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Antonio Ayala Gómez

Catedrático de Universidad
aayala@us.es
Área de conocimiento: Bioquímica y Biología Molecular
Departamento: Bioquímica y Biología Molecular
Grupo: BIOQUIMICA DEL ENVEJECIMIENTO - BIO-158 (Universidad de Sevilla)
Centro mixto: Instituto de Biomedicina de Sevilla (IBIS)
Prog. doctorado: BIOLOGÍA MOLECULAR, BIOMEDICINA E INVESTIGACIÓN CLÍNICA

Investiga en

Tipo Año Título Fuente
Artículo2024 Comparing fermented food and vitamin E on exercise-mediated Nrf2/ARE activation in middle-aged/ elderly: A randomized, double-blind clinical study Functional Food Science
Artículo2024 Neutrophil-lymphocyte ratio and update conclusions from a 2-year double-blind rct testing fermented papaya preparation in healthy middle-aged/elderly subjects Functional Food Science
Capítulo2023 Anti-aging and rejuvenation based on stem cell therapy Emerging Anti-Aging Strategies
Capítulo2023 Basic pathways and targets for anti-aging intervention Anti-Aging Pharmacology
Artículo2023 Interim report from a 2-year double-blind RCT testing fermented papaya preparation on immune enhancement, endothelial health and QOL in elderly adults Functional Foods in Health and Disease
Revisión2023 Natural compounds as integrative therapy for liver protection against inflammatory and carcinogenic mechanisms: from induction to molecular biology advancement Current Molecular Medicine
Capítulo2023 Protein kinase modulation for anti-aging intervention Anti-Aging Pharmacology
Revisión2023 The Emerging Role of Senotherapy in Cancer: A Comprehensive Review Clinics and Practice
Artículo2022 Anti-inflammatory effect of Phytomarine R-L compound against lipopolysaccharide- induced pulmonary injury in BALB/c mice Functional Foods in Health and Disease
Artículo2022 The Neurokinin-1 Receptor Is Essential for the Viability of Human Glioma Cells: A Possible Target for Treating Glioblastoma BIOMED RESEARCH INTERNATIONAL
Capítulo2021 Gut stem cells: Interplay with immune system, microbiota, and aging Stem Cells and Aging
Capítulo2021 Hydroxytyrosol, olive oil, and use in aging Olives and olive oil in health and disease prevention (Second Edition)
Artículo2020 Effect of age and lipoperoxidation in rat and human adipose tissue-derived stem cells OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Artículo2020 Effects on goal directed behavior and habit in two animal models of Parkinson's disease NEUROBIOLOGY OF LEARNING AND MEMORY
Revisión2020 Rosmarinus officinalis l. (rosemary): an ancient plant with uses in personal healthcare and cosmetics Cosmetics
Artículo2019 Adipose-derived stem cells decreased microglia activation and protected dopaminergic loss in rat lipopolysaccharide model JOURNAL OF CELLULAR PHYSIOLOGY
Revisión2019 Advantages and disadvantages of apoptosis in the aging process ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Revisión2019 Dysregulation of the Hippo pathway signaling in aging and cancer PHARMACOLOGICAL RESEARCH
Artículo2019 Physical exercise and myokines APPROACHES TO AGING CONTROL
Artículo2019 Targeting pro-senescence mitogen activated protein kinase (Mapk) enzymes with bioactive natural compounds FOOD AND CHEMICAL TOXICOLOGY
Artículo2018 Cell tracking, survival, and differentiation capacity of adipose-derived stem cells after engraftment in rat tissue JOURNAL OF CELLULAR PHYSIOLOGY
Revisión2018 Role of Melatonin in the Inflammatory Process and its Therapeutic Potential CURRENT PHARMACEUTICAL DESIGN
Artículo2017 Aging and Oxidative Stress Decrease Pineal Elongation Factor 2: In Vivo Protective Effect of Melatonin in Young Rats Treated With Cumene Hydroperoxide JOURNAL OF CELLULAR BIOCHEMISTRY
Revisión2017 Application of Kinase Inhibitors for Anti-aging Intervention CURRENT PHARMACEUTICAL DESIGN
Artículo2017 Effect of VBC-1814/7J, a poly-phytocompound, on a non-infectious model of pharyngitis EXPERIMENTAL AND THERAPEUTIC MEDICINE
Artículo2017 Immunolocalization of Substance P and NK-1 Receptor in ADIPOSE Stem Cells JOURNAL OF CELLULAR BIOCHEMISTRY
Artículo2016 Beneficial effect of refined red palm oil on lipid peroxidation and monocyte tissue factor in HCV-related liver disease: a randomized controlled study HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
Artículo2016 Chronic stress alters the expression levels of longevity-related genes in the rat hippocampus NEUROCHEMISTRY INTERNATIONAL
Artículo2016 Hialuronic acid in sking aging Medicina Antienvejecimiento
Artículo2016 Time and dose dependent effects of oxidative stress induced by cumene hydroperoxide in neuronal excitability of rat motor cortex neurons NEUROTOXICOLOGY
Artículo2015 Advanced therapy medicinal products: Gene therapy Pharmaceuticals Policy and Law
Revisión2015 Endogenous opioid. A review APPROACHES TO AGING CONTROL
Capítulo2015 Medio ambiente y envejecimiento Innovación en la gestión e investigación ambiental
Artículo2015 Oxidative stress induced by cumene hydroperoxide evokes changes in neuronal excitability of rat motor cortex neurons NEUROSCIENCE
Artículo2015 Treatment with mesenchymal stem cells in an animal model of parkinson's disease APPROACHES TO AGING CONTROL
Artículo2014 A Double-Blind, RCT Testing Beneficial Modulation of BDNF in Middle-Aged, Life Style-Stressed Subjects: A Clue to Brain Protection? JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
Artículo2014 Chronic stress as a risk factor for Alzheimer's disease REVIEWS IN THE NEUROSCIENCES
Ponencia2014 Effects of aging and oxidative stress on elongation factor-2 in the pineal gland and its protection by melatonin ACTA PHYSIOLOGICA
Artículo2014 Elongation factor 2 diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative Stress conditions FREE RADICAL BIOLOGY AND MEDICINE
Artículo2014 Experimental Evidence of Effectiveness of VBC-1814/7J, a Poly-Phytocompound, on Inflammatory and Virological Changes in an Influenza-Model. International Medical Journal
Revisión2014 Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Artículo2013 Molecular control of the amount, subcellular location, and activity state of translation elongation factor 2 in neurons experiencing stress FREE RADICAL BIOLOGY AND MEDICINE
Capítulo2012 Assessment of the general oxidant status of individuals in non-invasive samples Oxidative Stress - Molecular Mechanisms and Biological Effects
Artículo2012 Folic acid supplementation: some practical aspects APPROACHES TO AGING CONTROL
Artículo2012 In vitro and in vivo protection by melatonin against the decline of elongation factor-2 caused by lipid peroxidation: preservation of protein synthesis JOURNAL OF PINEAL RESEARCH
Artículo2012 Potential use of adipose tissue stem cells in the control of aging APPROACHES TO AGING CONTROL
Artículo2011 Effect of aging and oxidative stress on elongation factor-2 in hypothalamus and hypophysis MECHANISMS OF AGEING AND DEVELOPMENT
Artículo2010 Comparative Study of the in Vitro Protective Effects of Several Antioxidants on Elongation Factor 2 under Oxidative Stress Conditions BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Artículo2010 Use of haptoglobin and transthyretin as potential biomarkers for the preclinical diagnosis of Parkinson's disease NEUROCHEMISTRY INTERNATIONAL
Artículo2009 Adduct formation of 4-hydroxynonenal and malondialdehyde with elongation factor-2 in vitro and in vivo FREE RADICAL BIOLOGY AND MEDICINE
Artículo2009 Anti-aging medicine. What is that? APPROACHES TO AGING CONTROL
Artículo2009 Effects of thermo-oxidised oils on lipid peroxidation in experimental animals NUTRICION HOSPITALARIA
Ponencia2009 Observations on the Brain Development of the Sturgeon Acipenser naccarii BIOLOGY, CONSERVATION AND SUSTAINABLE DEVELOPMENT OF STURGEONS
Artículo2007 'In vitro' protective effect of a hydrophilic vitamin e analogue on the decrease in levels of elongation factor 2 in conditions of oxidative stress GERONTOLOGY
Artículo2007 A preliminary analysis of within-subject variation in human serum oxidative stress parameters as a function of time REJUVENATION RESEARCH
Revisión2007 Mitochondrial toxins and neurodegenerative diseases FRONTIERS IN BIOSCIENCE-LANDMARK
Artículo2007 Proteomic identification of biomarkers in the cerebrospinal fluid in a rat model of nigrostriatal dopaminergic degeneration JOURNAL OF NEUROSCIENCE RESEARCH
Artículo2006 "In vitro" effect of lipid peroxidation metabolites on elongation factor-2 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Artículo2006 Correlation between circulating biomarkers of oxidative stress of maternal and umbilical cord blood at birth FREE RADICAL RESEARCH
Artículo2006 Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: a cohort study CRITICAL CARE
Artículo2006 Stress increases vulnerability to inflammation in the rat prefrontal cortex JOURNAL OF NEUROSCIENCE
Artículo2005 Effects of short-term supplementation with folic acid on different oxidative stress parameters in patients with hypertension BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Artículo2004 Do the serum oxidative stress biomarkers provide a reasonable index of the general oxidative stress status? BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Artículo2003 "In vitro" effect of cumene hydroperoxide on hepatic elongation factor-2 and its protection by melatonin BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Artículo2003 Comparison of methods for sample preparation of individual rat cerebrospinal fluid samples prior to two-dimensional polyacrylamide gel electrophoresis BIOTECHNOLOGY LETTERS
Artículo2003 Effect of prenatal exposure to ethanol on hepatic elongation factor-2 and proteome in 21 D old rats: Protective effect of folic acid FREE RADICAL BIOLOGY AND MEDICINE
Artículo2003 Semichronic inhibition of glutathione reductase promotes oxidative damage to proteins and induces both transcription and translation of tyrosine hydroxylase in the nigrostriatal system FREE RADICAL RESEARCH
Artículo2002 Decrease of 1-methyl-1,2,3,4-tetrahydroisoquinoline synthesizing enzyme activity in the brain areas of aged rat BRAIN RESEARCH
Artículo2002 Impairment of mineralocorticoid receptor (MR)-dependent biological response by oxidative stress and aging - Correlation with post-translational modification of MR and decreased ADP-ribosylatable level of elongation factor 2 in kidney cells JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2001 Protective effect of folic acid against oxidative stress produced in 21-day postpartum rats by maternal-ethanol chronic consumption during pregnancy and lactation period FREE RADICAL RESEARCH
Artículo2000 Protective effect of melatonin against the 1-methyl-4-phenylpyridinium-induced inhibition of Complex I of the mitochondrial respiratory chain JOURNAL OF PINEAL RESEARCH
Artículo2000 The endogenous amine 1-methyl-1,2,3,4-tetrahydroisoquinoline prevents the inhibition of complex I of the respiratory chain produced by MPP+ JOURNAL OF NEUROCHEMISTRY
Artículo1999 Effects of aging on the various steps of protein synthesis: Fragmentation of elongation factor 2 FREE RADICAL BIOLOGY AND MEDICINE
Artículo1999 Induced mono-(ADP)-ribosylation of rat liver cytosolic proteins by lipid peroxidant agents FREE RADICAL BIOLOGY AND MEDICINE
Artículo1998 Use of Rotofor preparative isoelectrofocusing cell in protein purification procedure Applied Biochemistry and Biotechnology
Artículo1997 Low selenium diet increases the dopamine turnover in prefrontal cortex of the rat NEUROCHEMISTRY INTERNATIONAL
Artículo1997 Preferential use of less toxic detoxification pathways by long-lived species ARCHIVES OF GERONTOLOGY AND GERIATRICS
Artículo1997 Use of electrophoretic titration curves in the purification of a beta-1-3 glucanase from Oerskovia xanthineolytica BIOTECHNOLOGY TECHNIQUES
Artículo1996 Acción protectora del deprenilo frente a los daños oxidativos cerebrales producidos durante el envejecimiento Revista Española de Geriatría y Gerontología
Artículo1996 Changes in superoxide dismutase activity in liver and lung of old rats FREE RADICAL RESEARCH
Artículo1996 Comparison of 5-hydroxy-2-aminovaleric acid with carbonyl groups content as a marker of oxidized protein in human and mouse liver tissues. FREE RADICAL BIOLOGY AND MEDICINE
Artículo1996 Effect of oxidative stress, produced by cumene hydroperoxide, on the various steps of protein synthesis - Modifications of elongation factor-2 JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1996 Optimización de la I+D en la industria farmaceútica Industria Farmacéutica
Artículo1996 Oxidative inactivation of tyrosine hydroxylase in substantia nigra of aged rat FREE RADICAL BIOLOGY AND MEDICINE
Artículo1996 The utilization of 5-Hydroxy-2-Amino valeric acid as a specific marker of oxidized arginine and proline residues in proteins. FREE RADICAL BIOLOGY AND MEDICINE
Artículo1995 A convenient procedure for quantitative-analysis of stained or immunostained blotting membranes by densitometry BIOTECHNOLOGY TECHNIQUES
Artículo1995 Changes in the histidine-residues of cu/zn superoxide-dismutase during aging FEBS LETTERS
Artículo1995 Increase in dopamine turnover and tyrosine-hydroxylase enzyme in hippocampus of rats fed on low selenium diet JOURNAL OF NEUROSCIENCE RESEARCH
Artículo1995 One-step electroblotting of 2- to 100-kDa proteins onto a PVDF membrane Applied Biochemistry and Biotechnology
Nota1994 Reduction of 1-methyl 1,2,3,4-tetrahydroisoquinoline level in substantia-nigra of the aged rat BRAIN RESEARCH
Artículo1993 Direct quantitative determination of peptides and proteins in PVDF transfer membrane using a computing densitometer. PEPTIDE RESEARCH
Artículo1993 Protective effect of deprenyl against 1-methyl-4-phenylpyridinium neurotoxicity in rat striatum Neuroscience Letters
Artículo1991 Involvement of diminution of glutathione, produced by deficiency of methionine in the diet, in the elevation of malic enzyme level in rat-liver BIOCHIMICA ET BIOPHYSICA ACTA
Artículo1991 Relationship between enzymatic-activity loss and posttranslational protein modification in aging ARCHIVES OF GERONTOLOGY AND GERIATRICS
Artículo1991 The role of NADPH in the regulation of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in rat adipose tissue MOLECULAR AND CELLULAR BIOCHEMISTRY
Artículo1990 Possible involvement of NADPH requirement in regulation of Glucose-6-Phosphate and 6-Phosphogluconate dehydrogenase levels in rat liver MOLECULAR AND CELLULAR BIOCHEMISTRY
Artículo1989 Implication of lysine residues in the loss of enzimatic activity in rat liver 6-phosphogluyconate dehydrogenase found in aging JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1988 Possible involvement of histidine residues in the loss of enzymatic activity of rat liver malic enzyme during aging JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1987 Measurement ex-vivo of the inhibition of fatty acids biosynthesis by bezafibrate administration in different rat tissues. JOURNAL OF PHARMACY AND PHARMACOLOGY
Artículo1986 Malic enzyme levels are increased by the activation of nadph-consuming pathways - detoxification processes FEBS LETTERS

Tesis dirigidas/tutorizadas:9
Fecha lectura Título Rol
22/01/2016 Estudio de la viabilidad y diferenciación de las células madre mesenquimales de tejido adiposo en condiciones de estrés oxidativo y envejecimiento. Posibilidad de su uso terapéutico e influencia del factor de elongación 2 Director/a
26/06/2015 ABORDAJE DE LA ANSIEDAD OBSESIVA: ESTUDIO ENTRE DIFERENTES GRUPOS CLÍNICOS DE TRATAMIENTO. EL TRASTORNO OBSESIVO COMPULSIVO: UN ANÁLISIS COMPARATIVO DE LOS RESULTADOS A LOS TRATAMIENTOS PARADIGMÁTICOS COGNITIVO Director/a
29/09/2014 Efecto del tratamiento con metformina en el sistema dopaminérgico nigroestriado. Posible implicación en la enfermedad de Parkinson Director/a
12/05/2011 ESTUDIO DE LA INTERACCIÓN DEL LITIO CON MOLÉCULAS QUE PARTICIPAN EN LA TRANSMISIÓN DE LA SEÑAL SINÁPTICA: UNA APROXIMACIÓN A LAS ALTERACIONES PSICOPATOLÓGICAS Y NEURODEGENERATIVAS Director/a
13/07/2007 EFECTO DE COMPUESTOS ANTIOXIDANTES Y PROTECTORES SOBRE LOS NIVELES DEL FACTOR DE ELONGACIÓN-2 EN CONDICIONES DE ESTRÉS OXIDATIVO Director/a
16/12/2005 ESTUDIO DE LOS EFECTOS PRODUCIDOS POR LA ADMINISTRACIÓN CRÓNICA DE MANGANESO: IMPLICACIÓN DE LA INGESTA DE HIERRO Director/a
12/11/2004 ESTUDIO PROTEÓMICO Y DE MARCADORES DE OXIDACIÓN EN SITUACIONES PATOLÓGICAS RELACIONADAS CON EL ESTRÉS OXIDATIVO: EFECTO PROTECTOR DEL ÁCIDO FÓLICO Y DEL GLUTATION Director/a
20/12/2001 EFECTO PROTECTOR DE COMPUESTOS ANTIOXIDANTES Y NEUROPROTECTORES (MELATONINA Y l-METILTETRAHIDROISOQUINOLINA) SOBRE LA DISFUNCIÓN MITOCONDRIAL, SÍNTESIS DE PROTEINAS Y ESTRÉS OXIDATIVO Director/a
12/12/1997 Sintesis de proteinas y envejecimiento: papel de los radicales libres Director/a

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2004 31/03/2007 Responsable Estudio del mecanismo de inhibición de la síntesis de proteínas por el envejecimiento y el estrés oxidativo y prevención de esta inhibición mediante el uso de compuestos antioxidantes y protectores (PI031233) Ministerio de Sanidad y Consumo (Instituto de Salud Carlos III) (Nacional)
01/10/2006 30/09/2009 Responsable Influencia del mantenimiento de la síntesis de proteínas durante el envejecimiento en el aumento del plazo de vida causado por la restricción claorica: importancia del factor de elongación 2 (BFU2006-06517) Ministerio de Educación y Ciencia (Nacional)
01/01/2010 31/12/2010 Responsable Implicación de las interacciones de las rutas que aumentan la vida media y la supervivencia celular con el factor de elongación 2 en el mantenimiento de la síntesis de proteínas durante el envejecimiento (BFU2009-12307) Ministerio de Ciencia e Innovación (Nacional)
01/01/2011 31/12/2013 Responsable Significado Biológico de la Integración de los distintos Mecanismos de Regulación del Factor de Elongación-2 en Condiciones de Estrés Celular y Envejecimiento (BFU2010-20882) Ministerio de Ciencia e Innovación (Nacional)
03/03/2011 03/03/2015 Investigador/a Estudio de los Cambios que Experimentan con el Envejecimiento las Rutas que Promueven la Supervivencia Celular y la Inflamación Cerebral: Modulación de las Mismas para Conseguir un Envejecimiento Saludable y Minimizar la Neurodegeneración (P09-CTS-5244) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
15/03/2011 30/04/2016 Investigador/a Estudio de los Mecanismos Moleculares que Regulan la Inflamación Cerebral y la Longevidad. Diseño de Estrategias Farmacológicas Encaminadas a Minimizar el Daño Neuronal Asociado a la Inflamación Cerebral en Modelos Animales de Enfermedades Neurodegenerativas (P10-CTS-6494) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
28/12/2001 27/12/2004 Investigador/a Degeneración del sistema dopaminérgico negro-estriado: marcadores de la velocidad de degeneración (Posible diagnóstico del estadio subclínico de la enfermedad de Parkinson); estudio de los mecanismos de supervivencia producido por GDNF y deprenilo (BFI2001-3600) Ministerio de Ciencia y Tecnología (Nacional)
13/12/2004 13/12/2007 Investigador/a Estudio de la influencia de la dopamina y el estrés en los procesos inflamatorios y degenerativos inducidos por la inyección de lipopolisacárido en el SNC (SAF2004-06601) Ministerio de Ciencia y Tecnología (Nacional)
01/03/2006 28/02/2009 Investigador/a La enfermedad de Parkinson: Diagnostico en estado subclinico (EXC/2005/CTS-1014) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
01/09/2023 31/08/2027 Responsable Mecanismos y uso del hidroxitirosol e inhibidores del factor de elongación-2 para mejorar sinergeticamente la respuesta inmune antitumoral en carcinomas de células escamosas (PID2022-141577OB-I00) Ministerio de Ciencia e Innovación (Nacional)

Patentes

Nº Solicitud Fecha Solicitud Fecha Concesión Nombre
P201500766 05/07/2016 24/10/2019 Kit y método de cuantificación de la toxicidad en neuronas de la corteza cerebral para la detección de enfermedades neurodegenerativas