES DE QUIMICA SERIE C-QUIMICA ORGANICA Y BIOQUIMICA
Artículo1987 Phenacylthiourea and N-thiazolyl derivatives of 2-amino-2-deoxy-d-glucose CARBOHYDRATE RESEARCH
Nota1987 Thiourea derivatives of carbohydrates .10. Phenacylthiourea and n-thiazolyl derivatives of 2-amino-2-deoxy-d-glucose CARBOHYDRATE RESEARCH
Artículo1986 Synthesis of 1,3,4,6-tetra-O-acetyl-2-[3-alkyl-(aryl)-thioreido]-2-deoxy-α-d-glucopyranoses and their transformation into 2-alkyl(aryl)amino-(1,2-dideoxy-α-d-glucopyrano)[2,1-d]-2-thiazolines CARBOHYDRATE RESEARCH
Artículo1986 Thiourea derivatives of carbohydrates .6. Synthesis of 1,3,4,6-tetra-o-acetyl-2-[3-alkyl(aryl)-thioureido]-2-deoxy-alpha-d-glucopyranoses and their transformation into 2-alkyl(aryl)amino-(1,2-dideoxy-alpha-d-glucopyrano)[2,1-d]-2-thiazolines CARBOHYDRATE RESEARCH
Nota1986 Thiourea derivatives of carbohydrates .7. Synthesis of glycosylaminothiazoles CARBOHYDRATE RESEARCH
Artículo1984 Thioureas derivatives of carbohydrates .4. Reaction of glycosylisothiothyanates and alpha-aminoketones hydrochlorides ANALES DE QUIMICA SERIE C-QUIMICA ORGANICA Y BIOQUIMICA
Artículo1984 Tioureas derivadas de carbohidratos. IV. Reacción de glicosilisotiocianatos con ∝-aminocetonas hidrocloruros ANALES DE QUIMICA SERIE C-QUIMICA ORGANICA Y BIOQUIMICA
Artículo1983 Thioureas derivatives of carbohydrates .3. Synthesis of glucosylthioureas and thioureas derivatives of d-glucosamine ANALES DE QUIMICA SERIE C-QUIMICA ORGANICA Y BIOQUIMICA
Artículo1983 Tioureas derivadas de carbohidratos III. Síntesis de glucosiltioureas y de nuevas tioureas derivadas de la D-glucosamina Anales de la Real Sociedad Española de Química

Proyectos de Investigación

Fecha de inicio Fecha de fin Denominación Agencia financiadora Importe concedido
01/09/2023 31/08/2026 Sinergia entre inmuno-glico-compuestos y nanoplataformas basadas en redes metal-orgánicas: un enfoque multimodal para la regulación de la respuesta inmune (PID2022-141034OB-C21) Ministerio de Ciencia e Innovación (Nacional) 175.000,00 €
01/01/2022 31/12/2022 Reconocimiento cruzado de glicosidasas y lectinas: Mecanismos y oportunidades en el desarrollo de fármacos multidiana (US-1380698) Consejería de Economía, Conocimiento, Empresas y Universidad (Autonómico) 80.000,00 €
01/06/2020 31/05/2023 Miméticos de Glicoconjugados: Nuevas Estrategias en Glicomedicina Dirigidas a Enfermedades Neurológicas y del Sistema Immune (PID2019-105858RB-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional) 139.150,00 €
30/12/2016 31/12/2020 Terapias Basadas en Glicomiméticos para el Tratamiento de Enfermedades de Plegamiento de Proteínas, Inflamación y Cáncer. (SAF2016-76083-R) Ministerio de Economía y Competitividad (Nacional) 169.400,00 €
01/01/2014 31/12/2017 Chaperonas, Inhibidores y Nutracéuticos Basados en Carbohidratos para Aplicaciones Biomédicas: Desórdenes de Depósito Lisosomal, Cáncer y Enfermedad de Crohn (SAF2013-44021-R) Ministerio de Economía y Competitividad (Nacional) 217.800,00 €
01/07/2013 30/06/2017 Glycodrugs: new strategies for controlling the activity of glycosidase enzymes and their application in therapies for lysosomal storage diseases and cancer (GLYCODRUGS) (333594) Commission of the European Communities (Europeo) 100.000,00 €
01/09/2011 31/08/2014 Fabrication of particles with photo receptors: bio-analytical application such as controlled drug delivery (269099) Comisión Europea (Europeo) 15.200,00 €
01/01/2011 30/06/2014 Glicobióticos, Glicofármacos y Glicotransportadores: Aplicaciones en Nutrición y Biomedicina (SAF2010-15670) Ministerio de Ciencia e Innovación (Nacional) 157.300,00 €
16/03/2010 16/03/2013 Iminoazúcares sp2 como chaperonas químicas: una estrategia general para el tratamiento de desórdenes de almacenamiento lisosomial (FRA2009-001) Fundación Ramón Areces (Nacional) 118.860,00 €
13/01/2009 31/12/2013 Diseño de Inhibidores de Glicosidasas para el Tratamiento de Enfermedades Lisosomiales: Sintesis de Sp2-Azucares y Evaluación en Terapias de Acompañante Químico (P08-FQM-03711) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico) 178.323,68 €
01/10/2008 30/06/2010 Caramelos prebióticos y su utilización como alimentos funcionales (CICEACN08-001) Junta de Andalucía (Consejería de Innovación, Ciencia y Empresas) (Autonómico) 188.000,00 €
01/10/2007 31/03/2011 Glicobióticos y glicofármacos: preparación y evaluación de carbohidratos con actividad probiótica (DAFs) y biomédica (ganglosidosis GM1 y ántrax) (CTQ2007-61180) Ministerio de Educación y Ciencia (Nacional) 169.400,00 €
13/04/2007 12/04/2010 Preparación, análisis y evaluación de oligosacáridos prebióticos derivados de sacarosa, fructosa y lactosa (P06-AGR-02150) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico) 121.536,30 €
13/12/2004 13/12/2007 Glicomiméticos mono y ologosacarídicos y estudio de sus interacciones con biomoléculas (CTQ2004-05854) Ministerio de Ciencia y Tecnología (Nacional) 100.150,00 €
28/12/2001 27/06/2005 Síntesis y evaluación de glicomiméticos como inhibidores de glicosidasas. Aplicaciones al estudio del modo de acción de invertasas y sacarosa sintasa en plantas (BMC2001-2366-C03-03) Ministerio de Ciencia y Tecnología (Nacional) 55.293,11 €
01/10/1998 01/10/2001 NUEVOS METODOS DE FORMACION ESTEREOSELECTIVA DE ENLACES CARBONO-CARBONO: UTILIZACION DE HIDRAZONAS N,N-DISUSTITUIDAS EN REACCIONES DE ADICION NUCLEOFILICAS,ELECTROFILICAS Y DE CICLOADICION. (PB97-0747) 60.101,21 €
01/10/1997 01/10/2000 SINTESIS DE CICLODEXTRINAS RAMIFICADAS E HIPERRAMIFICADAS (PB96-1505) 27.045,55 €

Contratos

Fecha de inicio Fecha de fin Denominación Agencia financiadora Importe concedido
09/01/2024 08/04/2024 Caracterización y elaboración de un Informe sobre Muestras de Mortero y Pátinas de la Iglesia de Montealegre del Castillo (Albacete) (5038/0056) Restauraciones Capitel, S.L. (Desconocido)
10/05/2023 09/08/2023 Estudio mediante DRX y microscopia FTIR de los enlucidos y capas pictóricas de la Real Academia Nacional de Medicina (Madrid). (4818/0159) Dédalo Bienes Culturales, S.L.U. (Desconocido)
25/07/2022 31/12/2024 Next generation glycodrugs project (4553/0418) AMICUS THERAPEUTICS UK LIMITED (Desconocido)
06/05/2022 05/08/2022 Informe sobre los restos del tratamiento aplicado en la fachada de un edificio de ladrillo cara vista (4482/1058) Dédalo Bienes Culturales, S.L.U. (Desconocido)
19/04/2021 31/12/2024 Development of saccharide-based formulations for RNA therapies. (4090/0418) BioNTech RNA Pharmaceuticals GmbH (Desconocido)
05/10/2020 04/11/2020 Estudio de las Alteraciones Aparecidas en las Láminas de Cartón de unas Placas de Yeso Laminado Mediante la técnica FTIR con Dispositivo ATR (3949/1058) GEYSER GESTIÓN Y SERVICIOS TÉCNICOS A LA CONSTRUCCIÓN, S.L. (Desconocido)
01/09/2020 30/09/2020 Estudio y caracterización de materiales para la consolidación de la Fuente de los Pájaros y restauración de mosaicos del conjunto arqueológico de Itálica (3979/0751) Metis Conservación y Restauración (Desconocido)
01/06/2018 30/11/2019 Propiedades farmacocinéticas de la 6S-NBI-DGJ (3362/0418) AMICUS THERAPEUTICS UK LIMITED (Desconocido)
30/11/2017 29/01/2018 Estudio de materiales y evaluación de tratamientos de restauración en el Pabellón de Perú (Sevilla) (3203/0751) CONDISA, S.A.U. (Desconocido)
02/06/2017 01/11/2017 Controles para la Restauración de la estatua a Murillo de Sevilla: Ensayos, Diagnóstico y Pruebas de Protección (3105/0056) Dédalo Bienes Culturales, S.L.U. (Desconocido)
13/02/2017 31/03/2017 Estudio científico-técnico de la Piedra de la Fachada del Apeadero del Real Alcázar de Sevilla (2969/0056) Patronato del Real Alcázar (Desconocido)
30/05/2016 29/06/2016 Análisis del origen y efectos de la corrosión en estructura de acero. Museo Thyssen (2792/0751) INICIA SIGLO XXI, S.L. (Desconocido)
24/02/2016 31/12/2016 Desarrollo y terapia para las Mucopolisacaridosis y Síndromes Relacionados. (2736/0418) Asociación de las Mucopolisacaridosis y Síndromes Relacionados, MPS España (Desconocido)
24/02/2016 23/05/2016 Caracterización de muestras de mortero y pinturas de la Basílica de María Santísima de la Esperanza Macarena (Sevilla). (2762/0137) Real, Ilustre y Fervorosa Hermandad y Cofradía de Nazarenos de Nuestra Señora del Santo Rosario, Nuestro Padre Jesús de la Sentencia y María Santísima de la Esperanza Macarena (Desconocido)
04/05/2015 03/10/2015 Caracterización y estudio de propiedades de los materiales de revestimiento y de restitución y de los tratamientos de consolidación de la Parroquia de San Pablo (Sevilla). (2548/0159) ARCHIDIÓCESIS DE SEVILLA (Desconocido)
02/01/2015 01/05/2015 Estudio de la composición mineralógica de las pátinas y de la efectividad de los tratamientos de limpieza aplicados en el Cristo de las Mieles (Sevilla) (2476/0137) José León Calzado (Desconocido)
31/03/2014 31/07/2014 Caracterización de ladrillos vistos y morteros, alteraciones y estudio de la efectividad de conservación del Centro Comercial Plaza de Armas (Sevilla). (2203/0159) NECSA, Nuevos Espacios Comerciales, S.A. (Desconocido)
07/02/2014 06/02/2015 Desarrollo de chaperonas farmacológicas para el tratamiento de enfermedades de depósito lisosomal con afectación neurológica: Enfermedad de Gaucher y gangliosidosis GM1 (2175/0418) Colegio Oficial de Farmacéuticos de Sevilla (Desconocido)
01/02/2013 01/03/2013 Informe para comprobar la existencia de un tratamiento hidrofugante aplicado sobre los ladrillos de una fachada, en un edificio plurifamiliar de viviendas en Triana (Sevilla) (1781/0056) Comunidad de Propietarios Calle Virgen de la Amargura, 9 (Desconocido)
31/07/2012 30/07/2014 Asesoramiento y elaboración de informes científico-técnicos sobre caracterización y estudio de patologías de materiales de construcción en monumentos y edificios históricos. (1627/0159) Dédalo Bienes Culturales, S.L.U. (Desconocido)
01/07/2012 31/12/2013 Desarrollo experimental de procesos de transformación de Biomasa Lignocelulósica y otras fuentes de carbono en diversos bioproductos en Andalucía Sostenible. Bio-Andalus. (1612/0418) CANAGROSA (Desconocido)
19/04/2012 18/04/2014 Diagnóstico, asesoramiento y elaboración de informes científico-técnicos, sobre patologías en diversos materiales de construcción. (Inicio + pedido nº 1). (1545/0137) Cemosa Ingeniería y Control (Desconocido)
01/04/2012 31/03/2013 Investigación, preparación y posible utilización de derivados de ciclodextrinas como antagonistas de relajantes musculares. (1502/0418) Farmhispania, S.A. (Desconocido)
15/11/2010 31/12/2011 Desarrollo de Nuevos Productos Prebióticos a partir de Harinas de Arroz y Legumbres: Análisis Químico (0942/0418) HERBA RICEMILLS, S.L. (Desconocido)
10/01/2006 10/05/2006 Estudios de paramentos en el Monasterio de Santa Clara de Sevilla. Fase segunda (OG-023/06) J.B.A. Construcciones Bellido, S.L. (Desconocido)
21/12/2005 21/12/2007 Puesta a punto de métodos eficaces para la transformación de productos derivados de las industrias azucarera y láctea en oligosacáridos prebióticos (OG-150/05) Chirosep, S.A. (Desconocido)
28/01/2005 28/07/2005 Estudio exploratorio: Transformación de la lactosa en suero lácteo en galacto-gluco oligosacáridos con propiedades prebióticas (OG-030/05) Chirosep, S.A. (Desconocido)
19/01/2005 19/03/2005 Estudio sobre muestras de tablero de madera melaminizado (OG-019/05) Secotec (Desconocido)

Ayudas

Fecha de inicio Fecha de fin Denominación Agencia financiadora Importe concedido
01/01/2020 31/12/2020 Ayudas para el uso de los Servicios Generales de Investigación (PPI525/2020) Universidad de Sevilla (Local) 2.867,00 €
01/01/2020 31/12/2020 Ayudas para el uso de los Servicios Generales de Investigación (PPI518/2020) Universidad de Sevilla (Local) 701,00 €
01/01/2008 31/12/2009 Synthesis and biologicla evalutation of polyvalente glycosidase inhibitors as chemical chaperons for the treatment of lysosomal disorders (HU2007-0006) Ministerio de Educación y Ciencia (Nacional) 11.710,00 €

Infraestructura

Fecha de inicio Fecha de fin Denominación Agencia financiadora Importe concedido
01/01/2018 31/12/2020 Adquisición de un Espectrómetro Q-Exactive GC y periféricos para equipos existentes. Servicio de Espectrometría de Masas. CITIUS (EQC2018-004033-P) Ministerio de Ciencia, Innovación y Universidades - Agencia Estatal de Investigación (Nacional) 811.738,76 €

Patentes

Nº Solicitud Fecha Solicitud Fecha Concesión Nombre
P201232024 26/12/2012 23/04/2015 Utilización de derivados bicíclicos de 1-desoxigalactonojirimicina en la preparación de un medicamento para el tratamiento de enfermedades relacionadas con beta-enzimas galactosidasas lisosómicas mutantes humanas
EP22382898 29/09/2022 - Oligosaccharide complexes and uses
P201230804 25/05/2012 01/10/2014 Uso de un compuesto de fórmula (i) para la fabricación de un medicamento destinado al tratamiento de la enfermedad de gaucher, composición farmacéutica, un compuesto de fórmula (ib) y procedimiento de obtención.
EP23382023.2 13/01/2023 - Immunomodulatory thiourea and urea carbohydrate compounds and uses thereof
E04805527 24/11/2004 11/11/2009 Dimeros de ciclodextrinas y sus derivados, sus procedimientos de preparacion y su utilizacion en particular para la solubilizacion de sustancias farmacologicamente activas
US202063083293P 25/09/2020 - Glycosidase inhibitors and uses thereof
P200700675 07/03/2008 07/04/2009 Nuevos caramelos con elevado contenido en oligosacaridos prebioticos, procedimiento de preparacion y utilizacion
EP21382980 29/10/2021 - Multiantennary glycolipid mimetics
P200601282 11/05/2006 26/01/2009 Nuevos derivados de ciclodextrinas selectivamente fucionalizados en su cara secundaria, procedimiento de preparacion y utilizacion de los mismos.
EP21382981 29/10/2021 - Anti-inflammatory glycolipid mimetics
P201631484 18/11/2016 06/03/2019 Procedimiento de preparación de caramelos con elevado contenido en oligosacáridos prebióticos
EP21382958 22/10/2021 - Oligosaccharide compounds and complexes
P200900979 14/04/2009 01/09/2011 Ciclooligosacáridos anfifílicos policatiónicos y su uso como transportadores moleculares.
EP21383082 30/11/2021 - Oligosaccharide complexes and uses
P201530475 10/04/2015 23/02/2018 Composición para el tratamiento de enfermedades asociadas a trastornos lisosomales
EP22382517 30/05/2022 - Oligosaccharide complexes and uses
P200802988 22/10/2008 13/01/2011 Compuestos potenciadores de la actividad de glicosidasas mutantes
EP22382514 30/05/2022 - Oligosaccharide compounds and complexes
P201030867 04/06/2010 18/10/2012 Derivados sp2, imnoazúcar como inhibidores de las alfa-glicosidasas.
EP22382895 29/09/2022 - Oligosaccharide compounds and complexes