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Alfredo Corell Almuzara

Catedrático de Universidad (Pza. V.)
alfredo.corell@us.es
Área de conocimiento: Inmunología
Departamento: Bioquímica Médica y Biología Molecular e Inmunología
Grupo: InmunoNutrición e InmunoMetabolismo - CTS-1074 (Universidad de Sevilla)
Tipo Año Título Fuente
Artículo2023 La fuerza y el lado oscuro de la inmunonutrición ACTA/CL: revista de la Asociación de Científicos y Tecnólogos de Alimentos de Castilla y León
Letter2023 MPXV and SARS-CoV-2 in the air of nightclubs in Spain The Lancet Microbe
Artículo2022 Characterisation of Zamorano-leonese donkey milk as an alternative sustainably produced protein food Frontiers in Nutrition
Artículo2022 Conjunctival intraepithelial lymphocytes, lacrimal cytokines and ocular commensal microbiota: analysis of the three main players in allergic conjunctivitis FRONTIERS IN IMMUNOLOGY
Resumen congreso2022 Nutritional benefits of donkey milk ANNALS OF NUTRITION AND METABOLISM
Artículo2022 Occupational hypersensitivity pneumonitis caused by fossil-containing rocks CLINICA CHIMICA ACTA
Artículo2021 Adverse Reactions to Illicit Drugs (Marijuana, Opioids, Cocaine) and Alcohol Journal of Allergy and Clinical Immunology: In Practice
Revisión2021 Covid-19 in the field of education: State of the art SUSTAINABILITY
Capítulo2021 Divulgación en redes sociales Metodología de la investigación: de lector a divulgador
Artículo2021 Eficacia del modelo de aula invertida (flipped classroom) en la enseñanza universitaria: una síntesis de las mejores evidencias REVISTA DE EDUCACION
Artículo2021 Epithelial component and intraepithelial lymphocytes of conjunctiva-associated lymphoid tissue in healthy children HISTOLOGY AND HISTOPATHOLOGY
Artículo2021 Evaluación en Educación Superior durante la pandemia de la COVID-19 CAMPUS VIRTUALES
Artículo2021 MSocial: Practical Integration of Social Learning Analytics Into Moodle IEEE ACCESS
Capítulo2021 Recommendations for mandatory online assessment in higher education during the COVID-19 pandemic Radical solutions for education in a crisis context: COVID-19 as an opportunity for global learning
Ponencia2020 Bootstrapping the Virtualization in a Face-to-Face University Proceedings - 10th International Conference on Virtual Campus, JICV 2020
Artículo2020 La CoVId-19: ¿enzima de la transformación digital de la docencia o reflejo de una crisis metodológica y competencial en la educación superior? CAMPUS VIRTUALES
Artículo2020 La evaluación online en la educación superior en tiempos de la COVID-19 Education in the knowledge society (EKS)
Artículo2020 Online Assessment in Higher Education in the Time of COVID-19 Education in the knowledge society (EKS)
Artículo2020 The COVID-19: the enzyme of the digital transformation of teaching or the reflection of a methodological and competence crisis in higher education? CAMPUS VIRTUALES
Artículo2020 The CoVId-19: The enzyme of the digital transformation of teaching or the reflection of a methodological and competence crisis in higher education? CAMPUS VIRTUALES
Artículo2019 Aula invertida en enseñanzas sanitarias: recomendaciones para su puesta en práctica FEM. Revista de la Fundación Educación Médica
Revisión2019 Component-resolved diagnosis in allergic disease: Utility and limitations CLINICA CHIMICA ACTA
Artículo2019 Molecular study of hypersensitivity to spores in adults and children from Castile & Leon ALLERGOLOGIA ET IMMUNOPATHOLOGIA
Artículo2018 Effects of competitive learning tools on medical students: A case study PLOS ONE
Libro2018 Inmunogenética Inmunogenética
Artículo2018 Nuevas combinaciones de aula inversa con just in time teaching y análisis de respuestas de los alumnos RIED-REVISTA IBEROAMERICANA DE EDUCACION A DISTANCIA
Ponencia2017 Innovación Trasmedia: incorporando al alumnado en la transformación docente X Jornadas de Innovación Docente 2017: Redes para la innovación: la participación del alumnado
Ponencia2017 La innovación educativa y la formación docente en la Universidad de Valladolid Xardes-Innovaestic 2017: Llibre d'actes
Ponencia2017 Valoración de los cursos de formación docente en la Universidad de Valladolid Xardes-Innovaestic 2017: Llibre d'actes
Resumen congreso2016 Immunomedia project: learning, lecturing and spreading Immunology European Journal Of Immunology
Resumen congreso2016 Increased gamma delta T cells and decreased NKT, Th and B1 cells in conjunctiva in elderly: lymphocyte subsets in peripheral blood and conjunctival IELs European Journal Of Immunology
Ponencia2016 Inmunomedia 4.0: enseñando, aprendiendo y divulgando Inmunología. Una experiencia interuniversitaria vertebrada en 4 ejes. VI jornada de innovación docente de la Universidad de Valladolid: Los universos docentes
Libro2016 VI jornada de innovación docente de la Universidad de Valladolid: Los universos docentes VI jornada de innovación docente de la Universidad de Valladolid: Los universos docentes
Artículo2015 In Vitro Model for Predicting the Protective Effect of Ultraviolet-Blocking Contact Lens in Human Corneal Epithelial Cells CURRENT EYE RESEARCH
Capítulo2015 Inmunomedia 3.0: selección, colección y creación, difusión y evaluación deMateriales Educativos Multimedia (MEM) de Inmunología entre Profesores yAlumnos. Proyecto de innovación docente de la Universidad de Valladolid (UVa) de los años 2013-2014 y 2014-2015
Capítulo2015 INMUNOMEDIA 4.0: Enseñando y aprendiendo Inmunología (proyecto en 4.0 ejes) Proyecto de innovación docente de la Universidad de Valladolid (UVa) de los años 2013-2014 y 2014-2015
Libro2015 Proyecto de innovación docente de la Universidad de Valladolid (UVa) de los años 2013-2014 y 2014-2015 Proyecto de innovación docente de la Universidad de Valladolid (UVa) de los años 2013-2014 y 2014-2015
Artículo2015 Value of microarray allergen assay in the management of eosinophilic oesophagitis ALLERGOLOGIA ET IMMUNOPATHOLOGIA
Resumen congreso2014 Conjunctival cell viability and apoptosis after one month of treatment with Thealoz (R) in dry eye subjects INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Capítulo2014 Una mirada hacia la excelencia docente desde las TICs La innovación educativa para transformar la sociedad multicultural: el papel de las universidades
Artículo2013 A new webpage for everyone Inmunología
Artículo2013 Fatal disseminated Scedosporium prolificans infection initiated by ophthalmic involvement in a patient with acute myeloblastic leukemia DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Artículo2013 Flow cytometry assessment of the purity of human retinal pigment epithelial primary cell cultures Journal of Immunological Methods
Artículo2013 In Vitro Simulation of Corneal Epithelium Microenvironment Induces a Corneal Epithelial-like Cell Phenotype from Human Adipose Tissue Mesenchymal Stem Cells CURRENT EYE RESEARCH
Resumen congreso2013 INTERLABORATORY COMPARISONS IN HISTOCOMPATIBILITY: GECLID-SEI HLA TYPING SCHEMES TISSUE ANTIGENS
Resumen congreso2013 VIRTUAL VS REAL CROSSMATCHES IN GECLID-SEI HLA INTERLABORATORY COMPARISON SCHEMES TISSUE ANTIGENS
Artículo2012 Topographical distribution and characterization of epithelial cells and intraepithelial lymphocytes in the human ocular mucosa MUCOSAL IMMUNOLOGY
Artículo2011 Differential Cell Proliferation, Apoptosis, and Immune Response in Healthy and Evaporative-Type Dry Eye Conjunctival Epithelia INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Revisión2011 GECLID: An initiative from Sociedad Española de Inmunología with returns for everyone Inmunología
Artículo2011 Trypan Blue staining method for quenching the autofluorescence of RPE cells for improving protein expression analysis EXPERIMENTAL EYE RESEARCH
Artículo2010 Dry Eye Disease as an Inflammatory Disorder Ocular Immunology and Inflammation
Resumen congreso2010 Flow Cytometric Analysis of Conjunctival Cells in Dry Eye Patients and Healthy Donors INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Libro2010 Inmunología: biología y patología del sistema inmunitario Inmunología: biología y patología del sistema inmunitario
Resumen congreso2010 Neuroretinal Reactive Gliosis is Not Appreciable If Macrophage-Like Cells Do Not Produce TNF Alpha and/or IL-1b. Preliminary Results INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Artículo2009 Characterization and short-term culture of cells recovered from human conjunctival epithelium by minimally invasive means MOLECULAR VISION
Artículo2009 Characterization and short-term culture of cells recovered from human conjunctival epithelium by minimally invasive means. MOLECULAR VISION
Ponencia2008 Uso de "moodle" en la asignatura "Inmunología General" de Medicina Innovación docente: docencia y TICs
Artículo2006 Inmunomodulación por yogur fresco versus yogur pasteurizado Alimentacion, Nutrición y Salud
Artículo2003 Mutations of CD40 ligand in two patients with hyper-IgM syndrome IMMUNOBIOLOGY
Artículo2002 Complete cDNA sequences of the HLA-DRB1*0402 and DRB1*11041 alleles EUROPEAN JOURNAL OF IMMUNOGENETICS
Artículo2002 Complete cDNA sequences of the HLA-DRB1*14011,*1402,*1403 and*1404 alleles TISSUE ANTIGENS
Artículo2002 Further polymorphism of the MICA gene EUROPEAN JOURNAL OF IMMUNOGENETICS
Artículo2001 A novel HLA-DRB1 sequence, DRB1*11272 TISSUE ANTIGENS
Artículo2001 A point mutation in a domain of gamma interferon receptor 1 provokes severe immunodeficiency CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
Artículo2001 A point mutation in a domain of IFN gamma receptor 1 provokes severe immunodeficiency EUROPEAN JOURNAL OF IMMUNOGENETICS
Artículo2001 Cathepsin C gene: First compound heterozygous patient with Papillon-Lefevre syndrome and a novel symptomless mutation HUMAN MUTATION
Artículo2001 Cathepsin C gene: First compound heterozygous patient with papillon-lefevre syndrome, a new symptomless mutation and its possible regulation by retinoids EUROPEAN JOURNAL OF IMMUNOGENETICS
Artículo2001 Cell surface phenotype and cytokine secretion in Caco-2 cell cultures: Lack of HLA class II molecules and increased RANTES production and IL-2 transcription upon stimulation with IL-1β EUROPEAN JOURNAL OF IMMUNOGENETICS
Artículo2001 New mutations and defective phorbol myristate acetate activation of T-lvmphocytes in ataxia telangiectasia patients EUROPEAN JOURNAL OF IMMUNOGENETICS
Artículo2001 Novel mutations and defective protein kinase C activation of T-lymphocytes in ataxia telangiectasia CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Artículo2001 Role of Nijmegen breakage syndrome protein in specific T-lymphocyte activation pathways CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
Artículo2000 A new MICA allele with ten alanine residues in the exon 5 microsatellite TISSUE ANTIGENS
Artículo2000 A novel CD18 genomic deletion in a patient with severe leucocyte adhesion deficiency: a possible CD2/lymphocyte function-associated antigen-1 functional association in humans IMMUNOLOGY
Ponencia2000 CD18 genomic deletion in a severe LAD patient IX MEETING OF THE EUROPEAN SOCIETY FOR IMMUNODEFICIENCIES
Ponencia2000 Immunodeficiency associated with anorexia nervosa is secondary and improves after refeeding IX MEETING OF THE EUROPEAN SOCIETY FOR IMMUNODEFICIENCIES
Corrección2000 Reference strand mediated conformation analysis resolves HLA-DRB1 typing ambiguities when matching for unrelated bone marrow (vol 56, pg 82, 2000) TISSUE ANTIGENS
Artículo2000 Reference strand mediated conformation analysis resolves HLB-DRB1 typing ambiguities when matching for unrelated bone marrow transplantation TISSUE ANTIGENS
Artículo1999 CD3 deficiencies Primary immunodeficiency diseases
Resumen congreso1999 Does the polymorphism of MICA influence bone marrow transplant complications? BLOOD
Artículo1999 Higher incidence of autoantibodies in X-linked chronic granulomatous disease carriers: Random X-chromosome inactivation may be related to autoimmunity AUTOIMMUNITY
Resumen congreso1999 RSCA (reference strand mediated conformation analysis) resolves HLA-DRB1*04 typing ambiguities where other molecular techniques fail. BLOOD
Resumen congreso1998 Immunodeficiency associated to anorexia nervosa is secondary and improves after refeeding. MOLECULAR IMMUNOLOGY
Artículo1998 Immunodeficiency associated with anorexia nervosa is secondary and improves after refeeding IMMUNOLOGY
Artículo1998 Immunodeficiency associated with anorexia nervosa is secondary and improves after refeeding IMMUNOLOGY
Ponencia1998 Mesa redonda. Inmunología para pediatras: inmunodeficiencias primarias. Técnicas diagnósticas XX Congreso Español Extraordinario de Pediatría: 10-13 de junio de 1998, Palacio de Congresos de Torremolinos (Málaga)
Resumen congreso1998 Molecular evolution of C4 complement gene primates MOLECULAR IMMUNOLOGY
Resumen congreso1998 Retinol (vitamin A) is a cofactor in CD3-induced human T lymphocyte activation: Its use in immunodeficiencies therapy MOLECULAR IMMUNOLOGY
Artículo1997 Cell surface phenotype and ultramicroscopic analysis of purified human enterocytes: a possible antigen presenting cell in the intestine TISSUE ANTIGENS
Artículo1997 Lupus like lesions in a patient with X-linked chronic granulomatous disease and recombinant X chromosome DERMATOLOGY
Artículo1997 Retinol (vitamin A) is a cofactor in CD3-induced human T-lymphocyte activation IMMUNOLOGY
Resumen congreso1996 C4 gene polymorphism in primates: Evolution, generation, and Chido and Rodgers antigenicity Human Immunology
Artículo1996 Diploid expression of human leukocyte antigen class I and class II molecules on spermatozoa and their cyclic inverse correlation with inhibin concentration BIOLOGY OF REPRODUCTION
Artículo1996 Frequencies of HLA-A24 and HLA-DR4-DQ8 are increased and that of HLA-B blank is decreased in chronic toxic oil syndrome EUROPEAN JOURNAL OF IMMUNOGENETICS
Artículo1996 Herpes virus saimiri transformation of T cells in CD3 gamma immunodeficiency: Phenotypic and functional characterization Journal of Immunological Methods
Resumen congreso1996 HLA-A24, HLA-DR4-DQ8 increase and HLA-B blank decrease in chronic Toxic Oil Syndrome Human Immunology
Resumen congreso1996 Immunodeficiency secondary to hepatitis C virus reduces acute rejection incidence and increases severe infections in renal transplant recipients. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Artículo1996 Molecular diagnosis of primary immunodeficiencies Inmunología
Resumen congreso1996 New HLA-G alleles and their linkage disequilibria with HLA-A Human Immunology
Artículo1996 Primate DRB6 gene expression and evolution: A study in Macaca mulatta and Cercopithecus aethiops TISSUE ANTIGENS
Revisión1995 DISEASES INVOLVING THE T-CELL RECEPTOR/CD3 COMPLEX CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Letter1995 IMMUNOSUPPRESSION INDUCED BY HEPATITIS-C VIRUS-INFECTION REDUCES ACUTE RENAL-TRANSPLANT REJECTION LANCET
Artículo1994 C4 gene polymorphism in primates: evolution, generation, and Chido and Rodgers antigenicity IMMUNOGENETICS
Artículo1994 NEW SPECIES-SPECIFIC ALLELES AT THE PRIMATE MHC-G LOCUS Human Immunology
Artículo1994 PERIPHERAL-BLOOD REDUCTION OF MEMORY (CD29(+), CD45RO(+), AND BRIGHT CD2(+) AND LFA-1(+)) T-LYMPHOCYTES IN PAPILLON-LEFEVRE SYNDROME Human Immunology
Artículo1994 Primary T lymphocyte immunodeficiency associated with a selective impairment of CD2, CD3, CD43 (but not CD28)-mediated signal transduction CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Artículo1994 PRIMARY T-LYMPHOCYTE IMMUNODEFICIENCY ASSOCIATED WITH A SELECTIVE IMPAIRMENT OF CD2, CD3, CD43 (BUT NOT CD28)-MEDIATED SIGNAL-TRANSDUCTION CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Artículo1993 3 NEW HLA-G ALLELES AND THEIR LINKAGE DISEQUILIBRIA WITH HLA-A IMMUNOGENETICS
Artículo1993 A study of DR2-LUM haplotype generation and the DRB6*0202 linkage to DRB1*1601 IMMUNOGENETICS
Artículo1993 DIFFERENTIAL CONTRIBUTION OF C4 AND HLA-DQ GENES TO SYSTEMIC LUPUS-ERYTHEMATOSUS SUSCEPTIBILITY HUMAN GENETICS
Resumen congreso1993 EVOLUTIONARY RELATIONSHIPS OF HLA-DR8 ALLELES AND DESCRIPTION OF A NEW SUBTYPE (DRB1-ASTERISK-0806) IN THE ALGERIAN POPULATION Human Immunology
Artículo1993 NEW DNA-SEQUENCES FOR THE HUMAN-COMPLEMENT GENE C4 MOLECULAR IMMUNOLOGY
Resumen congreso1993 NEW DNA-SEQUENCES FOR THE HUMAN-COMPLEMENT GENE-C4 Human Immunology
Artículo1993 Three new HLA-G alleles and their linkage disequilibria with HLA-A IMMUNOGENETICS
Corrección1992 Allelic diversity at the primate major histocompatibility complex DRB6 locus IMMUNOGENETICS
Artículo1992 Allelic diversity at the primate major histocompatibility complex DRB6 locus IMMUNOGENETICS
Artículo1992 COMPARISON BETWEEN HLA-DRB AND DQ DNA-SEQUENCES AND CLASSIC SEROLOGICAL MARKERS AS TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS PREDICTIVE RISK MARKERS IN THE SPANISH POPULATION DIABETOLOGIA
Editorial1992 FROM PATHOLOGY TO PHYSIOLOGY OF THE HUMAN LYMPHOCYTE-T RECEPTOR SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Artículo1992 From Pathology to Physiology of the Human T‐Lymphocyte Receptor SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Revisión1992 HUMAN T-CELL ACTIVATION DEFICIENCIES Immunology Today
Artículo1992 Lymphomatoid papulosis: a study of 18 cases JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
Nota1992 PRIMARY IMMUNODEFICIENCY CAUSED BY MUTATIONS IN THE GENE ENCODING THE CD3-GAMMA SUBUNIT OF THE LYMPHOCYTE-T RECEPTOR NEW ENGLAND JOURNAL OF MEDICINE
Nota1991 AUTOIMMUNOGENIC HLA-DRB1-STAR-0301 ALLELE (DR3) MAY BE DISTINGUISHED AT THE DRB1 NONCODING REGIONS OF HLA-B8,DR3,DW24 AND B18,DR3,DW25 HAPLOTYPES MOLECULAR IMMUNOLOGY
Artículo1991 C4 CHIDO-3 AND CHIDO-6 DISTINGUISH 2 DIABETOGENIC HAPLOTYPES - HLA-B49,SC01,DR4,DQW8 AND B8,SC01,DR3,DQW2 IMMUNOBIOLOGY
Artículo1991 EXCLUSIVE HLA-DQ FACTORS DO NOT EXPLAIN SUSCEPTIBILITY TO INSULIN-DEPENDENT DIABETES Human Immunology
Artículo1991 EXON-2 NUCLEOTIDE-SEQUENCES, POLYMORPHISM AND HAPLOTYPE DISTRIBUTION OF A NEW HLA-DRB GENE - HLA-DRB-SIGMA MOLECULAR IMMUNOLOGY
Artículo1991 HIGH-FREQUENCY OF THE HLA-DRB1-STAR-0405-(DW15)-DQW8 HAPLOTYPE IN SPANIARDS AND ITS RELATIONSHIP TO DIABETES SUSCEPTIBILITY Human Immunology
Artículo1991 THE HLA-DRB6 LOCUS DEFINES AN EVOLUTIONARY SUPRATYPIC GROUP WITHIN THE DRB FAMILY OF GENES INTERNATIONAL JOURNAL OF CANCER
Artículo1991 The HLA‐DRB6 locus defines an evolutionary supratypic group within the DRB family of genes INTERNATIONAL JOURNAL OF CANCER
Nota1990 2 NOVEL HLA-DRB TAQ I RFLPS DISTINGUISH HLA-BW57-DR7-DRB4-NULL FROM DRB4-POSITIVE HAPLOTYPES NUCLEIC ACIDS RESEARCH
Artículo1990 BOTH HLA CLASS-II AND CLASS-III DNA POLYMORPHISMS ARE LINKED TO JUVENILE RHEUMATOID-ARTHRITIS SUSCEPTIBILITY CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY
Nota1990 EXON-2 DNA-SEQUENCE OF THE HLA-DRW13B ALLELE OBTAINED FROM GENOMES OF 5 DIFFERENT INDIVIDUALS MOLECULAR IMMUNOLOGY
Artículo1990 SHARED SSTI RFLPS BY HLA-AW19, A23/24 AND A3/11 CROSS-REACTING GROUPS TISSUE ANTIGENS
Nota1989 A NEW HLA-DQA1 RFLP ALLELE [DQ-ALPHA-3B] DISTINGUISHES BETWEEN DQ-ALPHA GENES OF DQW2-DR3 AND DQW3-DR5 HAPLOTYPES NUCLEIC ACIDS RESEARCH
Nota1989 AN ECO RI POLYMORPHIC SITE IN THE HUMAN-COMPLEMENT C-4 GENE DISTINGUISHES JUVENILE RHEUMATOID-ARTHRITIS (JRA) SUSCEPTIBILITY-BEARING HAPLOTYPES MOLECULAR IMMUNOLOGY
Nota1989 DESCRIPTION OF AN HLA-DQA1 RFLP ALLELE [DQ-ALPHA-4] DEFINING DQW4/DRW8-BEARING HAPLOTYPES NUCLEIC ACIDS RESEARCH
Resumen congreso1988 STUDY OF HLA CLASS-II AND DNA RESTRICTION FRAGMENTS IN IDD AND NIDD CLINICAL GENETICS
Artículo1987 AN INVIVO FUNCTIONAL IMMUNE-SYSTEM LACKING POLYCLONAL T-CELL SURFACE EXPRESSION OF THE CD3/TI(WT31) COMPLEX SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Resumen congreso1987 FAMILIAL T-CELL RECEPTOR COMPLEX DEFICIENCY JOURNAL OF CELLULAR BIOCHEMISTRY

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/09/2023 31/08/2027 Investigador/a Papel de los ácidos grasos de la dieta en la comunicación intercelular mediada por vesículas extracelulares: una aproximación multiómica para una nutrición de precisión (PID2022-138650OA-I00) Ministerio de Ciencia e Innovación (Nacional)

Contratos

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
13/12/2023 31/10/2027 Responsable Papel de la IL-23 en la Enfermedad Inflamatoria Intestinal (5017/2045) 18 Razones Imprescindibles (Desconocido)
El investigador no tiene ningún resultado de investigación asociado