CBSCS - Prisma - Unidad de Bibliometría

FISIOPATOLOGÍA DE CÉLULAS MADRE NEURALES - CTS-007 (CBSCS)

Tipo de colectivo: Grupo de investigación
Estado: Grupo definitivo
Ámbito: Andalucía
Instituciones: Universidad de Sevilla
Fecha de creación: 21/01/2011

Investiga en

Tipo Año Título Fuente
Artículo2024 Efecto de la hipoxia intermitente crónica en la reorganización celular del cuerpo carotídeo Revista Española de Patología Torácica
Artículo2023 Analysis of serial neuroblastoma PDX passages in mice allows the identification of new mediators of neuroblastoma aggressiveness INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2023 Non-metabolic functions of phosphofructokinase-1 orchestrate tumor cellular invasion and genome maintenance under bevacizumab therapy NEURO-ONCOLOGY
Artículo2023 Protection and repair of the nigrostriatal pathway with stem-cell-derived carotid body glomus cell transplants in chronic MPTP Parkinsonian model INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2023 Rearrangement of cell types in the rat carotid body neurogenic niche induced by chronic intermittent hypoxia JOURNAL OF PHYSIOLOGY-LONDON
Artículo2023 The adult carotid body: a germinal niche at the service of physiology Advances in experimental medicine and biology
Artículo2022 A protocol to enrich in undifferentiated cells from neuroblastoma tumor tissue samples and cell lines STAR Protocols
Artículo2022 CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway. NATURE COMMUNICATIONS
Artículo2022 Therapeutic opportunities of disrupting genome integrity in adult diffuse glioma Biomedicines
Artículo2021 A high-affinity peptide ligand targeting syntenin inhibits glioblastoma JOURNAL OF MEDICINAL CHEMISTRY
Editorial2021 Non-canonical kinases and substrates in cancer progression CANCERS
Letter2020 A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity CELL DISCOVERY
Corrección2020 Corrigendum to ‘CD44-high neural crest stem-like cells are associated with tumour aggressiveness and poor survival in neuroblastoma tumours’ (EBioMedicine (2019) 49 (82–95), (S235239641930711X), (10.1016/j.ebiom.2019.10.041)) EBIOMEDICINE
Revisión2020 Hypoxia in the initiation and progression of neuroblastoma tumours INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2020 Identification of VRK1 as a new neuroblastoma tumor progression marker regulating cell proliferation CANCERS
Revisión2020 Neurotransmitter modulation of carotid body germinal niche INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Nota2020 Response to “High CD44 expression is not a prognosis marker in patients with high-risk neuroblastoma” EBIOMEDICINE
Artículo2020 SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells NATURE COMMUNICATIONS
Corrección2019 Author Correction: Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations (Nature, (2016), 540, 7632, (270-275), 10.1038/nature20592) NATURE
Artículo2019 CD44-high neural crest stem-like cells are associated with tumour aggressiveness and poor survival in neuroblastoma tumours EBIOMEDICINE
Resumen congreso2019 In vivo partial reprogramming of parenchymal glia into neural stem cells GLIA
Artículo2019 Loss of postnatal quiescence of neural stem cells through mTOR activation upon genetic removal of cysteine string protein-alpha PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Capítulo2019 Progenitor Cell Heterogeneity in the Adult Carotid Body Germinal Niche Stem Cells Heterogeneity - Novel Concepts
Revisión2019 The carotid body: a physiologically relevant germinal niche in the adult peripheral nervous system CELLULAR AND MOLECULAR LIFE SCIENCES
Revisión2018 Elixir of life thwarting aging with regenerative reprogramming CIRCULATION RESEARCH
Artículo2018 Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia EMBO REPORTS
Resumen congreso2018 Identification of novel radiosensitizers in glioblastoma cancer stem-like cells NEURO-ONCOLOGY
Resumen congreso2018 Spt6 regulates transcription by stabilizing RNA POL II and so drives glioblastoma cancer stem-like cell maintenance NEURO-ONCOLOGY
Revisión2018 The RhoB small GTPase in physiology and disease Small GTPases
Resumen congreso2018 The role of RAD52 in genomic instability and therapeutic resistance of malignant gliomas NEURO-ONCOLOGY
Artículo2017 Association of high microvessel alpha(v)beta(3) and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126 ONCOTARGET
Artículo2017 CCAAT/Enhancer binding protein beta silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease Scientific reports
Artículo2017 Interspecies chimerism with mammalian pluripotent stem cells CELL
Artículo2017 Neural crest derived progenitor cells contribute to tumor stroma and aggressiveness in stage 4/M neuroblastoma ONCOTARGET
Artículo2017 Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body CELL REPORTS
Artículo2017 Role and therapeutic potential of vascular stem/progenitor cells in pathological neovascularisation during chronic portal hypertension GUT
Artículo2017 The atheroma plaque secretome stimulates the mobilization of endothelial progenitor cells ex vivo JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Revisión2016 Carotid body oxygen sensing and adaptation to hypoxia PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Artículo2016 Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBP beta JOURNAL OF NEUROINFLAMMATION
Artículo2016 Gene expression profiling supports the neural crest origin of adult rodent carotid body stem cells and identifies CD10 as a marker for mesectoderm-committed progenitors STEM CELLS
Artículo2016 Generation of human organs in pigs via interspecies blastocyst complementation Reproduction in Domestic Animals
Artículo2016 In vivo amelioration of age-associated hallmarks by partial reprogramming CELL
Resumen congreso2016 Inhibition of neuroblastoma growth by the thiadiazolidinone compound TDZD-8 EUROPEAN JOURNAL OF CANCER
Revisión2016 Mature neurons modulate neurogenesis through chemical signals acting on neural stem cells DEVELOPMENT GROWTH & DIFFERENTIATION
Artículo2016 Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations NATURE
Resumen congreso2016 Neural crest derived progenitors give rise to tumor stroma and contribute to aggressiveness in high-risk neuroblastoma EUROPEAN JOURNAL OF CANCER
Artículo2016 Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation Scientific reports
Revisión2016 Oxygen sensing by the carotid body: mechanisms and role in adaptation to hypoxia AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Revisión2016 Oxygen-sensing by arterial chemoreceptors: mechanisms and medical translation MOLECULAR ASPECTS OF MEDICINE
Artículo2015 CCAAT/enhancer binding protein beta directly regulates the expression of the complement component 3 gene in neural cells: implications for the pro-inflammatory effects of this transcription factor JOURNAL OF NEUROINFLAMMATION
Artículo2015 CCAAT/Enhancer binding protein beta induces motility and invasion of glioblastoma cells through transcriptional regulation of the calcium binding protein S100A4 ONCOTARGET
Revisión2015 Neurotrophic properties, chemosensory responses and neurogenic niche of the human carotid body Arterial chemoreceptors in physiology and pathophysiology
Artículo2015 Resistance of glia-like central and peripheral neural stem cells to genetically induced mitochondrial dysfunctiondifferential effects on neurogenesis EMBO REPORTS
Artículo2015 Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival HYPOXIA
Artículo2015 Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice NEUROBIOLOGY OF AGING
Artículo2015 The Rho GTPase RhoB regulates cadherin expression and epithelial cell-cell interaction CELL COMMUNICATION AND SIGNALING
Artículo2014 An O-2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia CELL
Artículo2013 Cellular properties and chemosensory responses of the human carotid body JOURNAL OF PHYSIOLOGY-LONDON
Artículo2013 Estudio de expresión de marcadores de células madre neurales en neuroblastoma y correlación con factores pronóstico Cirugía Pediátrica
Artículo2012 Cdc42 promotes transendothelial migration of cancer cells through beta 1 integrin JOURNAL OF CELL BIOLOGY
Artículo2012 NEURAL STEM CELLS AND TRANSPLANTATION STUDIES IN PARKINSON'S DISEASE Advances in experimental medicine and biology
Artículo2012 RhoB regulates cell migration through altered focal adhesion dynamics OPEN BIOLOGY
Artículo2012 The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury JOURNAL OF NEUROCHEMISTRY
Resumen congreso2012 Vascular niche factor regulate rodent adult carotid body stem cell activity FEBS JOURNAL
Capítulo2011 A pathophysiological view of the neural stem cell niche Stem Cell, Regenerative Medicine and Cancer
Artículo2011 Decreased CCAAT/enhancer binding protein β expression inhibits the growth of glioblastoma cells NEUROSCIENCE
Artículo2011 RhoA and RhoC have distinct roles in migration and invasion by acting through different targets JOURNAL OF CELL BIOLOGY
Artículo2011 Role of C/EBP beta Transcription Factor in Adult Hippocampal Neurogenesis PLOS ONE
Revisión2011 Roles of VRK1 as a new player in the control of biological processes required for cell division CELLULAR SIGNALLING
Artículo2010 Inhibition of Glioblastoma Growth by the Thiadiazolidinone Compound TDZD-8 PLOS ONE
Revisión2010 The carotid body, a neurogenic niche in the adult peripheral nervous system ARCHIVES ITALIENNES DE BIOLOGIE
Artículo2009 Oxygen Sensing in the Carotid Body ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Revisión2009 The neurogenic niche in the carotid body and its applicability to antiparkinsonian cell therapy JOURNAL OF NEURAL TRANSMISSION
Artículo2008 Cancer stem cells and brain tumors CLINICAL & TRANSLATIONAL ONCOLOGY
Revisión2008 Carotid body oxygen sensing EUROPEAN RESPIRATORY JOURNAL
Artículo2008 Characterisation of tumoral markers correlated with ErbB2 (HER2/Neu) overexpression and metastasis in breast cancer PROTEOMICS CLINICAL APPLICATIONS
Revisión2008 Rho GTPases in cancer cell biology FEBS LETTERS
Artículo2008 The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53 PLOS ONE
Artículo2007 Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body CELL
Artículo2007 Identification of a human epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Revisión2007 Snapshot: Rho family GTPases CELL
Artículo2007 Understanding our own neural stem cells in situ: can we benefit from them? FRONTIERS IN BIOSCIENCE-LANDMARK
Artículo2006 Increasing p16(INK4a) expression decreases forebrain progenitors and neurogenesis during ageing NATURE
Artículo2006 p53 downregulates its activating vaccinia-related kinase 1 (VRK1) forming a new autoregulatory loop MOLECULAR AND CELLULAR BIOLOGY
Artículo2006 Rac1 and Rac2 regulate macrophage morphology but are not essential for migration JOURNAL OF CELL SCIENCE
Artículo2006 Subcellular localization of vaccinia-related kinase 2 (VRK2) isoforms determines their different effects on p53 stability in tumour cell lines FEBS JOURNAL
Artículo2006 VRK1 Signaling pathway in the context of the proliferation phenotype in Head and Neck squamous cell carcinoma MOLECULAR CANCER RESEARCH
Artículo2005 Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16(Ink4a) and P19(Arf) senescence pathways GENES & DEVELOPMENT
Ponencia2005 Stem cell self-renewal and aging reflect a balance between repression and age-related activation of the INK4A and ARF senescence pathways. DEVELOPMENTAL BIOLOGY
Ponencia2005 Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors MOLECULAR APPROACHES TO CONTROLLING CANCER
Artículo2004 c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK) ONCOGENE
Artículo2004 Combined oxygen and glucose sensing in the carotid body UNDERSEA & HYPERBARIC MEDICINE
Ponencia2004 Combined oxygen and glucose sensing in the carotid body UNDERSEA & HYPERBARIC MEDICINE
Revisión2004 Diverse mechanisms regulate stem cell self-renewal CURRENT OPINION IN CELL BIOLOGY
Artículo2004 Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2004 p53 Stabilization and accumulation induced by human vaccinia-related kinase 1 MOLECULAR AND CELLULAR BIOLOGY
Artículo2004 The vaccinia virus B1R kinase induces p53 downregulation by and Mdm2-dependent mechanism Virology
Revisión2003 Applying the principles of stem-cell biology to cancer Nature Reviews. Cancer
Artículo2003 Autotransplantation of human carotid body cell aggregates for treatment of Parkinson's disease Neurosurgery
Artículo2003 Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation NATURE
Capítulo2003 Carotid body thin slices: New answers for old questions Oxygen Sensing: Responses and Adaption to Hypoxia
Artículo2003 Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development FEBS LETTERS
Artículo2003 Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes NATURE
Artículo2003 Glucose sensing cells in the carotid body Advances in experimental medicine and biology
Artículo2003 Hirschsprung disease is linked to defects in neural crest stem cell function SCIENCE
Artículo2003 Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells JOURNAL OF PHYSIOLOGY-LONDON
Artículo2003 Studies on glomus cell sensitivity to hypoxia in carotid body slices Advances in experimental medicine and biology
Artículo2003 Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats JOURNAL OF NEUROSCIENCE
Artículo2003 Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats JOURNAL OF NEUROSCIENCE
Artículo2002 Carotid body thin slices: responses of glomus cells to hypoxia and K+-channel blockers RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Artículo2002 Dopaminergic cells of the carotid body: Physiological significance and possible therapeutic applications in Parkinson's disease BRAIN RESEARCH BULLETIN
Ponencia2002 Glucose Sensing Cells in the Carotid Body Advances in experimental medicine and biology
Artículo2002 Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Artículo2002 Low glucose-sensing cells in the carotid body NATURE NEUROSCIENCE
Artículo2002 Studies on glomus cell sensitivity to hypoxia in carotid body slices Advances in experimental medicine and biology
Revisión2001 Cellular mechanisms of oxygen sensing ANNUAL REVIEW OF PHYSIOLOGY
Ponencia2001 Transplantation of carotid body cell aggregates in patients with Parkinson's disease: a pilot study. PARKINSONISM & RELATED DISORDERS
Artículo2000 Collapse of conductance is prevented by a glutamate residue conserved in voltage-dependent K+ channels JOURNAL OF GENERAL PHYSIOLOGY
Artículo2000 Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo1999 K+ and Ca2+ channel activity and cytosolic [Ca2+] in oxygen-sensing tissues RESPIRATION PHYSIOLOGY
Artículo1999 Trimeric G proteins modulate the dynamic interaction of PKAII with the Golgi complex JOURNAL OF CELL SCIENCE
Ponencia1998 Studies on native and recombinant potassium channel modulation by hypoxia in cell lines. EUROPEAN JOURNAL OF NEUROSCIENCE

Proyectos de Investigación

Fecha de inicio Fecha de fin Denominación Agencia financiadora Importe concedido
01/04/2024 31/03/2026 Estudio del efecto de la reprogramación parcial sobre la fisiología de los astrocitos y su potencial impacto en la homeostasis cerebral y la capacidad cognitiva (CNS2023-144411) Ministerio de Ciencia e Innovación (Nacional) 199.880,00 €
01/09/2023 31/08/2026 Descifrando los mecanismos de Radiorresistencia: Interacción funcional entre la transcripción y el estrés replicativo en las jerarquías celulares del glioblastoma (PID2022-136824OA-I00) Ministerio de Ciencia e Innovación (Nacional) 175.000,00 €
01/09/2023 31/08/2026 Revelando señalización específica en células indiferenciadas de la cresta neural: nuevas oportunidades de tratamiento para el neuroblastoma agresivo (PID2022-142424OB-I00) Ministerio de Ciencia e Innovación (Nacional) 212.500,00 €
16/12/2020 15/12/2023 Ingenieria de la neurogenesis aplicada a la regeneración del tejido cerebral (P18-RTJ-1088) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico) 190.900,00 €
01/09/2020 31/08/2022 Ingeniería de la neurogénesis y regeneración cerebral: desarrollo de una tecnología basada en la reprogramación celular para activar la formación de nuevas neuronas en el cerebro adulto. (US-1262881) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico) 30.000,00 €
01/06/2020 31/12/2023 Heterogeneidad Celular Derivada de la Cresta Neural Simpatoadrenal: Implicaciones en la Progresión y el Tratamiento de los Neuroblastomas (PID2019-110817RB-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional) 189.970,00 €
01/02/2020 30/04/2022 Fisiopatología Celular y Molecular de los Neuroblastomas Agresivos (US-1262985) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico) 89.700,00 €
01/01/2020 31/12/2022 Fisiopatología Celular y Molecular de los Neuroblastomas Agresivos (P18-RT-3151) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico) 140.352,00 €
30/12/2016 29/12/2020 Fisiopatología de Células Madre Derivadas de la Cresta Neural (SAF2016-80412-P) Ministerio de Economía y Competitividad (Nacional) 157.300,00 €
01/01/2014 31/12/2017 Fisiopatología de Células Madre Derivadas de la Cresta Neural (SAF2013-48535-P) Ministerio de Economía y Competitividad (Nacional) 302.500,00 €
01/11/2012 01/11/2015 Fisiopatología de células madre cancerosas en neuroblastoma pediátrico (CONVCL2012/008) Fundación AECC (Nacional) 150.000,00 €
01/01/2012 01/01/2014 Convenio de colaboración en materia de apoyo a la transferencia tecnológica en el campo de la biotecnología (CVFB12/005) Fundación Marcelino Botín (Nacional) 125.000,00 €
01/11/2010 31/10/2015 Physiology of the adult carotid body stem cell niche 260964 (260964) Comisión Europea (Europeo) 1.476.000,00 €
01/01/2010 31/12/2012 Regulación de la fisiología de las células madre adultas específicas del cuerpo carotídeo (SAF2009-11440) Ministerio de Ciencia e Innovación (Nacional) 163.350,00 €
01/01/2007 31/12/2012 Sensibilidad al oxígeno y neurodegeneración (CONFMB-001/2006) Fundación Marcelino Botín (Nacional) 220.000,00 €
01/10/2006 30/09/2009 Sensibilidad al oxígeno y neurodegeneración (SAF2006-08311) Ministerio de Educación y Ciencia (Nacional) 393.250,00 €
01/11/2005 31/10/2009 Network of European Neuroscience Institutes (ENINET) (LSHM-CT-2005-019063) Commission of the European Communities (Research Directorate-General) (Europeo) 68.250,00 €

Contratos

Fecha de inicio Fecha de fin Denominación Agencia financiadora Importe concedido
11/01/2022 30/06/2023 High-throughput screening for novel rejuvenation factors (4368/1142) YouthBio Therapeutics Inc. (Desconocido)
23/01/2015 10/04/2015 PSTEMCELLS (2511/0782) SGS ICS IBÉRICA, S.A. (Desconocido)

Ayudas

Fecha de inicio Fecha de fin Denominación Agencia financiadora Importe concedido
11/11/2010 15/03/2011 Estudio de validación del uso de micro-arrays basados en sensores impedimétricos para la caracterización de muestras tumorales en base a la detección de la presencia de moléculas superficiales mediante reacciones antigeno-anticuerpo (OTR2010-CT21) Universidad de Sevilla (Oficina de Transferencia de Resultados de Investigación) (Local) 1.500,00 €
16/06/2010 19/06/2010 International Society For Stem Cell Research (ISSCR 8th Annual Meeting) (PP2010-06-016) Universidad de Sevilla (Local) 600,00 €
05/05/2010 30/09/2010 Physiology of the adult carotid body stem cell niche (OTR2010-PC09) Universidad de Sevilla (Oficina de Transferencia de Resultados de Investigación) (Local) 2.000,00 €

Redes de Investigación

Fecha de inicio Fecha de fin Denominación Agencia financiadora Importe concedido
01/01/2013 31/12/2017 Redes temáticas de investigación cooperativa en salud (RD12/0019/0033) Ministerio de Economía y Competitividad (Instituto de Carlos III) (Nacional) 74.175,00 €

Patentes

Nº Solicitud Fecha Solicitud Fecha Concesión Nombre
P200702167 02/08/2007 23/06/2010 Células madre derivadas del cuerpo carotideo y usos de las mismas