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Maria Luisa Castejon Martinez

Acceso Margarita Salas (USE)
mcastejon1@us.es
Área de conocimiento: Farmacología
Departamento: Farmacología
Grupo: FARMACOLOGÍA EXPERIMENTAL Y FARMACIA CLÍNICA - CTS-259 (Universidad de Sevilla)

Investiga en

Tipo Año Título Fuente
Artículo2024 Health-Promoting Properties of Pectin-Polyphenol Complex Extracted from Olive Oil By-Product Alperujo: Antioxidant, Antiproliferative, and Anti-Inflammatory Activities ANTIOXIDANTS
Artículo2024 Immunomodulatory Effects and Regulatory Mechanisms of (R)-6-HITC, an Isothiocyanate from Wasabi (Eutrema japonicum), in an Ex Vivo Mouse Model of LPS-Induced Inflammation JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2024 Isolation and structural determination of cis- and trans-p-coumaroyl-secologanoside (comselogoside) from olive oil waste (alperujo). Photoisomerization with ultraviolet irradiation and antioxidant activities FOOD CHEMISTRY
Artículo2023 An Acid-Free Alternative to Pectin Production from the Cell Walls of Olive Oil Waste and Different Fruits Using Choline Chloride FOODS
Revisión2023 Epigenetic linkage of systemic lupus erythematosus and nutrition NUTRITION RESEARCH REVIEWS
Artículo2023 Extraction of polyphenols associated with pectin from olive waste (alperujo) with choline chloride FOOD CHEMISTRY
Artículo2023 Oleocanthal Supplemented Diet Improves Renal Damage And Endothelial Dysfunction In Pristane-Induced Systemic Lupus Erythematosus In Mice FOOD RESEARCH INTERNATIONAL
Artículo2022 (−)-methyl-oleocanthal, a new oleocanthal metabolite reduces LPS-induced inflammatory and oxidative response: Molecular signaling pathways and histones epigenetic modulation ANTIOXIDANTS
Artículo2022 Ligstroside aglycon, an extra virgin olive oil secoiridoid, prevents inflammation by regulation of MAPKs, JAK/STAT, NF-κB, Nrf2/HO-1, and NLRP3 inflammasome signaling pathways in LPS-stimulated murine peritoneal macrophages FOOD & FUNCTION
Artículo2021 A new peracetylated oleuropein derivative ameliorates joint inflammation and destruction in a murine collagen-induced arthritis model via activation of the nrf-2/ho-1 antioxidant pathway and suppression of mapks and nf-κb activation NUTRIENTS
Artículo2021 Dietary oleocanthal supplementation prevents inflammation and oxidative stress in collagen-induced arthritis in mice. ANTIOXIDANTS
Artículo2020 Dietary oleuropein and its acyl derivative ameliorate inflammatory response in peritoneal macrophages from pristane-induced SLE mice via canonical and noncanonical NLRP3 inflammasomes pathway FOOD & FUNCTION
Artículo2020 Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function FOOD & FUNCTION
Revisión2020 Potential protective role exerted by secoiridoids from olea europaea l. In cancer, cardiovascular, neurodegenerative, aging-related, and immunoinflammatory diseases ANTIOXIDANTS
Artículo2019 Dietary oleuropein and its new acyl-derivate attenuate murine lupus nephritis through HO-1/Nrf2 activation and suppressing JAK/STAT, NF-κB, MAPK and NLRP3 inflammasome signaling pathways JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Resumen congreso2019 Oleocanthal modulates LPS-induced murine peritoneal macrophages activation via regulation of inflammasome and Nrf-2/HO-1 signaling pathways BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Artículo2019 Oleocanthal modulates LPS-induced murine peritoneal macrophages activation via regulation of inflammasome, Nrf-2/HO-1, and MAPKs signaling pathways JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2019 Olive secoiridoid oleuropein and its semisynthetic acetyl-derivatives reduce LPS-induced inflammatory response in murine peritoneal macrophages via JAK-STAT and MAPKs signaling pathways JOURNAL OF FUNCTIONAL FOODS
Artículo2019 Polyphenolic extract from extra virgin olive oil inhibits the inflammatory response in IL-1 beta-activated synovial fibroblasts BRITISH JOURNAL OF NUTRITION
Artículo2019 Preventive effect of bergenin against the development of TNBS-induced acute colitis in rats is associated with inflammatory mediators inhibition and NLRP3/ASC inflammasome signaling pathways CHEMICO-BIOLOGICAL INTERACTIONS
Artículo2019 Quercus ilex extract ameliorates acute TNBS-induced colitis in rats PLANTA MEDICA
Resumen congreso2018 Inhibitory effects of oleuropein and its peracetylated derivative on human osteoclastogenesis BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Resumen congreso2018 Oleuropein and its new acylated derivatives reduce lps-induced inflammatory response in murine peritoneal macrophages BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Artículo2018 Peracetylated hydroxytyrosol, a new hydroxytyrosol derivate, attenuates LPS-induced inflammatory response in murine peritoneal macrophages via regulation of non-canonical inflammasome, Nrf2/HO1 and JAK/STAT signaling pathways JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Artículo2017 Extra-virgin olive oil phenols hydroxytyrosol and hydroxytyrosol acetate, down-regulate the production of mediators involved in joint erosion in human synovial cells JOURNAL OF FUNCTIONAL FOODS
Artículo2017 Oleuropein down-regulated IL-1 beta-induced inflammation and oxidative stress in human synovial fibroblast cell line SW982 FOOD & FUNCTION
Corrección2017 Oleuropein down-regulated IL-1 beta-induced inflammation and oxidative stress in human synovial fibroblast cell line SW982 (vol 8, pg 1890, 2017) FOOD & FUNCTION
Resumen congreso2017 Oleuropein exhibited anti-inflammatory and anti-oxidant activities in il-1 beta-stimulated human synovial fibroblasts BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Revisión2016 Extra virgin olive oil: a key functional food for prevention of immune-inflammatory diseases FOOD & FUNCTION
Resumen congreso2015 Protective effect of a quercus ilex l. mature leaves extract in a murine model of crohn's disease BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
02/12/2022 31/12/2025 Investigador/a Funcionalidad del aceite de oliva virgen extra en la prevención de la artritis psoriásica: implicaciones epigenéticas (PROYEXCEL_00547) Junta de Andalucía (Consejería de Transformación Económica, Industria, Conocimiento y Universidades) (Autonómico)
01/12/2022 30/06/2025 Investigador/a Compuestos fenólicos de la hoja del olivo como nueva herramienta terapéutica para la espondiloartritis axial (TED2021-130708B-I00) Ministerio de Ciencia e Innovación (Nacional)
01/01/2018 30/06/2021 Investigador/a Secoiridoides del olivo como nuevos nutracéuticos moduladores epigenéticos de la respuesta inmunoinflamatoria (AGL2017-89342-P) Ministerio de Economía y Competitividad (Nacional)
01/09/2022 31/08/2025 Investigador/a Secoiridoides del olivo en la terapia nutricional del lupus eritematoso sistémico: implicaciones epigenéticas (PID2021-125488OB-I00) Ministerio de Ciencia e Innovación (Nacional)
01/01/2015 31/12/2018 Contratado Desarrollo de formulaciones innovadoras con nanopartículas mucoadhesivas para el tratamiento de úlceras mucosales (NANOMUC) (RTC-2015-4437-1) Ministerio de Economía y Competitividad (Nacional)
01/01/2012 30/09/2015 Contratado Estudio Químico Biodirigido y Caracterización Farmacológica del Aceite de Oliva Virgen Extra en el Lupus Eritematoso Sistémico Experimental. (AGL2011-26949) Ministerio de Ciencia e Innovación (Nacional)

Contratos

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
30/10/2020 30/11/2020 Investigador/a Ensayo de validación del proceso de AM3 mediante la inhibición de la producción de factor de necrosis tumoral (TNF) inducida por endotoxina bacteriana (LPS) en modelo de macrófagos peritoneales murinos (3952/0990) Industrial Farmacéutica Cantabria, S.A. (Desconocido)
El investigador no tiene ningún resultado de investigación asociado